Naseer Ahmad Chaudhry

Chemotherapeutic/chemopreventive role of retinoids in chemically induced skin carcinogenesis in albino mice

Objective  To determine the chemotherapeutic effect of retinoids on albino mouse skin.

Elevated frequency of p53 genetic mutations and AgNOR values in squamous cell carcinoma

Background:  Epidermal squamous cell carcinoma (SCC) is a common malignancy in Pakistan. We hypothesize that it is characterized by higher frequency of p53 genetic mutations and increased AgNOR values compared with squamous cell papilloma (SCP) and basal cell carcinoma (BCC).

Relationship of immunohistochemistry scores of altered p53 protein expression in relation to patient's habits and histological grades and stages of squamous cell carcinoma.

Background:  p53 mutations are etiologically associated with the development of squamous cell carcinomas (SCCs) or with exposure to specific carcinogens. The study was conducted to examine the relationship of immunohistochemistry (IHC) scores between altered p53 protein expression in relation to patient’s habits and histological grades and stages of SCC.

A comparative study of FDPs and D-dimers in patients with breast cancer

Seventy Five subjects were selected. Fifty subjects were breast cancer patients and 25 healthy control subjects were included. FDPs and D-dimers were performed by using commercially available kits. Results obtained were analyzed by using chi-square (X2) test and level of significance was done. A significant increase in the levels of FDPs and D-dimers were found in patients with breast cancer.