Nasser Mohammed Hosny

Synthesis, spectral characterization and DNA binding of Schiff-base metal complexes derived from 2-amino-3-hydroxyprobanoic acid and acetylacetone

Four new metal complexes derived from the reaction of Cu(II), Co(II), Ni(II) and Zn(II) acetates with the Schiff-base ligand (H3L) resulted from the condensation of the amino acid 2-amino-3-hydroxyprobanoic acid (serine) and acetylacetone have been synthesized and characterized by, elemental analyses, ES-MS, IR, UV-Vis., 1H NMR, 13C NMR, ESR, thermal analyses (TGA and DTG) and magnetic measurements. The results showed that the Schiff-base ligand acts as bi-negative tridentate through the azomethine nitrogen, the deprotonated carboxylate oxygen and the enolic carbonyl oxygen. The optical band gaps measurements indicated the semi-conducting nature of these complexes. Molecular docking was used to predict the binding between the Schiff base ligand with the receptor of prostate cancer mutant H874Y. The interactions between the Cu(II) complex and calf thymus DNA (CT-DNA) have been studied by UV spectra. The results confirm that the Cu(II) complex binds to CT-DNA in an intercalative mode.

Synthesis, spectral, optical and anti-inflammatory activity of complexes derived from 2-aminobenzohydrazide with some rare earths

Abstract Three new metal complexes derived from Er(III), Dy(III) and Zr(IV) with 2-aminobenzohydrazide (ABH) were synthesized and characterized by elemental analyses, IR, 1H-NMR, ES-MS and transmission electron microscopy (TEM). The morphology and the particle size were determined by TEM. The results showed that the ligand acted as neutral bi-dentate coordinating to the metal ions through the carbonyl oxygen and amidic amino nitrogen. The aromatic amine group remained inert towards coordination. The optical band gap was measured and found to be 3.3, 3.5 and 4.3 eV for Er(III), Dy(III) and Zr(IV), respectively. The optical band gap values indicated a semi-conducting nature of the investigated complexes. The anti-inflammatory and analgesic activities of the tested compounds were determined and compared with standard meloxicam.

Poly(o-toluidine dihydrochloride): Spectral Characterization and Synthesis of Eskolite Nanoparticles

ABSTRACT Poly(o-toluidine · 2HCl) and its doped polymers with Mn and Cr ions have been synthesized and characterized by FT-IR, UV–Vis. and thermogravimetrical analyses. Potassium dichromate has been used as an initiator and a dopant of chromium in CrPOT preparation. The effect of doping on thermal and optical properties of Poly(o-toluidine dihydrochloride) has been discussed. CrPOT has been used as a precursor of Cr2O3 nanoparticles through thermal decomposition rout. The obtained nanoparticles have been characterized by X-ray diffraction and high resolution transmission electron microscope. The results indicated that Cr2O3 exists in hexagonal structure as mesoporous Eskolit with average particle size of 48 nm. Optical band gap measurements indicated that Eskolite nanoparticles have wider band gap than the bulk. GRAPHICAL ABSTRACT

Synthesis and Characterization of Transition Metal Complexes Derived from (E)-N-(1-(Pyridine-2-yl)ethylidiene)benzohydrazide (PEBH)

Three metal complexes derived from (E)-N-(1-(pyridine-2-yl)ethylidene)benzohydrazide (PEBH) with Cu(II), Co(II), and Ni(II) have been synthesized and characterized using elemental analyses, spectral analyses (infrared [IR], ultraviolet [UV], mass spectroscopy [MS], nuclear magnetic resonance [1H-NMR]), thermal analyses, conductance, and magnetic measurements. The results showed that 1:1 (M:L) chelates with the general formula [M L Ac]nH2O have been formed. IR and 1H-NMR spectra of the ligand (E)-N-(1-(pyridine-2-yl)ethylidene)benzohydrazide (PEBH) showed that the free ligand exists in the keto form, while it binds to the metal ions in the enol form. The difference between νas and νs stretching vibrations of the acetate group suggests the monodentate nature of this group. Some semiempirical calculations of the vibrational spectra have been done using AM1, PM3, and ZINDO/1 methods to assist in the assignments of the experimental results. The optical band gap (Eg) values of Co, Ni, and Cu were found to be 3.4, 1.45, and 1.20 eV, respectively, arising from direct transitions. These values indicate the semiconductivity nature of these complexes.

Doped poly(m-phenylenediamine) (PmPDA): A new precursor for Cr2O3 nanoparticles

Poly(m-phenylene diamine) has been synthesized and characterized by physical and spectral techniques. The effect of doping Cr, Co and Ni ions on the spectral, thermal and optical properties has been studied. Optical band gap measurements indicated that, doped polymers have wider optical band gap than the pure one. The effect of doping on the thermal stability differs according to the doped metal ion. The doped with Cr ions poly(m-phenylenediamine) has been used as a precursor of mesoporous Cr2O3 nanoparticles, which have been also characterized by XRD and HR-TEM.

Anti-inflammatory activity of (2E,15E)-2-[1-(2-aminophenyl)ethylidineamino]-N′-[1-(2-aminophenyl)ethylidene]benzoic acid hydrazide (AEBH) and some of its nanoparticles rare earth complexes

Complexes of Er(III), Gd(III), and La(III) with (2E,15E)-2-[1-(2-aminophenyl)ethylidineamino]-N′-[1-(2-aminophenyl)ethylidene]benzoic acid hydrazide (AEBH) have been synthesized. The isolated complexes were characterized by elemental analyses, thermal analyses (TGA, DTA), IR, 1H NMR, 13C NMR, ES-MS, TEM, and conductance measurements. The results indicated that the ligand coordinates to La(III), Gd(III), and Er(III) in the keto form as neutral pentadentate ligand. The particle size and morphology have been determined by TEM. In vivo pharmacological evaluation of the synthesized compounds in collagen II—Freund’s adjuvant model proved the presence of anti-inflammatory and analgesic activities of these compounds. Gd(III) complex showed higher effect in comparison with the well-known drug meloxicam.Graphical Abstract

Synthesis, characterization, and anti-rheumatic potential of phthalazine-1,4-dione and its Cu(II) and Zn(II) complexes

Abstract Two new metal complexes derived from the reaction of 2-[(2-hydroxybenzoyl) 2,3,4a,5,10,10a-hexahydro-5,10[1′,2′]-benzenobenzo[g]phthalazine-1,4-dione] (HBPD) with Cu(II) and Zn(II) have been synthesized and characterized by using elemental analysis, spectral analysis (UV–Vis, IR, 1H NMR, 13C NMR), conductance, thermal analysis, and magnetic moments. The in vivo collagen-adjuvant arthritis model in rats revealed a significant antioxidant, analgesic, and anti-rheumatic effects for HBPD and its copper and zinc complexes in comparison with standard piroxicam. The results showed that, the investigated Cu and Zn complexes have higher anti-inflammatory activity than the free ligand.

Synthesis and Spectral Characterization of Some Complexes Derived From N-Benzoyl-N′-Carboxylmethylthiopropylidine Thiourea (Bcmt)

Abstract New metal complexes derived from the reaction of N-benzoyl-N′-carboxyl methylthiopropylidine thiourea (BCMT) with Cu(II), Co(II), Ni(II), and Fe(III) chloride and/or acetate salts have been synthesized and characterized using elemental analyses, molar conductance, spectral (IR, UV-Vis., mass, 1H NMR), thermal (TGA, DTG), and magnetic measurements. The IR results showed the modes of coordination in case of mononuclear and binuclear metal complexes. Different types of geometries are suggested on the basis of the spectral and the magnetic data. Also, the ligand field parameters for the metal complexes were calculated. The amounts of the solvents as well as the mechanism of decomposition were proposed using thermal measurements. The results of biological activity of the ligand give us the promise to be effective in tumors treatment. GRAPHICAL ABSTRACT

2-Hydroxybenzaldehyde-(4,6-Dimethylquinolin-2-yl)-Hydrazone (HBDH), Synthesis, Characterization, and Ligational Behavior Towards Some Metals

2-Hydroxybenzaldehyde-(4,6-dimethylquinolin-2-yl)-hydra-zone, and its metal complexes with Cu(II), Co(II), Ni(II), and Zn(II) have been synthesized and characterized using elemental analyses, spectral analyses (IR, UV, 1 H-NMR, MS), thermal analyses (TGA and DTG), conductance and magnetic measurements. The results showed that 2-hydroxybenzaldehyde-(4,6-dimethylquinolin-2-yl)-hydrazone acts as mononegative tridentate ligand coordinating to the metal ions through quinoline nitrogen, azomethine nitrogen and phenolic oxygen after deprotonation. The difference between ν as and ν as stretching vibrations indicates that acetate group binds to the metal ions in a bi-dentate fashion. An octahedral stereochemistry has been suggested for all metal ions. The vibrational spectra of the ligand and its metal complexes have been calculated using semi-empirical calculations, AM1, PM3 and ZINDO/1 methods, to facilitate the assignments of the experimental spectra. Also, the optical band gap (Eg) of the metal complexes has been calculated. The optical transition energy (Eg) is direct and equals 2.40, 2.62 and 2.71 ev for Co, Ni and Cu complexes, respectively.

Doped Poly(m-phenylenediamine-co-aniline) (P(mPD-co-ANI)): Synthesis, Characterization, Physical Properties, and Precursor for CuO Nanoparticles

ABSTRACT Poly(m-phenylenediamine-co-aniline) P(mPD-co-ANI) and Mn-, Ni-, and Cu-doped poly(m-phenylenediamine-co-aniline) (M-P(mPD-co-ANI)) have been synthesized and characterized. Cu-P(mPD-co-ANI) has been used as a molecular precursor of CuO nanoparticles. The spectral, optical, refractive index, solubility, and thermal properties of the synthesized polymers have been measured and discussed. The optical bandgap (Eg) measurements indicated that Ni(P(mPD-co-ANI)) has wider optical band than the pure (P(mPD-co-ANI)). Calcination of Cu-P(mPD-co-ANI) at 600°C produced (CuO) nanoparticles. The obtained nanoparticles have been characterized by XRD and TEM. The average size of CuO nanoparticles was found to be 42 nm. The refractive index measurements indicate slight change in the refractive index values of the polymer solution than that of pure solvent. The solubility of the synthesized polymers in ethanol, dimethyl formamide (DMF)–aqueous mixed solvents was found to increase as the mole fractions of both ethanol and DMF increase. The UV spectra of the synthesized polymers in ethanol, DMF–aqueous mixed solvents indicate blueshift and hyperchromic effect. GRAPHICAL ABSTRACT