Natalia Andrushko
Leibniz Association
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Featured researches published by Natalia Andrushko.
Chemcatchem | 2010
Natalia Andrushko; Vasyl Andrushko; Peter Roose; Kristof Moonen; Armin Börner
Catalytic transformation of alcohols to amines is a fundamental transformation in synthetic organic chemistry. Since a variety of amines play an important role as precursors and final products employed in pharmaceuticals such as anticancer agents and DNA alkylators, agrochemicals, flavors and fragrances, cosmetics and toiletries, polymers, dyes, and other fine chemicals, the development of versatile and efficient amination methods is still an area of vital research. In recent years, a number of transition metal-catalyzed reactions for the synthesis of aliphatic and aromatic amines, such as hydroamination of alkenes or alkynes 4] and aryl halides, has been developed. Moreover, N-alkylation with alkyl halides is a well-known procedure, but the use of alkyl halides is undesirable from an environmental point of view, since it generates wasteful salts as byproducts. Another useful approach in the synthesis of amines is the reductive amination of aldehydes and ketones. However, this method requires the use of strong reducing reagents or dangerous hydrogen gas and is not always selective for monoalkylation of primary amines. Catalytic amination of alcohols is an alternative method for the preparation of amines (Scheme 1) and it is attractive from
Chirality | 2010
Natalia Andrushko; Vasyl Andrushko; Vitali Tararov; Andrei Korostylev; Gerd König; Armin Börner
Statins are inhibitors of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMG-CoA reductase) and became the standard of care for treatment of hypercholesterolemia because of their efficacy, safety, and long-term benefits. They are administered as diastereo- and enantiomerically pure compounds. We summarize here two new approaches for the total synthesis of the most important representatives, atorvastatin, and rosuvastatin, based on highly stereoselective hydrogenations as key-steps.
Journal of Physical Chemistry A | 2008
Vladimir N. Emel'yanenko; Alexey V. Toktonov; Svetlana A. Kozlova; Sergey P. Verevkin; Vasyl Andrushko; Natalia Andrushko; Armin Börner
Standard molar enthalpies of formation in the gaseous state of a series of alkyl 3-methylbut-2-enoates have been obtained from combustion calorimetry and results from the temperature dependence of the vapor pressure measured by the transpiration method. To verify the experimental data, we have performed ab initio calculations of all compounds. Enthalpies of formation derived from the G3MP2 method are in excellent agreement with the experimental results. Quantitative analysis of strain effects in alkyl 3-methylbut-2-enoates was discussed in terms of deviations of deltafH degrees m(g) from the group additivity rules. Energetics of the cis-trans isomerization of carboxylic acid derivatives was studied using G3MP2 and DFT methods. Values of strain and cis-trans corrections derived in this work provide further improvement on the group-contribution methodology for prediction of the thermodynamic properties of compounds relevant to biodiesel.
Archive | 2013
Vasyl Andrushko; Natalia Andrushko
European Journal of Organic Chemistry | 2008
Natalia Andrushko; Vasyl Andrushko; Gerd König; Anke Spannenberg; Armin Börner
European Journal of Organic Chemistry | 2006
Vitali Tararov; Natalia Andrushko; Vasyl Andrushko; Gerd König; Anke Spannenberg; Armin Börner
European Journal of Organic Chemistry | 2008
Andrei Korostylev; Vasyl Andrushko; Natalia Andrushko; Vitali Tararov; Gerd König; Armin Börner
Tetrahedron Letters | 2008
Natalia Andrushko; Vasyl Andrushko; Thomas Thyrann; Gerd König; Armin Börner
Tetrahedron Letters | 2008
Vasyl Andrushko; Natalia Andrushko; Gerd König; Armin Börner
ChemInform | 2009
Vasyl Andrushko; Natalia Andrushko; Armin Boerner