Natalia Santanielo Silva

Ação do licopeno nos músculos esquelético e cardíaco sob estresse oxidativo por exercícios

Introduction: Free radicals produced during exercise may exceed the antioxidant defense system, causing oxidative damage to specific biomolecules. The lesions caused by free radicals in cells can be prevented or reduced by natural antioxidants, which are found in many foods. Lycopene is one of the most potent carotenoids with antioxidant properties, and it is used to prevent carcinogenesis and atherogenesis, as it protects molecules such as lipids, low-density lipoproteins (LDL), proteins and DNA. Objective: To investigate the role of lycopene as a potential protector of cardiac and skeletal muscle fibers against oxidative stress during strenuous exercise, which would cause morphological changes in these tissues. Methods: The experiments consisted of 32 adult male rats divided into four groups: two control groups and two trained groups with and without lycopene supplementation (6 mg per animal). The animals of the trained groups were subjected to 42 swimming sessions over a nine-week period, involving daily swimming sessions, five days a week, with overload produced by increasing the training time. The morphological analysis was performed using histological slides of cardiac and skeletal muscle tissues. Results: Modifications were observed in cardiac and skeletal muscle tissue in the trained group that did not receive lycopene supplementation, while the trained group supplemented with lycopene showed muscle tissue with a normal morphological appearance. The tissues of both supplemented and non supplemented sedentary control groups showed no change in their histological characteristics. Conclusion: It can be stated that lycopene exerted a protective effect on cardiac and skeletal muscles against oxidative stress induced by strenuous exercise, besides promoting cardiac neovascularization, and can be used efficiently by athletes and physically active individuals.^aINTRODUCAO: Os radicais livres produzidos durante os exercicios podem exceder o sistema de defesa antioxidante, provocando danos oxidativos de biomoleculas especificas. As lesoes causadas pelos radicais livres nas celulas podem ser prevenidas ou reduzidas por meio da atividade de antioxidantes naturais, sendo estes encontrados em muitos alimentos. O licopeno e um dos mais potentes carotenoides com acao antioxidante, sendo utilizado na prevencao da carcinogenese e aterogenese por proteger moleculas como lipidios, lipoproteinas de baixa densidade (LDL), proteinas e DNA.OBJETIVO: Investigar a atuacao do licopeno a uma possivel acao protetora das fibras musculares cardiacas e esqueleticas contra o estresse oxidativo, durante a atividade fisica exaustiva, a qual provocaria alteracoes morfologicas nesses tecidos. Metodo: Na realizacao dos experimentos foram utilizados 32 ratos machos adultos divididos em quatro grupos, sendo dois grupos controles e dois grupos treinados sem e com suplementacao de licopeno (6 mg por animal). Os animais dos grupos treinados foram submetidos a 42 sessoes de natacao por nove semanas, com sessoes diarias de natacao, cinco dias por semana, com sobrecarga produzida pelo aumento do tempo de treinamento. A avaliacao morfologica foi realizada por meio de lâminas histologicas dos tecidos cardiaco e muscular esqueletico.RESULTADOS: Modificacoes teciduais cardiacas e musculares esqueleticas no grupo treinado sem suplementacao com licopeno foram observadas, sendo que o grupo treinado suplementado apresentou aspecto morfologico normal. Nos grupos sedentarios controle suplementado e nao suplementado nao houve alteracao em relacao as caracteristicas histologicas dos tecidos.CONCLUSAO: Podemos afirmar que o licopeno exerceu um efeito protetor nos musculos cardiaco e esqueletico contra o estresse oxidativo, induzido por exercicios exaustivos, alem de promover uma neovascularizacao do tecido cardiaco, podendo ser utilizado com eficiencia por atletas e praticantes de atividade fisica.^lpt^aINTRODUCTION: Free radicals produced during exercise may exceed the antioxidant defense system, causing oxidative damage to specific biomolecules. The lesions caused by free radicals in cells can be prevented or reduced by natural antioxidants, which are found in many foods. Lycopene is one of the most potent carotenoids with antioxidant properties, and it is used to prevent carcinogenesis and atherogenesis, as it protects molecules such as lipids, low-density lipoproteins (LDL), proteins and DNA.OBJECTIVE: To investigate the role of lycopene as a potential protector of cardiac and skeletal muscle fibers against oxidative stress during strenuous exercise, which would cause morphological changes in these tissues.METHODS: The experiments consisted of 32 adult male rats divided into four groups: two control groups and two trained groups with and without lycopene supplementation (6 mg per animal). The animals of the trained groups were subjected to 42 swimming sessions over a nine-week period, involving daily swimming sessions, five days a week, with overload produced by increasing the training time. The morphological analysis was performed using histological slides of cardiac and skeletal muscle tissues.RESULTS: Modifications were observed in cardiac and skeletal muscle tissue in the trained group that did not receive lycopene supplementation, while the trained group supplemented with lycopene showed muscle tissue with a normal morphological appearance. The tissues of both supplemented and non supplemented sedentary control groups showed no change in their histological characteristics.CONCLUSION: It can be stated that lycopene exerted a protective effect on cardiac and skeletal muscles against oxidative stress induced by strenuous exercise, besides promoting cardiac neovascularization, and can be used efficiently by athletes and physically active individuals.^len^aINTRODUCCION: Los radicales libres producidos durante los ejercicios pueden exceder el sistema de defensa antioxidante, provocando danos oxidativos de biomoleculas especificas. Las lesiones causadas por los radicales libres en las celulas pueden ser prevenidas o reducidas por medio de la actividad de antioxidantes naturales, siendo estos encontrados en muchos alimentos. El licopeno es uno de los mas potentes carotenoides con accion antioxidante, siendo utilizado en la prevencion de la carcinogenesis y aterogenesis por proteger moleculas como lipidos, lipoproteinas de baja densidad (LDL), proteinas y DNA.OBJETIVO: Investigar la actuacion del licopeno a una posible accion protectora de las fibras musculares cardiacas y esqueleticas contra el estres oxidativo, durante la actividad fisica exhaustiva, la cual provocaria alteraciones morfologicas en esos tejidos.METODOS: En la realizacion de los experimentos fueron utilizados 32 ratones machos adultos divididos en cuatro grupos, siendo dos grupos controles y dos grupos entrenados sin y con suplementacion de licopeno (6 mg por animal). Los animales de los grupos entrenados fueron sometidos a 42 sesiones de natacion por nueve semanas, con sesiones diarias de natacion, cinco dias por semana, con sobrecarga producida por el aumento del tiempo de entrenamiento. La evaluacion morfologica fue realizada por medio de laminas histologicas de los tejidos cardiaco y muscular esqueletico.RESULTADOS: Fueron observadas modificaciones tisulares cardiacas y musculares esqueleticas en el grupo entrenado sin suplementacion con licopeno, siendo que el grupo entrenado suplementado presento aspecto morfologico normal. En los grupos sedentarios control suplementado y no suplementado no hubo alteracion en relacion a las caracteristicas histologicas de los tejidos.CONCLUSION: Podemos afirmar que el licopeno ejercio un efecto protector en los musculos cardiaco y esqueletico contra el estres oxidativo, inducido por ejercicios exhaustivos, ademas de promover una neovascularizacion del tejido cardiaco, pudiendo ser utilizado con eficiencia por atletas y practicantes de actividad fisica.^les

Acción del licopeno en los músculos cardiaco y esquelético bajo estrés oxidativo por ejercicios

Introduction: Free radicals produced during exercise may exceed the antioxidant defense system, causing oxidative damage to specific biomolecules. The lesions caused by free radicals in cells can be prevented or reduced by natural antioxidants, which are found in many foods. Lycopene is one of the most potent carotenoids with antioxidant properties, and it is used to prevent carcinogenesis and atherogenesis, as it protects molecules such as lipids, low-density lipoproteins (LDL), proteins and DNA. Objective: To investigate the role of lycopene as a potential protector of cardiac and skeletal muscle fibers against oxidative stress during strenuous exercise, which would cause morphological changes in these tissues. Methods: The experiments consisted of 32 adult male rats divided into four groups: two control groups and two trained groups with and without lycopene supplementation (6 mg per animal). The animals of the trained groups were subjected to 42 swimming sessions over a nine-week period, involving daily swimming sessions, five days a week, with overload produced by increasing the training time. The morphological analysis was performed using histological slides of cardiac and skeletal muscle tissues. Results: Modifications were observed in cardiac and skeletal muscle tissue in the trained group that did not receive lycopene supplementation, while the trained group supplemented with lycopene showed muscle tissue with a normal morphological appearance. The tissues of both supplemented and non supplemented sedentary control groups showed no change in their histological characteristics. Conclusion: It can be stated that lycopene exerted a protective effect on cardiac and skeletal muscles against oxidative stress induced by strenuous exercise, besides promoting cardiac neovascularization, and can be used efficiently by athletes and physically active individuals.^aINTRODUCAO: Os radicais livres produzidos durante os exercicios podem exceder o sistema de defesa antioxidante, provocando danos oxidativos de biomoleculas especificas. As lesoes causadas pelos radicais livres nas celulas podem ser prevenidas ou reduzidas por meio da atividade de antioxidantes naturais, sendo estes encontrados em muitos alimentos. O licopeno e um dos mais potentes carotenoides com acao antioxidante, sendo utilizado na prevencao da carcinogenese e aterogenese por proteger moleculas como lipidios, lipoproteinas de baixa densidade (LDL), proteinas e DNA.OBJETIVO: Investigar a atuacao do licopeno a uma possivel acao protetora das fibras musculares cardiacas e esqueleticas contra o estresse oxidativo, durante a atividade fisica exaustiva, a qual provocaria alteracoes morfologicas nesses tecidos. Metodo: Na realizacao dos experimentos foram utilizados 32 ratos machos adultos divididos em quatro grupos, sendo dois grupos controles e dois grupos treinados sem e com suplementacao de licopeno (6 mg por animal). Os animais dos grupos treinados foram submetidos a 42 sessoes de natacao por nove semanas, com sessoes diarias de natacao, cinco dias por semana, com sobrecarga produzida pelo aumento do tempo de treinamento. A avaliacao morfologica foi realizada por meio de lâminas histologicas dos tecidos cardiaco e muscular esqueletico.RESULTADOS: Modificacoes teciduais cardiacas e musculares esqueleticas no grupo treinado sem suplementacao com licopeno foram observadas, sendo que o grupo treinado suplementado apresentou aspecto morfologico normal. Nos grupos sedentarios controle suplementado e nao suplementado nao houve alteracao em relacao as caracteristicas histologicas dos tecidos.CONCLUSAO: Podemos afirmar que o licopeno exerceu um efeito protetor nos musculos cardiaco e esqueletico contra o estresse oxidativo, induzido por exercicios exaustivos, alem de promover uma neovascularizacao do tecido cardiaco, podendo ser utilizado com eficiencia por atletas e praticantes de atividade fisica.^lpt^aINTRODUCTION: Free radicals produced during exercise may exceed the antioxidant defense system, causing oxidative damage to specific biomolecules. The lesions caused by free radicals in cells can be prevented or reduced by natural antioxidants, which are found in many foods. Lycopene is one of the most potent carotenoids with antioxidant properties, and it is used to prevent carcinogenesis and atherogenesis, as it protects molecules such as lipids, low-density lipoproteins (LDL), proteins and DNA.OBJECTIVE: To investigate the role of lycopene as a potential protector of cardiac and skeletal muscle fibers against oxidative stress during strenuous exercise, which would cause morphological changes in these tissues.METHODS: The experiments consisted of 32 adult male rats divided into four groups: two control groups and two trained groups with and without lycopene supplementation (6 mg per animal). The animals of the trained groups were subjected to 42 swimming sessions over a nine-week period, involving daily swimming sessions, five days a week, with overload produced by increasing the training time. The morphological analysis was performed using histological slides of cardiac and skeletal muscle tissues.RESULTS: Modifications were observed in cardiac and skeletal muscle tissue in the trained group that did not receive lycopene supplementation, while the trained group supplemented with lycopene showed muscle tissue with a normal morphological appearance. The tissues of both supplemented and non supplemented sedentary control groups showed no change in their histological characteristics.CONCLUSION: It can be stated that lycopene exerted a protective effect on cardiac and skeletal muscles against oxidative stress induced by strenuous exercise, besides promoting cardiac neovascularization, and can be used efficiently by athletes and physically active individuals.^len^aINTRODUCCION: Los radicales libres producidos durante los ejercicios pueden exceder el sistema de defensa antioxidante, provocando danos oxidativos de biomoleculas especificas. Las lesiones causadas por los radicales libres en las celulas pueden ser prevenidas o reducidas por medio de la actividad de antioxidantes naturales, siendo estos encontrados en muchos alimentos. El licopeno es uno de los mas potentes carotenoides con accion antioxidante, siendo utilizado en la prevencion de la carcinogenesis y aterogenesis por proteger moleculas como lipidos, lipoproteinas de baja densidad (LDL), proteinas y DNA.OBJETIVO: Investigar la actuacion del licopeno a una posible accion protectora de las fibras musculares cardiacas y esqueleticas contra el estres oxidativo, durante la actividad fisica exhaustiva, la cual provocaria alteraciones morfologicas en esos tejidos.METODOS: En la realizacion de los experimentos fueron utilizados 32 ratones machos adultos divididos en cuatro grupos, siendo dos grupos controles y dos grupos entrenados sin y con suplementacion de licopeno (6 mg por animal). Los animales de los grupos entrenados fueron sometidos a 42 sesiones de natacion por nueve semanas, con sesiones diarias de natacion, cinco dias por semana, con sobrecarga producida por el aumento del tiempo de entrenamiento. La evaluacion morfologica fue realizada por medio de laminas histologicas de los tejidos cardiaco y muscular esqueletico.RESULTADOS: Fueron observadas modificaciones tisulares cardiacas y musculares esqueleticas en el grupo entrenado sin suplementacion con licopeno, siendo que el grupo entrenado suplementado presento aspecto morfologico normal. En los grupos sedentarios control suplementado y no suplementado no hubo alteracion en relacion a las caracteristicas histologicas de los tejidos.CONCLUSION: Podemos afirmar que el licopeno ejercio un efecto protector en los musculos cardiaco y esqueletico contra el estres oxidativo, inducido por ejercicios exhaustivos, ademas de promover una neovascularizacion del tejido cardiaco, pudiendo ser utilizado con eficiencia por atletas y practicantes de actividad fisica.^les

Action of lycopene on the cardiac and skeletal muscles under oxidative stress by exercises

Introduction: Free radicals produced during exercise may exceed the antioxidant defense system, causing oxidative damage to specific biomolecules. The lesions caused by free radicals in cells can be prevented or reduced by natural antioxidants, which are found in many foods. Lycopene is one of the most potent carotenoids with antioxidant properties, and it is used to prevent carcinogenesis and atherogenesis, as it protects molecules such as lipids, low-density lipoproteins (LDL), proteins and DNA. Objective: To investigate the role of lycopene as a potential protector of cardiac and skeletal muscle fibers against oxidative stress during strenuous exercise, which would cause morphological changes in these tissues. Methods: The experiments consisted of 32 adult male rats divided into four groups: two control groups and two trained groups with and without lycopene supplementation (6 mg per animal). The animals of the trained groups were subjected to 42 swimming sessions over a nine-week period, involving daily swimming sessions, five days a week, with overload produced by increasing the training time. The morphological analysis was performed using histological slides of cardiac and skeletal muscle tissues. Results: Modifications were observed in cardiac and skeletal muscle tissue in the trained group that did not receive lycopene supplementation, while the trained group supplemented with lycopene showed muscle tissue with a normal morphological appearance. The tissues of both supplemented and non supplemented sedentary control groups showed no change in their histological characteristics. Conclusion: It can be stated that lycopene exerted a protective effect on cardiac and skeletal muscles against oxidative stress induced by strenuous exercise, besides promoting cardiac neovascularization, and can be used efficiently by athletes and physically active individuals.^aINTRODUCAO: Os radicais livres produzidos durante os exercicios podem exceder o sistema de defesa antioxidante, provocando danos oxidativos de biomoleculas especificas. As lesoes causadas pelos radicais livres nas celulas podem ser prevenidas ou reduzidas por meio da atividade de antioxidantes naturais, sendo estes encontrados em muitos alimentos. O licopeno e um dos mais potentes carotenoides com acao antioxidante, sendo utilizado na prevencao da carcinogenese e aterogenese por proteger moleculas como lipidios, lipoproteinas de baixa densidade (LDL), proteinas e DNA.OBJETIVO: Investigar a atuacao do licopeno a uma possivel acao protetora das fibras musculares cardiacas e esqueleticas contra o estresse oxidativo, durante a atividade fisica exaustiva, a qual provocaria alteracoes morfologicas nesses tecidos. Metodo: Na realizacao dos experimentos foram utilizados 32 ratos machos adultos divididos em quatro grupos, sendo dois grupos controles e dois grupos treinados sem e com suplementacao de licopeno (6 mg por animal). Os animais dos grupos treinados foram submetidos a 42 sessoes de natacao por nove semanas, com sessoes diarias de natacao, cinco dias por semana, com sobrecarga produzida pelo aumento do tempo de treinamento. A avaliacao morfologica foi realizada por meio de lâminas histologicas dos tecidos cardiaco e muscular esqueletico.RESULTADOS: Modificacoes teciduais cardiacas e musculares esqueleticas no grupo treinado sem suplementacao com licopeno foram observadas, sendo que o grupo treinado suplementado apresentou aspecto morfologico normal. Nos grupos sedentarios controle suplementado e nao suplementado nao houve alteracao em relacao as caracteristicas histologicas dos tecidos.CONCLUSAO: Podemos afirmar que o licopeno exerceu um efeito protetor nos musculos cardiaco e esqueletico contra o estresse oxidativo, induzido por exercicios exaustivos, alem de promover uma neovascularizacao do tecido cardiaco, podendo ser utilizado com eficiencia por atletas e praticantes de atividade fisica.^lpt^aINTRODUCTION: Free radicals produced during exercise may exceed the antioxidant defense system, causing oxidative damage to specific biomolecules. The lesions caused by free radicals in cells can be prevented or reduced by natural antioxidants, which are found in many foods. Lycopene is one of the most potent carotenoids with antioxidant properties, and it is used to prevent carcinogenesis and atherogenesis, as it protects molecules such as lipids, low-density lipoproteins (LDL), proteins and DNA.OBJECTIVE: To investigate the role of lycopene as a potential protector of cardiac and skeletal muscle fibers against oxidative stress during strenuous exercise, which would cause morphological changes in these tissues.METHODS: The experiments consisted of 32 adult male rats divided into four groups: two control groups and two trained groups with and without lycopene supplementation (6 mg per animal). The animals of the trained groups were subjected to 42 swimming sessions over a nine-week period, involving daily swimming sessions, five days a week, with overload produced by increasing the training time. The morphological analysis was performed using histological slides of cardiac and skeletal muscle tissues.RESULTS: Modifications were observed in cardiac and skeletal muscle tissue in the trained group that did not receive lycopene supplementation, while the trained group supplemented with lycopene showed muscle tissue with a normal morphological appearance. The tissues of both supplemented and non supplemented sedentary control groups showed no change in their histological characteristics.CONCLUSION: It can be stated that lycopene exerted a protective effect on cardiac and skeletal muscles against oxidative stress induced by strenuous exercise, besides promoting cardiac neovascularization, and can be used efficiently by athletes and physically active individuals.^len^aINTRODUCCION: Los radicales libres producidos durante los ejercicios pueden exceder el sistema de defensa antioxidante, provocando danos oxidativos de biomoleculas especificas. Las lesiones causadas por los radicales libres en las celulas pueden ser prevenidas o reducidas por medio de la actividad de antioxidantes naturales, siendo estos encontrados en muchos alimentos. El licopeno es uno de los mas potentes carotenoides con accion antioxidante, siendo utilizado en la prevencion de la carcinogenesis y aterogenesis por proteger moleculas como lipidos, lipoproteinas de baja densidad (LDL), proteinas y DNA.OBJETIVO: Investigar la actuacion del licopeno a una posible accion protectora de las fibras musculares cardiacas y esqueleticas contra el estres oxidativo, durante la actividad fisica exhaustiva, la cual provocaria alteraciones morfologicas en esos tejidos.METODOS: En la realizacion de los experimentos fueron utilizados 32 ratones machos adultos divididos en cuatro grupos, siendo dos grupos controles y dos grupos entrenados sin y con suplementacion de licopeno (6 mg por animal). Los animales de los grupos entrenados fueron sometidos a 42 sesiones de natacion por nueve semanas, con sesiones diarias de natacion, cinco dias por semana, con sobrecarga producida por el aumento del tiempo de entrenamiento. La evaluacion morfologica fue realizada por medio de laminas histologicas de los tejidos cardiaco y muscular esqueletico.RESULTADOS: Fueron observadas modificaciones tisulares cardiacas y musculares esqueleticas en el grupo entrenado sin suplementacion con licopeno, siendo que el grupo entrenado suplementado presento aspecto morfologico normal. En los grupos sedentarios control suplementado y no suplementado no hubo alteracion en relacion a las caracteristicas histologicas de los tejidos.CONCLUSION: Podemos afirmar que el licopeno ejercio un efecto protector en los musculos cardiaco y esqueletico contra el estres oxidativo, inducido por ejercicios exhaustivos, ademas de promover una neovascularizacion del tejido cardiaco, pudiendo ser utilizado con eficiencia por atletas y practicantes de actividad fisica.^les