Natasha Singh

Unusual visceral distribution of technetium-99m-methylene diphosphonate in a case of hypercalcemia of malignancy

We report a case of 18-year-old boy who presented with vomiting, backache, and fever for 1-month, diagnosed to have anaplastic large cell lymphoma of urinary bladder with hypercalcemia and metastatic calcification in multiple viscera. His computed tomography scan was suggestive of soft tissue lesion in the urinary bladder and multiple lytic skeletal lesions. Bone scan showed unusual visceral uptake in lungs, liver, spleen, and myocardium in addition to osseous lesions. The clinical laboratory test revealed functional impairment of visceral organs. The patient died 3 months later.

Unusual asymptomatic fluorodeoxyglucose avid pheochromocytoma in a case of myxoid liposarcoma of the extremity on 18-F fluorodeoxyglucose positron emission tomography-computed tomography

Sarcomas are a heterogeneous group of rare tumors and arise either from soft tissue or from bone. Soft-tissue sarcomas (STSs) initially metastasize to the lungs. Metastases to extrapulmonary sites such as liver, brain, and soft tissue distant from primary tumor usually develop later. However, cases with isolated adrenal metastasis without disseminated disease have been reported in literature. We present a case of primary myxoid liposarcoma of the lower limb, in which staging 18-F fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) scan detected a suspicious FDG avid adrenal lesion which eventually on resection was diagnosed as asymptomatic pheochromocytoma. Pheochromocytomas have been reported to demonstrate FDG uptake mimicking metastasis. Hence, while interpreting FDG PET-CT scans in the context of STSs, both the extrapulmonary metastatic potential of aggressive histological subtypes of sarcoma and rare possibility of FDG avid coexistent benign tumor should be taken into consideration.

Epithelioid angiosarcoma: 10 years postrenal transplant

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18F-fludeoxyglucose positron emission tomography computed tomography-guided diagnosis of prostatic and leptomeningeal tuberculosis

Genitourinary tuberculosis contributes to 10%–14% of extrapulmonary TB. Prostate tuberculosis is rare and usually found incidentally following transurethral resection of the prostate for benign prostatic hyperplasia. We report a case of an immunocompetent patient with pyrexia of unknown origin, on evaluation with whole-body 18F-fludeoxyglucose positron emission tomography computed tomography scan found to have suspicious prostatic primary, with hypermetabolic abnormalities involving the brain. Histopathological diagnosis was established as multifocal tuberculosis involving prostate, meninges, and intracranial tuberculomas.

IgG4-Related disease simulating paraneoplastic syndrome: Role of 18FDG PET/CT imaging

Immunoglobulin G4 (IgG4)-related systemic disease (IgG4-RSD) is a new systemic entity associated with autoimmune pancreatitis (AIP). Other organ involvements take the form of sclerosing cholangitis, sclerosing cholecystitis, sclerosing sialadenitis, retroperitoneal fibrosis, and interstitial nephritis. Recently, lung diseases related to IgG4 have been described to occur with or without other organ involvement. These diseases include interstitial lung disease (ILD), pulmonary inflammatory pseudotumor, and lymphomatoid granulomatosis. Most of these cases occur in combination with AIP, which also appears to have a general preponderance for males. The true incidence of IgG4-related ILD and the incidence of AIP are unknown. Here, we describe a case of a 53-year-old gentleman who presented with weight loss, fever, loose motions, altered sensorium, and persistent low hemoglobin, for which he was referred for 18-fluorodeoxyglucose positron emission tomography/computed tomography scan to diagnose probable underlying occult malignancy/paraneoplastic syndrome. It revealed features suggestive of IgG4 disease involving the pancreas and lungs, which was confirmed subsequently.

Extranodal natural killer/T cell lymphoma with cardiac and abdominopelvic nodular deposits: Unique presentation on 18-fluorodeoxyglucose positron emission tomography computed tomography scan

Cardiac lymphoma as secondary extension of non-Hodgkins lymphoma is described in 30% of autopsies; however, a few cases are diagnosed in vivo. Primary lymphoma of the heart and pericardium is rare, accounting for 1.3% of primary cardiac tumors and only 0.5% of extranodal lymphomas at autopsy. We present a unique case of 68-year-old man diagnosed with extranodal lymphoma with cardiac and abdominopelvic nodular deposits on 18-fluorodeoxyglucose positron emission tomography-computed tomography scan findings.

Intramedullary osteosclerosis of right femur confirmed on triphasic bone SPECT/CT in a patient with equivocal radiological features.

Sclerotic bone dysplasias are diagnosed based on clinical and radiological features; however, in some instances pose a dilemma. We herewith report a case of a 38-year-old female who presented with right lower extremity pain, and was detected to have sclerotic diaphyseal lesion on X-ray. Triphasic 99mTc methylene diphosphonate (MDP) Bone scan helped in confirming the diagnosis of intramedullary osteosclerosis, a dysplastic bone disorder.

Unusual case of infantile fibrosarcoma evaluated on F-18 fluorodeoxyglucose positron emission tomography-computed tomography.

Infantile fibrosarcoma (IFS) is a rare soft-tissue sarcoma originating from extremities and occasionally from axial soft tissue. The prognosis is good with favorable long-term survival. It is rarely metastasizing tumor, the chances being lesser with IFS originating from extremities. Use of neoadjuvant chemotherapy (NACT) as a treatment regime further reduces the chances of local relapse and distant metastasis. The organs commonly affected in metastatic IFS are lungs and lymph nodes. We report an unusual case of an IFS originating from extremity, which received NACT, yet presented with an early metastatic disease involving soft tissues and sparing lungs and lymph nodes, as demonstrated on fluorodeoxyglucose positron emission tomography-computed tomography.

Incidental finding of sternal cleft on technetium-99m-methylene diphosphonate bone scan appearing as a necklace

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