Nathan K. Risk

Comparison between self-report and hair analysis of illicit drug use in a community sample of middle-aged men

Discrepancies between biological assays and self-report of illicit drug use could undermine epidemiological research findings. Two objectives of the present study are to examine the degree of agreement between self-reported illicit drug use and hair analysis in a community sample of middle-aged men, and to identify factors that may predict discrepancies between self-report and hair testing. Male participants followed since 1972 were interviewed about substance use, and hair samples were analyzed for marijuana, cocaine, opiates, phencyclidine (PCP) and methamphetamine using radioimmunoassay and gas chromatography-mass spectrometry (GC-MS) techniques. Self-report and hair testing generally met good, but not excellent, agreement. Apparent underreporting of recent cocaine use was associated with inpatient hospitalization for the participants most recent quit attempt, younger age, identifying as African American or other, and not having a diagnosis of antisocial personality disorder. The overestimate of marijuana use relative to hair test was associated with frequent use since 1972 and providing an inadequate hair sample. Additional research is needed to identify factors that differentially affect the validity of both hair drug testing and self-report.

Remission From Drug Abuse Over a 25-Year Period: Patterns of Remission and Treatment Use

OBJECTIVES Using an epidemiologically obtained sample, we examined patterns of illicit drug use, abuse, and remission over a 25-year period and recent treatment use. METHODS The surviving members of the cohort (n = 841), previously surveyed in 1972 and 1974, comprised 3 subsamples of Vietnam War enlisted men and civilian controls. Retrospectively obtained year-to-year measures from the 1996-1997 survey included use and remission of sedatives, stimulants, marijuana, cocaine, and opiates, as well as substance abuse and psychiatric treatment use. RESULTS Relatively stable patterns of frequent use in adulthood were found, with the mean duration from initiation to the last remission ranging from 9 to 14 years. A majority attempted to quit; however, most did not use traditional drug treatment in their last attempts. Fewer than 9% of the then-current drug users were treated in inpatient or outpatient settings at the time of data collection. CONCLUSIONS Most drug abusers who had started using drugs by their early 20s appeared to gradually achieve remission. Spontaneous remission was the rule rather than the exception. Nonetheless, considerable unmet needs existed for those who had continued use into middle age.

Twenty-five year mortality of US servicemen deployed in Vietnam: predictive utility of early drug use.

Large numbers of young men were exposed to high-quality opiates for a relatively short time period during military service in Vietnam. This study examined the relationships of opiate and other drug abuse before, during, and shortly after their time of service in Vietnam with the subsequent 25-year mortality among the cohort of 1227 US Army enlisted returnees and their matched civilians previously studied in 1972 and 1974. Composite factor scores of a variety of drug use measures and other individual behavioral measures were selected separately for three time periods around service in Vietnam from over 120 measures associated with mortality. Results of path analytic models applied to selected significant measures showed that both in-Vietnam and post-Vietnam drug use factors were large and significant predictors of mortality, controlling for pre-service drug use, continuity to later drug use, and demographic and other behavioral measures. The magnitude of the direct effect of drug use on mortality was larger than those of the covariates that were entered in the path analyses, except age. Notwithstanding the high remission rate from opiate addiction, drug use in Vietnam had considerable predictive utility for premature death in this cohort. In light of the re-emergence of increased heroin use since the mid-1990s, the findings point to the importance of early intervention of drug use and comorbid problems for todays youth now initiating heroin use.

Conduct disorder among Asians and Native Hawaiian/Pacific Islanders in the USA.

BACKGROUND Conduct disorder (CD) is a relatively common disorder of childhood and adolescence in the USA with substantial associated morbidity, yet little has been published on CD among Asians and Native Hawaiian/Pacific Islanders (NH/PI) in the USA. METHOD We used the National Epidemiological Survey on Alcohol and Related Conditions (NESARC) to examine the prevalence and correlates of retrospectively reported CD within Asians and NH/PI (18 years and older). We also completed logistic regressions to explore factors associated with CD within Asians (n=1093) and, separately, NH/PI (n=139) and to explain racial differences in CD prevalence. RESULTS Asians were about a third as likely [odds ratio (OR) 0.4, 95% confidence interval (CI) 0.22-0.58] whereas NH/PI were about two and half times more likely (OR 2.6, 95% CI 1.31-5.06) to have had CD compared with Caucasian respondents. Within Asians and NH/PI, CD was strongly associated with adult antisocial behavior, substance use and affective disorders. Demographic factors, the age that subjects came to the USA, measures of family environment and family history could not explain the observed differences in prevalence of CD for NH/PI relative to Caucasians. CONCLUSIONS Asian and NH/PI youth with CD represent a subgroup of Asian youth at very high risk for a number of serious psychiatric disorders. Further investigation is needed to explain the high CD prevalence among NH/PI.

Access, Quality and Satisfaction with Care: Concerns of Vietnam Veterans

The objectives of the current interim report are to measure the extent of the access to care problem, identify and compare the types of patient- and system-based barriers experienced by Vietnam veterans at risk for suicide when seeking care for physical, psychiatric, and substance abuse conditions, analyze patient-perceived quality of care for individuals who obtained access to care, and identify how the care-seeking experience effected future care seeking. This study is based on a longitudinal sample of 494 Vietnam veterans discharged from military service in September 1971 and subsequently identified as at risk for suicide (306 low risk; 188 high risk). Seventy-one percent (350) of 494 participants completed an extensive qualitative and quantitative interview covering, among other topics, physical conditions, psychiatric conditions, substance use, barriers to care, facilitators of care, and quality of care. Barriers, satisfaction, and effect of the experience were compared by type of condition and suicidal risk category using χ2 analysis and Fishers as appropriate. The analysis is based on 257 interviews (73 percent) with qualitative data transcribed thus far. Results: Of the 195 patients with self-reported health conditions, 76 (39.0 percent) and 45 (23.1 percent) expressed system-based barriers to care, respectively. The group at higher risk of suicide was significantly more likely (p<0.01) to report patient-based barriers to care and system-based barriers to care (p<0.05), and more likely (p<0.05) to experience negative effects of the care-seeking experience. Both self-perceived and system-based barriers to care pose obstacles for patients at high risk of suicide. Targeted interventions are required to reach out to these patients to address needs for care currently unmet by the health care system and to reduce negative effects of the health care experience.

Impact of behavioral health problems on access to care and health services utilization

Access to specialists for treatment of behavioral health problems has become restricted in this era of capped budgets and reductions in Medicare and Medicaid reimbursement. Patients with multiple mental health problems may face additional barriers to obtaining needed health care services. The studys aim was to measure the impact of behavioral health problems on access to care and health services utilization for veterans and non-veterans and to determine the contribution of health system characteristics in the prediction of self-reported health services utilization. The study sample consisted of Vietnam veterans who participated in both the Vietnam Drug User Study (September 1971 Army discharges) and the Vietnam Era Study (25-year follow-up) (N=642), as well as a non-veteran cohort (N=197).