Nathan T. Kuipers
Penn State Milton S. Hershey Medical Center
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Featured researches published by Nathan T. Kuipers.
American Journal of Physiology-heart and Circulatory Physiology | 2008
Sean C. Newcomer; Charity L. Sauder; Nathan T. Kuipers; M. H. Laughlin; Chester A. Ray
Shear rate is significantly lower in the superficial femoral compared with the brachial artery in the supine posture. The relative shear rates in these arteries of subjects in the upright posture (seated and/or standing) are unknown. The purpose of this investigation was to test the hypothesis that upright posture (seated and/or standing) would produce greater shear rates in the superficial femoral compared with the brachial artery. To test this hypothesis, Doppler ultrasound was used to measure mean blood velocity (MBV) and diameter in the brachial and superficial femoral arteries of 21 healthy subjects after being in the supine, seated, and standing postures for 10 min. MBV was significantly higher in the brachial compared with the superficial femoral artery during upright postures. Superficial femoral artery diameter was significantly larger than brachial artery diameter. However, posture had no significant effect on either brachial or superficial femoral artery diameter. The calculated shear rate was significantly greater in the brachial (73 +/- 5, 91 +/- 11, and 97 +/- 13 s(-1)) compared with the superficial femoral (53 +/- 4, 39 +/- 77, and 44 +/- 5 s(-1)) artery in the supine, seated, and standing postures, respectively. Contrary to our hypothesis, our current findings indicate that mean shear rate is lower in the superficial femoral compared with the brachial artery in the supine, seated, and standing postures. These findings of lower shear rates in the superficial femoral artery may be one mechanism for the higher propensity for atherosclerosis in the arteries of the leg than of the arm.
Journal of Applied Physiology | 2008
Nathan T. Kuipers; Charity L. Sauder; Jason R. Carter; Chester A. Ray
The purpose of this study was to determine neurovascular responses to mental stress (MS) in the supine and upright postures. MS was elicited in 23 subjects (26 +/- 1 yr) by 5 min of mental arithmetic. In study 1 (n = 9), Doppler ultrasound was used to measure mean blood flow velocity in the renal (RBFV) and superior mesenteric arteries (SMBFV), and venous occlusion plethysmography was used to measure forearm blood flow (FBF). In study 2 (n = 14), leg blood flow (LBF; n = 9) was measured by Doppler ultrasound, and muscle sympathetic nerve activity (MSNA; n = 5) was measured by microneurography. At rest, upright posture increased heart rate and MSNA and decreased LBF, FBF, RBFV, and SMBFV and their respective conductances. MS elicited similar increases in mean arterial blood pressure ( approximately 12 mmHg) and heart rate ( approximately 17 beats/min), regardless of posture. MS in both postures elicited a decrease in RBFV, SMBFV, and their conductances and an increase in LBF, FBF, and their conductances. Changes in blood flow were blunted in the upright posture in all vascular beds examined, but the pattern of the vascular response was the same as the supine posture. MS did not change MSNA in either posture (change: approximately 1 +/- 3 and approximately 3 +/- 3 bursts/min, respectively). In conclusion, the augmented sympathetic activity of the upright posture does not alter heart rate, mean arterial blood pressure, or MSNA responses to MS. MS elicits divergent vascular responses in the visceral and peripheral vasculature. These results indicate that, although the upright posture attenuates vascular responses to MS, the pattern of neurovascular responses does not differ between postures.
The Journal of Physiology | 2003
Nathan T. Kuipers; Charity L. Sauder; Chester A. Ray
Activation of the vestibular system changes ventilation in humans. The purpose of the present study was to investigate whether aging alters the vestibulorespiratory reflex in humans. Because aging attenuates the vestibulosympathetic reflex, it was hypothesized that aging would attenuate the vestibulorespiratory reflex. Changes in ventilation during engagement of the semicircular canals and/or the otolith organs were measured in fourteen young (26 ± 1 years) and twelve older subjects (66 ± 1 years). In young subjects, natural engagement of the semicircular canals and the otolith organs by head rotation increased breathing frequency during dynamic upright pitch at 0.25 Hz (15 cycles min−1) and 0.5 Hz (30 cycles min−1) (Δ2 ± 1 and Δ4 ± 1 breaths min−1, respectively; P < 0.05) and during dynamic upright roll (Δ2 ± 1 and Δ4 ± 1, respectively; P < 0.05). In older subjects, the only significant changes in breathing frequency occurred during dynamic pitch and roll at 0.5 Hz (Δ2 ± 1 and Δ2 ± 1 for pitch and roll, respectively). Stimulation of the horizontal semicircular canals by yaw rotation increased minute ventilation in young but not older subjects. Selective engagement of the otolith organs during static head‐down rotation did not alter breathing frequency in either the young or older subjects. The results of this study indicate that the vestibulorespiratory reflex is attenuated in older humans, with greater vestibular stimulation needed to activate the reflex.
American Journal of Physiology-renal Physiology | 2009
Nathan T. Kuipers; Charity L. Sauder; Matthew L. Kearney; Chester A. Ray
The purpose of the study was to determine the interactive effect of aging and forearm muscle heating on renal vascular conductance and muscle sympathetic nerve activity (MSNA) during ischemic isometric handgrip. A tube-lined, water-perfused sleeve was used to heat the forearm in 12 young (27 +/- 1 yr) and 9 older (63 +/- 1 yr) subjects. Ischemic isometric handgrip was performed before and after heating. Muscle temperature (intramuscular thermistor) was 34.3 +/- 0.2 and 38.7 +/- 0.1 degrees C during normothermia and heating, respectively. At rest, heating had no effect on renal blood velocity (Doppler ultrasound) or renal vascular conductance in either group (young, n = 12; older, n = 8). Heating compared with normothermia caused a significantly greater increase in renal vasoconstriction during exercise and postexercise muscle ischemia (PEMI) in both groups. However, the increase in renal vasoconstriction during heating was greater in the older compared with the young subjects (18 +/- 3 vs. 8 +/- 3%). During handgrip, heating elicited greater increases in MSNA responses in the older group (young, n = 12; older, n = 6), whereas no statistical difference was observed between groups during PEMI. In summary, aging augments renal vascular responses to ischemic isometric handgrip during heating of the exercising muscle. The greater renal vasoconstriction was associated with augmented MSNA in the older subjects.
Journal of Applied Physiology | 2007
Thad E. Wilson; Charity L. Sauder; Matthew L. Kearney; Nathan T. Kuipers; Urs A. Leuenberger; Kevin D. Monahan; Chester A. Ray
Journal of Applied Physiology | 2007
Nathan T. Kuipers; Charity L. Sauder; Chester A. Ray
Journal of Applied Physiology | 2004
Thad E. Wilson; Nathan T. Kuipers; Erica A. McHugh; Chester A. Ray
American Journal of Physiology-heart and Circulatory Physiology | 2007
Nathan T. Kuipers; Charity L. Sauder; Matthew L. Kearney; Chester A. Ray
Archive | 2015
Shawn G. Hayes; Marc P. Kaufman; Nathan T. Kuipers; Charity L. Sauder; Matthew L. Kearney; Chester A. Ray; Patrick J. Mueller; Megan N. Murphy; Masaki Mizuno; Jere H. Mitchell; Scott A. Smith; Richard Koerber; Michael P. Jankowski; Kristofer K. Rau; Katrina M. Ekmann; Collene E. Anderson
Archive | 2015
Lawrence I. Sinoway; Vahe E. Amassian; Jian Cui; Mithra Sathishkumar; Thad E. Wilson; Manabu Shibasaki; Scott L. Davis; G Craig; Nathan T. Kuipers; Charity L. Sauder; Chester A. Ray; Hirotsugu Tsuchimochi; Shawn G. Hayes; Jennifer L. McCord; Marc P. Kaufman; David J. Levinthal; Peter L. Strick
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United States Army Research Institute of Environmental Medicine
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