Naveen Acharya

Tamsulosin Facilitates Earlier Clearance of Stone Fragments and Reduces Pain After Shockwave Lithotripsy for Renal Calculi : Results From an Open-Label Randomized Study

OBJECTIVES To evaluate the role of tamsulosin in the clearance of fragments after extracorporeal shock wave lithotripsy (ESWL) to treat renal calculi. METHODS In this open-label prospective randomized study conducted at our institute from 2006 to 2007, 139 patients with normal renal function and a single radiopaque renal calculus, 5-20 mm, undergoing ESWL were enrolled. All patients underwent ESWL every 3 weeks until success or for <or=3 months, whichever was earlier. They were randomly assigned to 2 groups with respect to whether they had received tamsulosin, 0.4 mg/d. The primary endpoint was the success rate, and the secondary endpoints were clearance time, sessions required for clearance, pain intensity, incidence of steinstrasse, and the need for auxiliary procedures. RESULTS Of the 139 patients, 51 in group 1 and 65 in group 2 completed the requisite follow-up. The demographic profile of both groups was comparable. The success rate after 1, 2, and 3 ESWL sessions was greater in group 1 than in group 2 (52.9%, 78.4%, and 94.1% vs 30.8%, 52.3%, and 75.4%; P = .016, P = .004, and P = .007, respectively). The total days required for success (35.53 +/- 19.47 vs 47.22 +/- 23.64; P = .006), total ESWL sessions required for success (1.66 vs 2.16; P = .005), and the pain experienced (visual analog scale score 28.67 +/- 20.35 vs 47.30 +/- 24.98, respectively; P = .0001) were significantly less in group 1. Two patients in group 1 and 9 in group 2 developed steinstrasse (P = .10); conservative management was successful in 1 patient in each group (P = .345). Three patients in group 1 and 10 in group 2 required auxiliary procedures (P = .14). CONCLUSIONS The results of our study have shown that tamsulosin facilitates earlier clearance of fragments after ESWL to renal calculi and helps reduce the severity of the pain. It tended to facilitate spontaneous clearance of steinstrasse; however, this requires additional evaluation.

Heterogenous spectrum of CFTR gene mutations in Indian patients with congenital absence of vas deferens

BACKGROUND Mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene can cause congenital bilateral absence of vas deferens. Yet, the spectrum and frequency of CFTR mutations in Indian males with congenital absence of vas deferens (CAVD) is unknown. METHODS We investigated 50 Indian males, diagnosed with unilateral or bilateral absence of vas deferens at the PGIMER, Chandigarh, for the presence of the most common CFTR gene mutations as well as unknown mutations by single-strand conformation polymorphism followed by sequence analysis. RESULTS This study led to the identification of 12 CFTR gene mutations on 48% of 100 Indian CAVD chromosomes. CFTR mutations were identified on both alleles in 11 patients (22%) and on one allele in 26 patients (52%). Novel CFTR mutations identified were L69H, F87I, G126S, F157C, E543A, Y852F and D1270E. The T5 allele (25%) and F508del (11%) were the most common mutations identified. The most common intragenic marker haplotype for F508del was 2111 (GATT, TUB9, M470V and T854T). No mutations could be detected in 13 CAVD patients (26%), including 4 with renal malformations. CONCLUSIONS This study confirms the molecular heterogeneity of CFTR mutations in CAVD. Although the mutation detection rate is indeed lower in Indian CAVD patients, 74% of the patients tested had at least one CFTR mutation. CAVD alleles with no mutations suggest that other changes may be located at the non-screened sites that require extensive search by direct sequencing. Furthermore, the novel CFTR mutations identified require functional studies in a cell-based system.

Congenital vesicovaginal fistula with transverse vaginal septum and ectopic ureter opening in proximal vagina: case report and brief review

Congenital vesicovaginal fistula is an extreme rarity. We report on a case of a 22-year-old lady who presented with menouria and infertility. On evaluation, she was found to have congenital vesicovaginal fistula, a nonfunctioning right kidney with ectopic ureter and transverse vaginal septum. Abdominal repair of the fistula, right nephroureterectomy, and excision of the vaginal septum was performed.

Lactose intolerance in prostate cancer patients: Incidence and associated factors

Objective. Osteoporosis is common in prostate cancer (CaP) patients both before and after institution of androgen deprivation therapy and is associated with significant morbidity. Lactose intolerance (LI) can affect bone mass but has not been studied in this group of patients. The objective of this study was to compare the incidence of LI in CaP patients with that in the general population and to identify factors affecting lactose intolerance in CaP patients. Material and methods. Fifty-five men with CaP planned for bilateral orchidectomy were enrolled in the study and their baseline characteristics including age, weight, height, body mass index (BMI), prostate-specific antigen, serum calcium profile, lactose tolerance status, physical activity, alcohol intake and smoking, bone mineral density and calcium intake were registered. The data on lactose tolerance in these patients were compared with those of 81 age-matched controls (data taken from the available database). Results. The incidence of LI in CaP patients was significantly less than that in the control group (36.2% and 58.3%, respectively, p=0.027). A significantly greater number of CaP patients in the lactose-tolerant group had a calcium intake of >1500 mg/day (p=0.03) and that of milk >500 ml/day (p=0.05) than those in the intolerant group. Age >70 years, BMI <25 kg/m2, height >163 cm, lower physical activity and co-abuse of alcohol and smoking significantly correlated with the presence of LI (p≤0.05). Patients with serum calcium <9 mg/dl had higher fasting breath H2 levels and a higher proportion had a BMI >25 kg/m2 and weight >65 kg. Conclusions. The incidence of LI in CaP patients is less than that in the general population despite a higher incidence of osteoporosis, indicating a complex etiology of CaP-related osteoporosis. Certain physical characteristics and personal habits are important in determining lactose-tolerant status.

Endourologic management of forgotten encrusted ureteral stents: can ureteroscopic lithotripsy be avoided?

We present endourologic management strategies and tricks to minimize instrumentation and complications in long-indwelling encrusted stents. Seventeen patients presented with 19 retained ureteral stents (median indwelling time 3.0 y; 0.25 to 17 y). Investigations included x-ray, ultrasound, noncontrast computed tomography, excretory urography, magnetic resonance imaging, Tc99m diethylenetriaminepenta-acetic acid scan, and retrograde ureterography. Incrustation was present in all stents, encrustation 16, stone formation 11, and spontaneous fragmentation 3. All patients had gaping of ureteric orifices and dilated capacious ureters with no stent impaction. Management included extracorporeal shock wave lithotripsy (2), simple pull under fluoroscopy cystoscopically (2) and ureteroscopically (2), cystolithotripsy (10), percutaneous nephrolithotripsy (6), nephrectomy (2), and no intervention (2). In 3 patients with large encrustation burden, tubular encrustation in ureteral segment of stent could be removed intact without lithotripsy. To conclude, encrusted ureteral stents can be successfully managed using endourologic interventions. Owing to capacious ureter and nonimpacted stent, a careful attempt of pulling can be made under fluoroscopic guidance to minimize the time of ureteroscopic lithotripsy and complications thereof.

Gossypiboma of the urinary bladder.

conduct a thorough upper abdominal evaluation with computed tomography or magnetic resonance imaging if ultrasound revealed unicornuate uterus or renal agenesis associated with persistently elevated βhCG. Management options would include medical therapy if the patient was asymptomatic. This patient obviously required surgical intervention. In such cases, laparoscopy provides accurate diagnostic and therapeutic advantages for effective management [1].

Superior Mesenteric Artery Injury during en bloc Excision of a Massive Left Adrenal Tumor

Superior mesenteric artery (SMA) injury is a rare event during abdominal surgery. We report the first case of inadvertent injury of the superior mesenteric artery during surgery of a large malignant adrenocortical tumor with inferior vena cava thrombus. The cause of inadvertent injury was anatomical distortion of the great vessels due to the massive nature of the tumor. The case was managed successfully by immediate end-to-end anastomosis of the superior mesenteric artery.

Perivascular epithelioid cell tumour (PEComa) of the inferior vena cava presenting as an adrenal mass.

Abstract A 54-year-old woman had a mass located in the right suprarenal area. On imaging, this mass appeared to be infiltrating the inferior vena cava (IVC). Exploratory laparotomy was undertaken and excision of the tumour was done with the sleeve of the involved IVC. The mass turned out to be a perivascular epithelioid cell tumour (PEComa) on histopathological examination. This report describes previously reported cases of PEComa in brief and highlights the problems associated with the management of this tumour.

A Rare Case of Hydronephrotic Multicystic Dysplasia with Ipsilateral Upper Segmental Megaureter in Adults

Multicystic dysplasia in adults is a rare entity. It may present as a mass, with pain, or be detected incidentally on imaging. Here, we present a case of hydronephrotic multicystic dysplasia with ipsilateral upper segmental megaureter in an adult female patient. To the best of our knowledge, this is the first such case described in the English literature.