Nebahat Demirhan

Synthesis in solvent-free conditions, characterization and biological activity of a new Schiff-base ligand and its Cu(II) complex

A new bis-imine Schiff base (N8O2 donor, LH2) has been synthesized by melt condensation of 3-amino-1,2,4-triazole with 1,5-bis(2′-formylphenyl)-1,5-dioksapentane in 2 : 1 molar ratio, in solvent and solvent-free conditions. The ligand has been characterized using FTIR, UV–Vis, 1H NMR, 13C NMR, mass spectra, elemental analysis, and thermal (TGA-DSC) techniques. A new complex of LH2 with Cu(II) has been synthesized in solvent and solvent-free conditions. FTIR, UV–Vis mass spectra, and thermal analysis (TGA-DSC) have been used to characterize the Cu(II) complex. Thermal degradation showed that the final products were black carbon and metallic copper. Distorted octahedral geometry has been observed around CuLH2Cl2 · LH2 and its Cu(II) complex have been screened for in vitro antifungal and antioxidant activities. Antioxidation was determined for their superoxide scavenging and reducing activities. The ligand and its Cu(II) complex have strong antifungal activity against Aspergillus niger. The compounds have significant superoxide anion radical scavenging activity and reducing power against various antioxidant systems in vitro.

Synthesis and Characterization of a New Imidazole Ligand and its Complexes with Cobalt(II), Nickel(II) and Copper(II)

A new imidazole ligand, benzo[15‐crown‐5]‐1H‐imidazol[4,5‐f][1,10]phenanthroline (bip) has been synthesized from the reaction of 5,6‐diamino‐1,10‐phenanthroline with 4′‐formylbenzo‐15‐crown‐5. The Co(II), Ni(II) and Cu(II) complexes of the ligand were prepared and characterized. The metal to the ligand ratio of the Co(II), Ni(II) and Cu(II) complexes was found to be 2:1. The ligand and complexes have been characterized by FTIR, UV‐visible, 1H NMR, fluorescence spectrophotometer, elemental analyses and mass spectra.

The Synthesis, Spectroscopic, Fluorescence, and Thermal Properties of a 1,10-phenanthroline Containing Derivative of Phenoxycyclotriphosphazene and its Ru(II) Complex

A new phenoxycyclotriphosphazene derivative ligand, 2-chloro -2-salicylideneimino-1,10-phenanthrolino-4,4,6,6-bis[spiro(2′,2″-dioksi-1′,1″-bifenil)]cyclotriphosp- hazane (CS-CP), has been synthesized from the reaction of 2,2-dichloro-4,4,6,6-bis[spiro(2′,2″-dioxybiphenyl)] cyclotriphosphazane and 5-salicylideneimino-1,10-phenanthroline and Ru(II) complex of this ligand has been prepared. The newly synthesized compounds have been verified by FTIR,1H NMR, 31P NMR, UV-vis., mass, and fluorescence spectra, together with elemental and thermal analysis.

Synthesis of 4′-Acetyl(Benzo-15-Crow-5)-Oxime and Its Complexes with Copper(II), Nickel(II), Cobalt(II) and Uranyl,(VI)

Abstract A new macrocyclic ligand (HL) has been synthesized by the reaction of 4′-acetyl(benzo-15-crown-5) with hydroxylamine hydrochloride. The copper(II), nickel(II), cobalt(II) and uranyl(VI) complexes of the 4′-acetyl(benzo-15-crown-5)-oxime (16-acetylhydroxyimino-2,3,5,6,8,9,11,12-octahydrobenzo(1,4,7,10,13)pentaoxa-cyclopentadecine) have been prepared, characterized and studied potentiometrically at 25 °C, I = 1.0 M KNO3. Protonation constants of the ligand and overall formation constants have been calculated fiom potentiometric data using the program TITFIT.

Synthesis and Characterization of a Crown Ether Substitued Salicylaldiminea and its Complexes with Copper(II), Cobalt(II), Nickel(II), and Uranyl(VI)

Summary. 4′-(ω-Salicylaldiminoacetyl)benzo(15-crown-5) (LH) has been synthesized from 4′-(ω-aminoacetyl)benzo(15-crown-5) and salicylaldehyde. Complexes of this Schiff base with copper(II), nickel(II), cobalt(II), and uranyl(VI) have been prepared from the corresponding metal acetates and chlorides. Insertion of sodium ions into the crown ether-moiety has been accomplished by refluxing LH with sodium nitrate in ethanol. The complexation of this ligand with Cu(II), Ni(II), Co(II), and U(VI)O2 was investigated by potentiometric titration; the results indicate that all of them afford products with a metal-ligand ratio of 1:2. The order of formation constants of the mononuclear complexes is Cu(II)>Co(II)>U(VI)O2>Ni(II).Zusammenfassung. 4′-(ω-Salicylaldiminoazetyl)benzo(15-crown-5) (LH) wurde ausgehend von 4′-(ω-Aminoacetyl)-benzo(15-crown-5) und Salicylaldehyd synthesiert. Komplexe dieser Schiffschen Base mit Kupfer(II), Nickel(II), Kobalt(II) und Uranyl(VI) wurden aus den entsprechenden Metallacetaten hergestellt. Einfügung von Natriumionen in den Kronenetherteil der Moleküle wurde durch Kochen mit Natriumnitrat in Ethanol unter Rückfluβ erreicht. Die Komplexbildung mit Ni(II), Cu(II), Co(II) und U(VI)O2 wurde durch potentiometrische Titration untersucht; alle Metalle ergeben dieselben Komplexe mit einem Metall-Ligand-Verhältnis von 1:2. Die Reihenfolge der Bildungskonstanten der einkernigen Komplexe lautet Cu(II)>Co(II)>U(VI)O2>Ni(II).

Synthesis of bis[(4,10-diaza-4,10-ditosyl-benzo-12-crown-4) 4′-yl] diaminoglyoxime and its complexes

A new macrocyclic ligand (HL) has been synthesised by reaction of 4′-amino-4,10-diaza-4,10-ditosyl-benzo-l2-crown-4 with 1,2-dichloroethanedial-dioxime. Protonation constants of the ligand and overall formation constants have been calculated from potentiometric data using the program TITFIT. Both amino and hydroxyimino groups provide donor atoms together with hydroxyl ions at higher pH values. The order of formation constants of the mononuclear complexes are U(VI)O2>Cu(II)>Ni(II)=Co(II)>Cd(II).

Synthesis, characterization and biological activity of a new long-chain imine ligand and some transition metal complexes in solvent-free conditions

A new N-alkyl long-chain alkyl imine ligand (N-dodecyl-N1-dacanimine) has been synthesized by the reaction of dodecylamine (laurylamine) with decanal in molar 1 : 1 ratio and its Cu(I), Cu(II), Ni(II) and Co(II) complexes have been prepared under solvent-free conditions. The newly synthesized compounds have been verified by FTIR, UV-vis. and mass spectra. All of the compounds were tested for antimicrobial activity against Staphylococcus aureus ATCC 6538, meticillin resistant Staphylococcus aureus (MRSA) ATCC 33591, Staphylococcus epidermidis ATCC 12228, Escherichia coli ATCC 8739, Klebsiella pneumoniae ATCC 4352, Pseudomonas aeruginosa ATCC 1539, Proteus mirabilis ATCC 14153 and the yeast, Candida albicans ATCC 10231. Among the compounds, the ligand was found the most active compound against all strains. The Cu(II)complex exhibited very strong antibacterial activity against bacteria except for Pseudomonas aeruginosa ATCC 1539, Proteus mirabilis ATCC 14153. Also, all compounds showed very strong antifungal effects against C. albicans ATCC 10231.

SYNTHESIS AND CHARACTERIZATION OF 5,6-DIAMINO-1,10-PHENANTHROLINE SUBSTITUTED ANTI-DICHLOROGLYOXIME AND ITS COMPLEXES WITH COBALT(II), NICKEL(II), AND COPPER(II)

ABSTRACT In this study, a new dioxime ligand, 1,10-phenanthrolino-(5,6-b)-2,3-dihydyroxyimino-1,4-diazin was synthesized from the reaction of 5,6-diamino-1,10-phenanthroline with anti-dichloroglyoxime. Polymeric complexes with Ni(II), Co(II) and Cu(II) have been obtained. The new compounds have been characterized by FTIR, 1H NMR (DMSO-d6), elemental analyses and magnetic measurements. The ligand and the Ni(II), Co(II) and Cu(II) complexes have been studied potentiometrically. The metal to the ligand ratio of the Cu(II), Ni(II) and Co(II) complexes was found to be 1:1. The Co(II), Ni(II) and Cu(II) complexes of the ligand are paramagnetic. Protonation constants of the ligand and overall formation constants of the complexes have been calculated from potentiometric data using the program TITFIT.

Synthesis of N, N'-Bis[(Benzo-15-Crown-5)-Oylmethyl]Diaminoglyoxime and Its Metal Complexes

Abstract A new macrocyclic ligand (LH2) has been synthesised by the reaction of 4′-ω-aminoacetyl(benzo-15-crown-5) with anti-dichloroglyoxime (EE-diimidoyldichloride-dihydroxyethane). The crystalline complexes of the ligand (LH2) with Cu(II), Ni(II) and Co(II) has also been isolated. Protonation constants of the ligand and overall formation constants have been calculated from potentiometric data using the program TITFIT. Both amino and hydroxyimino groups provide donor atoms together with hydroxyl ions at higher pH values. The order of formation constants of the mononuclear complexes is Cu(II)>U(VI)O2>Ni(II)>Co(II)>Mn(II).

A novel water-soluble and self-doped conducting hybrid copolymer: poly(4-oxybenzenesulfonic acid)phosphazene-g-poly(3,4-ethylenedioxythiophene)

A different approach is clearly necessary to overcome the solubility problem of poly(3,4-ethylenedioxythiophene). Here, a synthetic strategy was followed to synthesize PEDOT graft arms on a polyaryloxyphosphazene platform, which is also carrying sulfonic acid co-substituents. It is found that the conductivity of the novel copolymers increases with an increase in the PEDOT level.