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Dive into the research topics where Neil Mathews is active.

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Featured researches published by Neil Mathews.


Journal of The Chemical Society-perkin Transactions 1 | 1998

Synthesis of vinyl epoxides via a three-component coupling

Martin W. Rowbottom; Neil Mathews; Timothy Gallagher

The butadienylsulfonium species 1 undergoes stepwise addition of a stabilised enolate followed by trapping of the initially formed S-ylid 2 with an aldehyde to provide vinyl epoxides 3 in a two-step, three-component process.


Journal of Medicinal Chemistry | 2004

Identification of 1,5-Naphthyridine Derivatives as a Novel Series of Potent and Selective TGF-β Type I Receptor Inhibitors

Francoise Jeanne Gellibert; James Michael Woolven; Marie-Hélène Fouchet; Neil Mathews; Helen Goodland; Victoria Lovegrove; Alain Laroze; Van-Loc Nguyen; Stéphane Sautet; Ruolan Wang; Cheryl A. Janson; Ward W. Smith; Gael Krysa; Valerie Boullay; Anne‐Charlotte le Monnier de Gouville; and Stéphane Huet; David Hartley


Journal of Medicinal Chemistry | 2006

Discovery of 4-{4-[3-(Pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): A Potent, Selective, and Orally Active Transforming Growth Factor-β Type I Receptor Inhibitor

Francoise Jeanne Gellibert; Anne‐Charlotte le Monnier de Gouville; James Michael Woolven; Neil Mathews; Van-Loc Nguyen; Cécile Bertho-Ruault; Angela Patikis; Eugene T. Grygielko; Nicholas J. Laping; Stephane Huet


Journal of Medicinal Chemistry | 1997

A novel series of 2,5-substituted tryptamine derivatives as vascular 5HT1B/1D receptor antagonists.

Gerard P. Moloney; Alan Duncan Robertson; Graeme Richard Martin; Steven MacLennan; Neil Mathews; Susan Dodsworth; Pang Yih Sang; Cameron Knight; Robert C. Glen


Journal of Medicinal Chemistry | 1999

Synthesis and Serotonergic Activity of Substituted 2,N-Benzylcarboxamido-5-(2-ethyl-1-dioxoimidazolidinyl)-N,N-dimethyltrypt- amine Derivatives: Novel Antagonists for the Vascular 5-HT1B-like Receptor

Gerard P. Moloney; Graeme Richard Martin; Neil Mathews; Aynsley Milne; Heather Hobbs; Susan Dodsworth; Pang Yih Sang; Cameron Knight; Marnie Williams; Miles Maxwell; Robert C. Glen


Journal of The Chemical Society-perkin Transactions 1 | 1999

Synthesis and serotonergic activity of 2-oxadiazolyl-5-substituted-N,N-dimethyltryptamines: novel antagonists for the vascular 5-HT1B-like receptor

Gerard P. Moloney; Graeme R. Martin; Neil Mathews; Steve MacLennan; Susan Dodsworth; Pang Yih Sang; Cameron Knight; Miles Maxwell; Robert C. Glen


Journal of The Chemical Society-perkin Transactions 1 | 1999

Synthesis and pharmacological profile of a series of 2,5-substituted-N,N-dimethyltryptamine derivatives as novel antagonists for the vascular 5-HT1B-like receptor

Gerard P. Moloney; Graeme R. Martin; Neil Mathews; Heather Hobbs; Susan Dodsworth; Pang Yih Sang; Cameron Knight; Miles Maxwell; Robert C. Glen


Journal of The Chemical Society-perkin Transactions 1 | 1999

Synthesis and serotonergic activity of a series of 2-(N-benzyl)carboxamido-5-substituted-N,N-dimethyltryptamine derivatives: novel antagonists for the vascular 5-HT1B-like receptors

Gerard P. Moloney; Graeme R. Martin; Neil Mathews; Heather Hobbs; Susan Dodsworth; Pang Yih Sang; Cameron Knight; Miles Maxwell; Robert C. Glen


Archive | 2002

Pyrazolderivate gegen tgf überexprimierung Pyrazole derivatives against tgf overexpression

Francoise Jeanne Gellibert; Neil Mathews


Archive | 2002

Pyrazolderivate gegen tgf überexprimierung Pyrazole against tgf overexpression

Francoise Jeanne Gellibert; Neil Mathews

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