Nejat Ozangüç

Recall urticaria: A case report

The appearance o f local reactions related to allergen immunothe rapy is frequent. 1, 2 These reactions very often arise as a wheal sur rounded by ery thema at the site of the injection. However , the appearance of local reactions outside the injection area is not very common. Local reactions outside the injection area quite often develop in previously injected areas. Various stimuli, including specific allergens and nonspecific stimuli, may activate local reactions in the previously injected areas. 2 This p h e n o m e n o n has been te rmed recall urticaria. 3

Nonpigmenting solitary fixed drug eruption after skin testing and intraarticular injection of triamcinolone acetonide

BACKGROUND Although several medications have been reported to cause fixed drug eruption (FDE) reactions, triamcinolone acetonide has not been previously described as an offending agent. OBJECTIVE To emphasize both an unprecedented causative agent and the extraordinary development of a FDE, we describe this response in a 42-year-old female patient. METHODS Because her history included a questionable reaction to corticosteroid preparations, prick and intradermal testing with triamcinolone acetonide was done to determine whether she could safely receive a triamcinolone acetonide injection. RESULTS Both skin test procedures and the intra-articular administration of triamcinolone acetonide caused FDEs on her right retroauricular area. CONCLUSIONS Because any drug may induce a FDE by any administration route, physicians should be aware of this delayed skin reaction when skin testing drugs.

Fever of unknown origin in a 10-year-old boy with allergic rhinitis and asthma

We believe this case represents a clear example of drug fever, and it appears to be the first report to implicate ketotifen as the responsible agent, confirmed with double rechallenge. The recognition of drug fever is clinically important. Failure to recognize the etiologic relationship between the drug and fever has unnecessary consequences, including extra testing, empiric therapy, and longer hospital stays. We suggest that ketotifen should be considered as a possible cause of fever in allergic patients receiving this drug.

İMMÜNOTERAPİYE BAĞLI ANAFLAKTİK REAKSİYONLARDA RENİN - ANGİOTENSİN SİSTEMİ

Renin Angiotensin sistemi, kan basıncı ile sıvı ve elektrolit dengesi üzerinde önemli bir rol oynamaktadır. Yapılan çalışmalarda, Hymenoptera venom anaflaksisi gösteren olgularda, Angiotensin -1 ve Angiotensin II düzeylerinin kontrol grubu bireylere oranla daha düşük olduğu gösterilmiş, bunun da anaflaksinin oluşumunda rol oynayan immünolojik olmayan faktör olduğu ve risk oluşturduğu ileri sürülmüştür (1,2,3).