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Nelson Troupe

Hoffmann-La Roche

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Featured researches published by Nelson Troupe.

Tetrahedron | 1990

Isolation and characterization of a presumed biosynthetic precursor of camptothecin from extracts of Camptotheca acuminata

Brad Carte; Charles DeBrosse; Drake S. Eggleston; Mark E. Hemling; Mary Mentzer; Benjamin Poehland; Nelson Troupe; Sidney M. Hecht

Abstract A biosynthetic precursor 4 of the antitumor alkaloid camptothecin (1) has been isolated from alkaloid enriched extracts of Camptotheca acuminata. The structure of 4, which was determined both in the solid state by x-ray diffraction and in solution by NMR analysis, provides strong evidence in support of the proposed biosynthetic scheme for camptothecin (1).

Journal of Natural Products | 1997

Three New Pseudodistomins, Piperidine Alkaloids from the Ascidian Pseudodistoma megalarva

Alan J. Freyer; Ashok D. Patil; Lew Killmer; Nelson Troupe; Mary Mentzer; Brad Carte; Leo F. Faucette; Randall K. Johnson

The Journal of Antibiotics | 1979

Isolation and characterization of antibiotic X-14547A, a novel monocarboxylic acid ionophore produced by Streptomyces antibioticus NRRL 8167.

Ralph H. Evans; Lilian H. Sello; Nelson Troupe

The Journal of Antibiotics | 1984

THE STRUCTURE AND ABSOLUTE CONFIGURATION OF THE 18-MEMBERED MACROLIDE LACTONE ANTIBIOTIC X-4357B (CONCANAMYCIN A)

Chao-Min Liu; Lilian H. Sello; Ralph H. Evans; Nelson Troupe; John F. Blount; A. M. Chiu; Louis J. Todaro; Philip A. Miller

The Journal of Antibiotics | 1983

Isolation and characterization of a novel polyether antibiotic of the pyrrolether class,antibiotic X-14885A.

Chao-Min Liu; John F. Blount; Lilian H. Sello; Nelson Troupe; Philip A. Miller

The Journal of Antibiotics | 1983

PREPARATION, PROPERTIES AND BIOLOGICAL ACTIVITY OF NATURAL AND SEMISYNTHETIC URETHANES OF MONENSIN

Chao-Min Liu; Ralph H. Evans; Lilian H. Sello; Nelson Troupe; Theron Hermann

The Journal of Antibiotics | 1981

ISOLATION AND CHARACTERIZATION OF THE FIRST HALOGEN CONTAINING POLYETHER ANTIBIOTIC X-14766A, A PRODUCT OF STREPTOMYCES MALACHITOFUSCUS SUBSP. DOWNEYI

Ralph H. Evans; Lilian H. Sello; Nelson Troupe; Chao-Min Liu; John F. Blount; Ross G. Pitcher; Thomas H. Williams; Philip A. Miller

The Journal of Antibiotics | 1981

Isolation of novel antibiotics x-14667A and x-14667B from Streptomyces cinnamonensis subsp. urethanofaciens and their characterization as 2-phenethylurethanes of monensins B and A.

Ralph H. Evans; Lilian H. Sello; Nelson Troupe; Chao-Min Liu; Philip A. Miller

The Journal of Antibiotics | 1984

Isolation and characterization of antibotic X-14931A, the naturally occurring 19-deoxyaglycone of dianemycin.

Chao-Min Liu; Lilian H. Sello; Nelson Troupe; John F. Blount; Anne-Marie Chiu; Louis J. Todaro; Philip A. Miller; Mark Liu

The Journal of Antibiotics | 1993

Isolation and characterization of four polyether antibiotics, X-14889A, B, C, and D, closely related to lysocellin and the ferensimycins.

Chao-Min Liu; John F. Blount; Louis J. Todaro; Lillian H. Sello; Nelson Troupe

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Chao-Min Liu

Hoffmann-La Roche

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Lilian H. Sello

Hoffmann-La Roche

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John F. Blount

Hoffmann-La Roche

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Philip A. Miller

Hoffmann-La Roche

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Ralph H. Evans

Hoffmann-La Roche

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Louis J. Todaro

Hoffmann-La Roche

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Brad Carte

Scripps Institution of Oceanography

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Sidney M. Hecht

Arizona State University

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Mark E. Hemling

GlaxoSmithKline

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A. M. Chiu

Hoffmann-La Roche

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