Nemallapudi Bakthavatchala Reddy

Ytterbium perfluorooctanoate [Yb(PFO)3]: a novel and efficient catalyst for the synthesis of tetrahydrobenzo[a]xanthene-11-ones under microwave irradiation

Ytterbium perfluorooctanoate [Yb(PFO)3] was found to be an efficient catalyst for the microwave assisted synthesis of tetrahydrobenzo[a]xanthene-11-ones by the one-pot condensation of 2-naphthol, aldehydes and 1,3-dicarbonyl compound under solvent-free conditions. The major advantages of this novel method are short reaction time, high yields, reusability of the catalyst and the absence of any volatile and hazardous organic solvents.

One-pot green synthesis and cytotoxicity of new α -aminophosphonates

A novel series of α-aminophosphonates containing the trifluoromethyl aniline moiety were obtained in high yields by condensation of 2-methyl-3-trifluoromethyl aniline, aryl/heteroaryl aldehydes and dimethylphosphite in the presence of chitosan as a catalyst. The molecular modeling studies revealed their important structural features of binding affinities towards the target enzyme. The cytotoxicity of these compounds was evaluated against PC-3(prostate cancer), MCF-7 (breast cancer), HeLa(cCervix Cancer), U973, K562 and HL60 human lLeukemia cell lines. Compound 4k with a pyrene moiety showed high potency against a breast cancer cell line, while compounds 4g and 4k exhibited more promising cytotoxicity against U973, K562 and HL60 cell lines.

An efficient KHSO4 catalyzed synthesis of xanthenes

Abstract KHSO4 is an efficient catalyst for the condensation of β-naphthol, aromatic aldehydes, and 5,5-dimethyl-1,3-cyclohexanedione at 100°C to afford 9,9-dimethyl-12-phenyl-8,10,11,12-tetrahydro-9H-benzo[a]xanthen-11-one derivatives in 80–95% yields.

One-pot green synthesis and bio-assay of pyrazolylphosphonates

An efficient one-pot synthesis of bioactive pyrazolylphosphonates is accomplished by the reaction of 3-methyl-1-phenyl-2-pyrazoline-5-one with various aryl aldehydes and diethyl phosphite in the presence of β-cyclodextrin (β-CD) as a catalyst. The compounds were tested for their anti-oxidant activity by DPPH and H2O2 radical scavenging assay and for anticancer activity against breast cancer (MCF-7), prostate cancer (DU-145) and lung cancer (A-549) cell lines with sulfarodamine-B (SRB) assay. Most of the synthesized compounds showed promising anti-oxidant activity and significant anticancer activity when compared with the standard drugs.

Microwave assisted synthesis and Anti-microbial activity of new Diethyl ((dialkoxyphosphoryl) (2-hydroxyphenyl) methyl) phosphoramidates

ABSTRACT The synthesis of new α-aminophosphonates 4a-j (diethyl((dialkoxyphosphoryl)(phenyl)methyl)phosphoramidates) were achieved through a one pot simple and efficient method from the three-component condensation reaction (Kabachnik-Fields reaction) of diethyl phosphoramidate, aryl salicylaldehydes, and dialkyl phosphite by using microwave irradiation under solvent-free and catalyst-free conditions in good to excellent yields and short reaction times. The structures of the novel products were established by IR, 1H, 13C & 31P-NMR and Mass spectroscopy. All the synthesized compounds were screened their antimicrobial activity. GRAPHICAL ABSTRACT