Netkal M. Made Gowda

Palladium(II)-phenothiazine complexes: synthesis and characterization

Abstract Palladium(II) chloride or nitrate complexes of phenothiazine and its derivatives have been prepared. The new complexes were characterized by their elemental analyses, molar conductivity, magnetic susceptibility and spectroscopic data. The molecular formulae of the complexes were found to be: [C12H9NS)2PdCl2]·H2O where C12H9NS = phenothiazine (PTZ); [C12H8ClNS)2PdCl2] where C12H8ClNS = 2-chlorophenothiazine (CPTZ); [(C21H27N2S2)Pd2Cl5].2H2O where (C21H27N2S2)+ = protonated thioridazine (TRH+); and [(C17H21N2S)2Pd2Cl5]NO3 where (C17H21N2S)+ = protonated promethazine (PMH+). The PM complex behaves as an electrolyte whereas the other complexes act as nonelectrolytes in solution. All the complexes are diamagnetic species. Tentative structures have been proposed.

Polynuclear rhodium complexes of phenothiazines: synthesis and characterization

SummaryPolynuclear complexes of RHII and RHIII with fiveN-alkylphenothiazines as principal ligands have been prepared. The complexes were characterized by their elemental analyses, molar conductivities, and spectral data. The molecular formulae of the new complexes are as follows: [Rh3(PTZ)2(OH2)2Cl8]Cl, where PTZ=chlorpromazine or promethazine; [Rh3(EP)2(OH2)2Cl8][Rh(OH2)2Cl4], where EP=ethopropazine; [Rh4(TF)2(OH2)5Cl9]Cl·H2O, where TF=trifluoperazine; and [Rh2(TC)3(OH2)Cl6]. H2O, where TC=2-chlorophenothiazine. A tentative structure for each of the complexes is proposed.

Synthesis and characterization of rhenium(VII) oxide complexes of phenothiazines

SummaryFive complexes of rhenium(VII) oxide with N-alkylphenothiazines have been synthesized and characterized on the basis of elemental analyses, molar conductances, and u.v.-vis., i.r. and n.m.r. spectral data. The molecular formulas of the new ionic complexes are: [ReO3(PTZ)2(H2O)][ReO4], PTZ = chlorpromazine, promethazine or ethopropazine; [ReO3(TF)(H2O)][ReO4], TF = trifluoperazine; and [ReO3(TR)3][ReO4(H2O)2]·H2O, TR = thioridazine. Tentative structures have been proposed.

Synthesis and Characterization of Iridium CHLORIDE Complexes. II. Use of Phenothiazines Without N-Alkyl Side Chain as Ligands

Abstract Iridium complexes of some phenothiazine derivatives have been prepared in MeOH or EtOH medium. The complexes have been characterized by elemental analyses, molecular weight, magnetic susceptibility, molar conductivity, and spectral data. The molecular formulas of the new complexes are [lr2(pz)5Cl4(MeOH)]CI (where pz = phenothiazine), [Ir2(cpz)4]Cl ˙MeOH (where cpz = 2-chlorophenothiazine), [lr2(apz)5Cl5]Cl ˙3MeOH (where apz = 2-acetylphenothiazine), [lr3(dopz)2Cl5(EtOH)][lr2Cl4(EtOH)2] ˙4EtOH (where dopz = 3,7-dinitro-5-oxophenothiazine) and [lr(tmpz)5Cl]Cl ˙EtOH (where tmpz = trifluoromethyl-phenothiazine).

Coordination compounds of zinc(II) and N-alkylphenothiazines: synthesis and characterization

Abstract Zinc(II) chloride/acetate complexes of title ligands have been synthesized in MeOH water medium. The compounds were characterized by their elemental analyses, molar conductivity, magnetic susceptibility, and spectroscopic data. The molecular formulas of the new complexes were found to be: [(C17H20ClN2S)4ZnCl2]Cl4 where C17H20ClN2S = protonated chlorpromazine; [(C19H25N2S)2ZnCl2]Cl2 where C19H25N2S = protonated ethopropazine; [(C17H21N2S)2ZnCl]Cl3 where C17H21N2S = protonated promethazine; [(C21H27N2S2)2ZnCl2]Cl2 .MeOH and [(C21H27N2S2)ZnCl](OAc)2 where C21H27N2S2 = protonated thioridazine; and [(C21H26F3N3S)ZnCl3]Cl where C21H26F3N3S = diprotonated trifluoperazine. All compounds are diamagnetic and ionic in nature. Structures for the complexes are proposed.

Synthesis and characterization of iridium chloride complexes: I. Use of N-alkylphenothiazine drugs as ligands

SummaryIridium complexes of N-alkylphenothiazines have been prepared in MeOH. The polynuclear complexes obtained have been characterized by elemental analyses, magnetic susceptibilities, molar conductivities, thermogravimetric analysis and spectral data. The molecular formulae of the new complexes are as follows: [Ir3(LH)4Cl10]Cl2·xMeOH, where L = chlorpromazine (CP), promethazine (PM) or ethopropazine (EP), and x = 1 for CP and 2 for PM or EP; [Ir(TFH2)2Cl4][IrCl6]·MeOH, where TF = trifluoperazine; and [Ir2(TRH)2Cl11(MeOH)]Cl·MeOH and [Ir4(TRH)3Cl15], where TR = thioridazine. The complexes are diamagnetic in nature. Tentative structures are proposed for the complexes.

Oxidimetric determination of amino acids and their metal complexes with organic monochloramines

A general back-titration method has been developed for determining amino acids in the free state and in Zn, Cd, Ni, Cu, Ba, Sr, Mn, Hg, Pb, Pd and Ag metal complexes and salts with organic monochloroamines, chloramine-T and chloramine-B. The proposed method is simple and reproducible and is useful for determining the number of amino acid ligands present in the metal complexes.

Osmium(VIII)-Catalyzed Kinetics and Mechanism of Indigo Carmine Oxidation by Chloramine-B in Basic Medium

Indigo carmine (IC) or sodium indigotin disulfonate is a natural dye that finds applications in clinical diagnosis, chemistry and biology. The osmium(VIII)-catalyzed oxidation of IC by chloramine-B (CAB) in alkaline solutions has been spectrophotometrically monitored at the indigo carmine λmax of 610 nm at 298 K. The reaction stoichiometry has been found to be 1:4 (mol:mol), resulting in the formation of major products that are the sodium salt of sulfonated anthranilic acid (SAA) and benzenesulfonamide (BSA). The reaction shows a first-order dependence of the rate on [IC], a fractional-order dependence each on [Os(VIII)] and [OH−], and a zero-order dependence each on [CAB], [BSA], and [SAA]. The variation of the ionic strength of the reaction medium has a negligible effect on the rate. Based on the effect of temperature in the range 288–313 K, activation parameters are evaluated from Arrhenius and Eyring plots. A mechanism consistent with the observed kinetic and activation data has been proposed and a rate law has been derived.

Ethopropaziniumyl cation perrhenate salt, (C19H25N2S)+[ReO4]-: synthesis and crystal structure

An unusual ethopropaziniumyl cation salt of perrhenate has been prepared and characterized using elemental analysis, molar conductance, and u.v.-vis., i.r., and nmr spectral data. The crystal and molecular structure of the new ionic compound, (EPH)[ReO4] where EPH+ is protonated ethopropazine, has been elucidated by single-crystal X-ray crystallography. Crystals are monoclinic, space groupP21/c, in a unit cell with lattice parametersa=10.866(3),b=12.242(2),c=16.01(1)°, β=109.00(1)°, volume=2014(2) Å3. The structure was solved using heavy-atom methods and refined toR=0.024 with 3181 observed reflections. In the crystal, the ethopropaziniumyl cation, which is protonated at the terminal diethylamino nitrogen, is linked to the ReO4− ion through hydrogen bonding.

Synthesis and characterization of oligomeric molybdenum complexes of N-alkylphenothiazines

SummaryPolynuclear molybdenum(IV/V) oxide - phenothiazine complexes which are oligomeric in nature have been prepared. The complexes were characterized by elemental analyses and spectroscopic data. The molecular formulae of the new complexes are [Mo4O9(OH2)2(PTZ)2], PTZ = chlorpromazine or promethazine, [Mo48(OH2)2(TR)2], TR = thioridazine, [Mo5O10(OHO2)2(EP)2], EP = ethopropazine, and [Mo6O12(OH2)2(TF)2], TF = trifluoperazine. Tentative structures are proposed.