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Neville Hubert Nicholson

Pfizer

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Publication

Featured researches published by Neville Hubert Nicholson.

Tetrahedron | 1999

PRODUCT-SUBSTRATE ENGINEERING BY BACTERIA : STUDIES ON CLAVAMINATE SYNTHASE, A TRIFUNCTIONAL DIOXYGENASE

Matthew D. Lloyd; Kirsten D. Merritt; Victor C. S. Lee; Timothy J. Sewell; Byeng Wha-Son; Jack E. Baldwin; Christopher J. Schofield; Steve W. Elson; Keith H. Baggaley; Neville Hubert Nicholson

Evidence is presented that clavaminate synthase (CS) catalyses three oxidative reactions in the clavulanic acid biosynthetic pathway. The first CS catalysed step (hydroxylation) is separated from the latter two (oxidative cyclisation and desaturation) by the action of a hydrolytic enzyme, proclavaminate amidinohydrolase, which modifies (or ‘mutates’) the sidechain of the product of the first reaction thereby converting it into a substrate for the second CS catalysed reaction.

Journal of The Chemical Society, Chemical Communications | 1994

Evidence that the immediate biosynthetic precursor of clavulanic acid is its N-aldehyde analogue

Neville Hubert Nicholson; Keith H. Baggaley; Robert Cassels; Mark Davison; Stephen W. Elson; Mark Fulston; John W. Tyler; Stefan Roland Woroniecki

(3R, 5R) Clavulanate-9-aldehyde 1 has been detected in Streptomyces clavuligerus and an NADPH dependent dehydrogenase capable of reducing 1 to clavulanic acid 2 has been isolated from this organism.

Journal of Organic Chemistry | 1997

Cycloadditions of Cephalosporins. A Comprehensive Study of the Reaction of Cephalosporin Triflates with Olefins, Acetylenes, and Dienes To Form [2 + 2] and [4 + 2] Adducts

Richard L. Elliott; Neville Hubert Nicholson; Fiona E. Peaker; Andrew K. Takle; Christine M. Richardson; John W. Tyler; Janet White; Michael J. Pearson; and Drake S. Eggleston; R. Curtis Haltiwanger

Journal of Organic Chemistry | 1994

Cycloadditions of cephalosporins. The formation of [4+2] adducts with 5-membered heterocycles

Richard L. Elliott; Neville Hubert Nicholson; Fiona E. Peaker; Andrew K. Takle; John W. Tyler; Janet White

Archive | 1999

Process for producing clavulanic acid

Keith H. Baggaley; Neville Hubert Nicholson; Stephen W. Elson; Jeffrey Edwards; Alison Jane Earl; William Henry Holms; David Michael Mousdale; Jack E. Baldwin; Christopher J. Schofield

Archive | 1993

Process for preparing clavulanic acid

Keith H. Baggaley; Alison Jane Earl; Jeffrey Edwards; Stephen W. Elson; William Henry Holms; David Michael Mousdale; Neville Hubert Nicholson

Archive | 1994

Clavulanic acid dehydrogenase, production and use for the preparation of clavulanic acid

Stephen W. Elson; Neville Hubert Nicholson; Stefan Roland Woroniecki; Janice Arnell

Archive | 1994

Carbacephalosporin compound, their preparation and use

Richard L. Elliott; Neville Hubert Nicholson; Andrew Kenneth Takle

Archive | 1994

CLAVULANIC ACID DEHYDROGENASE, PREPARATION AND USE FOR THE PRODUCTION OF CLAVULANIC ACID

Stephen W. Elson; Neville Hubert Nicholson; Stefan Roland Woroniecki; Janice Arnell

Archive | 1994

Clavulansäure-dehydrogenase, herstellung und verwendung für die herstellung von clavulansäure Clavulanic acid dehydrogenase, preparation and use for the preparation of clavulanic acid

Stephen W. Elson; Neville Hubert Nicholson; Stefan Roland Woroniecki; Janice Arnell

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Stephen W. Elson

GlaxoSmithKline

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Keith H. Baggaley

University of Oxford

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Stefan Roland Woroniecki

GlaxoSmithKline

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Alison Jane Earl

University of Bristol

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Christopher J. Schofield

University of Oxford

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John W. Tyler

GlaxoSmithKline

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Jack E. Baldwin

University of Oxford

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Andrew K. Takle

GlaxoSmithKline

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Richard L. Elliott

Pfizer

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Andrew Kenneth Takle

Pfizer

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