Nevzat Külcü

Synthesis and characterization of copper(II), nickel(II) and cobalt(II) complexes with novel thiourea derivatives

A novel series of thiourea derivatives, namely, N,N-diphenyl-N′-(4-phenyl-benzoyl)thiourea (HL1), N,N-diphenyl-N′-(4-chloro-benzoyl)thiourea (HL2) and N,N-di-n-propyl-N′-(4-chloro-benzoyl)thiourea (HL3), and its metal complexes has been prepared and characterised by elemental analysis, i.r. spectroscopy, 1H-n.m.r. spectroscopy, mass spectrometry and single crystal X-ray diffraction. The ligand coordinates to NiII, CuII and CoII in a bidentate manner yielding essentially neutral complexes of the type cis-[ML2]. N.m.r. spectra and single crystal X-ray diffraction analysis revealed the presence of a distorted tetrahedral coordination ML2 complex.

Synthesis, characterization and antimicrobial activities of transition metal complexes of N,N -dialkyl- N′ -(2-chlorobenzoyl)thiourea derivatives

N,N-di-n-propyl-N′-(2-chlorobenzoyl)thiourea (HL1) (1), N,N-diphenyl-N′-(2-chlorobenzoyl)thiourea (HL2) (2), and their NiII, CoII, CuII, ZnII, PtII, CdII and PdII complexes have been synthesized and characterized. HL1 and its copper complex were characterized by single-crystal X-ray diffraction methods. The ligands coordinate as bidentates yielding essentially neutral complexes of the type [ML2]. The complexes were screened for their in vitro antibacterial, antifungal activities and toxicity. All compounds showed antimicrobial activity, but antibacterial efficacy is greater than antifungal activity.

Crystal structure and thermal behaviour of copper(II) and zinc(II) complexes with N-pyrrolidine-N′-(2-chloro-benzoyl)thiourea

The crystal structures and thermal behaviour of bis(N-pyrrolidine-N′-(2-chloro-benzoyl)thioureato)zinc(II) (ZnL2) and its copper(II) analogue (CuL2) are reported. In both structures, the metal atoms are coordinated by two oxygen and two sulfur atoms to form neutral trans-square planar (Cu) and distorted tetrahedral (Zn) species. The thermal decomposition of the complexes was investigated by TG and DTA.

Synthesis and characterization of nickel and copper complexes with 2,2-diphenyl- N -(alkyl(aryl)carbamothioyl)acetamide: The crystal structures of HL1 and cis -[Ni(L1)2]

2,2-diphenyl-N-(R-carbamothioyl)acetamide (R = diethyl, dipropyl, dibutyl, dihexyl, diphenyl and morpholine-4) and their Ni2+ and Cu2+ complexes have been synthesized and characterized by elemental analyses, IR spectroscopy and 1H-NMR spectroscopy. The spectroscopic data are consistent with the ligand and the metal complexes containing two O, S chelated ligands. 2,2-diphenyl-N-(diethylcarbamothioyl)acetamide, HL1, and bis(2,2-diphenyl-N-(diethylcarbamothioyl)acetamido)nickel(II), Ni(L1)2, were characterized by a single crystal X-ray diffraction study. HL1 complex, C19H22N2OS, crystallizes monoclinic, space group P21/c, with Z = 4, and unit cell parameters a = 14.964(2), b = 13.026(2), c = 9.0123(15) Å, β = 96.314(4)°. Ni(L1)2 complex, C38H42N4O2S2Ni, crystallizes in monoclinic space group P21/c, with Z = 4, and unit cell parameters a = 15.434(6), b = 13.464(5), c = 17.679(7) Å, β = 108.477(11)°. The ligands coordinate bidentate to metal yielding neutral complexes of the type cis-[ML2].

Synthesis, characterization and thermal behavior of 1,1-dialkyl-3-(4-(3,3-dialkylthioureidocarbonyl)-benzoyl)thiourea and its Cu(II), Ni(II), and Co(II) complexes

We report the synthesis, characterization, and thermal behavior of 1,1-diethyl-3-(4-(3,3-diethylthioureidocarbonyl)benzoyl)thiourea, 1,1-di-n-propyl-3-(4-(3,3-di-n-propylthioureido carbonyl)benzoyl)thiourea and 1,1-di-n-butyl-3-(4-(3,3-di-n-butylthioureidocarbonyl)benzoyl)thiourea and their Ni(II), Cu(II), and Co(II) complexes. The structure of the prepared compounds was determined by elemental analysis, FT-IR, 1H NMR spectroscopy and mass spectrometry. The ligands are coordinated to metal atoms in a bidentate manner yielding an essentially neutral complex of the type M3L3. Thermal decomposition of related compounds was investigated by DTA and TG techniques. The pyrolytic end product was identified by X-ray powder diffraction method.

Synthesis, characterization, and crystal structure of 1-(4-chloro-benzoyl)-3-naphthalen-1-yl-thiourea

Abstract1-(4-Chloro-benzoyl)-3-naphthalen-1-yl-thiourea has been synthesized and characterized by elemental analysis, IR spectroscopy, and mass spectrometry. The crystal and molecular structure of the title compound has been determined from single crystal X-ray diffraction data. It crystallizes in the triclinic space group P-1, with a = 6.962(1) Å, b = 10.770(3) Å, c = 11.738(2) Å, α = 65.76(2)°, β = 80.03(1)°, γ = 84.86(2)°, and Dcalc= 1.432 g cm−1 for Z = 2. The thermal behavior of the compound has been studied by DTA and TG. The antibacterial activities of the title compound were investigated for three Gram (+) and two Gram (−) bacteria by employing broth microdilution method and subsequently, inhibitory activity against yeast-like fungi was also determined.

Synthesis and characterization of Cu(II) and Ni(II) complexes of some 4-bromo- N -(di(alkyl/aryl)carbamothioyl) benzamide derivatives

4-Bromo-N-(di-R-carbamothioyl)benzamide (R = methyl, ethyl, n-propyl, n-butyl and phenyl) ligands and their Ni(II) and Cu(II) complexes have been synthesized and characterized by elemental analyses, FT-IR and 1H-NMR spectroscopy. The crystal and molecular structure of bis(4-bromo-N-(di-n-propylcarbamothioyl)benzamido)nickel(II) has been determined from single crystal X-ray diffraction data. It crystallizes in the triclinic, space group P 1, Z = 2 with a = 9.286(2) Å, b = 13.215(3) Å, c = 14.125(3) Å, α = 64.180(5)°, β = 85.483(6)°, γ = 83.067(5)°, V = 1548.3(7) Å3 and D Calcd = 1.594 mg m−3. Loss of the N–H proton resonance and the N–H stretching vibration and the shift of the ν C=O and ν C=S stretching vibrations confirm formation of the metal complexes. These studies have shown that the metal complexes are neutral cis-[ML2].

Synthesis and Characterization of N-(Arylcarbamothioyl)-cyclohexanecarboxamide Derivatives: The Crystal Structure of N-(Naphthalen-1-ylcarbamothioyl)cyclohexanecarboxamide

A number of N-(arylcarbamothioyl)cyclohexanecarboxamide derivatives (aryl substituents: phenyl, 2-chlorophenyl, 3-chlorophenyl, 4-chlorophenyl, o-tolyl, p-tolyl, 3-methoxyphenyl, 4-methoxyphenyl and naphthalen-1yl) have been synthesized. The compounds obtained were characterized by elemental analyses, IR spectroscopy and 1H-NMR spectroscopy. N-(naphthalen-1-ylcarbamothioyl)cyclohexanecarboxamide, H2L9, was also characterized by a single crystal X-ray diffraction study. This compound, C18H20N2OS, crystallizes in the triclinic space group Pī, with Z = 2, and unit cell parameters a = 6.9921(14) Å, b = 11.002(2) Å, c = 12.381(3) Å, α = 113.28(3)°, β = 99.38(3)°, and γ = 101.85(3)°. The cyclohexane ring adopts a chair conformation. The molecular conformation of the compound is stabilized by an intramolecular (N2-H2•••O1) hydrogen bond which forms a pseudo-six-membered ring.

4-Chloro-N-[N-(6-methyl-2-pyrid­yl)car­bamo­thio­yl]benzamide

In the title compound, C14H12ClN3OS, the short exocyclic N—C bond lengths indicate resonance in the thiourea part of the molecule. The title compound is stabilized by an intramolecular N—H⋯N hydrogen bond, which results in the formation of a six-membered ring. In addition, it shows a synperiplanar conformation between the thiocarbonyl group and the pyridine group. Intermolecular N—H⋯S and C—H⋯O interactions are also present.

Thermal behaviours of Co(II), Ni(II), Cu(II)), and Pb(II) complexes of N,N-dipropyl-N′-benzoylthiourea

Abstract The Co(II), Ni(II), Cu(II)), and Pb(II) complexes of N,N-dipropyl-N′-benzoylthiourea (DPBT) are synthesised. The order, the activation energies, the entropies, and the pre-exponential factors of the thermal decomposition reactions are calculated with the thermogravimetric curves. The kinetic analysis of the thermogravimetric data was performed by using the Coats–Redfern and Horowitz–Metzger methods.