Niccolò Favaretto
University of Padua
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Publication
Featured researches published by Niccolò Favaretto.
Head and Neck-journal for The Sciences and Specialties of The Head and Neck | 2014
Gino Marioni; Stella Blandamura; Marco Lionello; Luciano Giacomelli; Andrea Lovato; Niccolò Favaretto; Stefano Breda; Giulia Tealdo; Vincenza Guzzardo; Giancarlo Ottaviano; Alberto Staffieri
Combining primary surgery with postoperative radiotherapy (RT) significantly reduces locoregional recurrence rates in selected patients with laryngeal squamous cell carcinoma (SCC). A prognostic model was used to see if associating laryngeal SCC tissue markers (mammary serine protease inhibitor [MASPIN], CD105, angiogenin [ANG], and nm23‐H1) with conventional criteria could better discriminate higher‐risk patients warranting postoperative RT.
Histopathology | 2012
Gino Marioni; Giancarlo Ottaviano; Marco Lionello; Lucia Lora; Andrea Lovato; Claudia Staffieri; Niccolò Favaretto; Luciano Giacomelli; Edoardo Stellini; Alberto Staffieri; Stella Blandamura
Marioni G, Ottaviano G, Lionello M, Lora L, Lovato A, Staffieri C, Favaretto N, Giacomelli L, Stellini E, Staffieri A & Blandamura S (2012) Histopathology Nm23‐H1 nuclear expression is associated with a more favourable prognosis in laryngeal carcinoma: univariate and multivariate analysis
Annals of Otology, Rhinology, and Laryngology | 2016
Diego Cazzador; Niccolò Favaretto; Elisabetta Zanoletti; Alessandro Martini
Objectives: Cholesteatomas can grow to a remarkable size before clinically making their presence felt. Managing giant cholesteatomas and their complications can become a challenge for the otological surgeon. Methods: We describe a case of a giant congenital cholesteatoma of the mastoid in an adult. The lesion extended to the sigmoid sinus, jugular bulb, carotid canal, occipital condyle, and the lateral portion of the first cervical vertebra. Surgical excision was performed using a combined microscopic and endoscopic surgical approach. Results: Our combined surgical technique enabled a more accurate removal of the cholesteatoma than a microscopic approach alone, with no surgical complications or damage to the structures affected by the disease. Conclusions: Using endoscopic instruments to manage giant cholesteatomas can help to avoid complications and improve surgical radicality.
American Journal of Otolaryngology | 2014
Giancarlo Ottaviano; Claudia Staffieri; Niccolò Favaretto; Elena Fasanaro; Davide Abate; Cosimo De Filippis; Alberto Staffieri; Gino Marioni
PURPOSE Burkholderia cepacia complex (Bcc) infections of the head and neck have been infrequently reported in immunocompetent patients, while their association with cystic fibrosis is quite well known. One of the main problems associated with Bcc is their intrinsic resistance to most clinically-available antimicrobials. Bcc has already been isolated in sinonasal polyposis, while here we report for the first time on its isolation in patients with chronic rhinosinusitis (CRS) but no nasal polyposis. MATERIALS AND METHODS Thirty-four consecutive surgically-treated CRS patients without cystic fibrosis were recruited. RESULTS Bcc was isolated in 4 cases of CRS without polyposis, and in another case in sinonasal polyposis. All tested Bcc strains isolated in non-polypotic CRS were resistant to ciprofloxacin, amikacin, ertapenem, amoxicillin/clavulanate, cefotaxime, and gentamicin. CONCLUSIONS The novel finding of Bcc species in CRS without polyposis as well suggests that the mechanism by which these bacteria adhere to the epithelium of the upper respiratory tract may be important in the hosts colonization.
International Journal of Biological Markers | 2016
Gino Marioni; Roberto Di Carlo; Giancarlo Ottaviano; Rocco Cappellesso; Alberto Bedogni; Rosario Marchese-Ragona; Paola Stritoni; Marco Rossi; Elisabetta Zanoletti; Niccolò Favaretto; Elisa Valentini; Federico Apolloni; Luciano Giacomelli; Alessandro Martini; Stella Blandamura
Background When advanced, oral squamous cell carcinoma (OSCC) may involve adjacent non-epithelial structures, and the prognosis is worse for bone invasion. Human relaxin-2 is a peptide hormone that has recently been associated with cancer. It can induce human osteoclast differentiation and activation, suggesting a role in tumor-driven osteolysis. This study was a preliminary assessment of the prognostic role of relaxin-2 in surgical specimens of OSCC tissue and adjacent but uninvolved mandibular/maxillary bone. Methods Relaxin-2 immunohistochemical expression and reaction intensity were assessed in tumor and uninvolved adjacent mandibular/maxillary bone specimens from 23 operated OSCC patients. Results All OSCC specimens were positive for relaxin-2. The intensity of its reaction in OSCC correlated significantly with the pattern of the tumors invasion front (p = 0.02), being higher with the infiltrative pattern. Mean relaxin-2 immunohistochemical expression was higher in patients whose OSCC recurred after treatment than those experiencing no recurrence (81.3% ± 22.6% vs. 59.5% ± 29.7%, respectively). A significant direct association emerged between relaxin-2 expression in OSCC specimens and recurrence rate (p = 0.049). Conclusions Relaxin-2 expression in OSCC should be further investigated as a potentially useful marker for identifying patients at higher risk of recurrence, who might benefit from closer follow-up and more aggressive adjuvant therapy. In other oncological settings, increasing evidence of relaxin being produced by cancer cells is prompting efforts to synthesize human relaxin-2 analogs capable of acting as antagonists and limiting tumor growth.
European Archives of Oto-rhino-laryngology | 2016
Gino Marioni; Alessandro Martini; Niccolò Favaretto; Sebastiano Franchella; Rocco Cappellesso; Filippo Marino; Stella Blandamura; Antonio Mazzoni; Elisabetta Zanoletti
Temporal bone squamous cell carcinoma (TBSCC) is an uncommon, aggressive malignancy with a poor prognosis in advanced cases. The dismal outcome is partially related to: the lack of reliable clinical or pathological prognostic factors and the largely unstandardized surgical and integrated treatments adopted. There is an undeniable need for novel diagnostic/therapeutic strategies to improve the prognosis. The purpose of this critical review was to explore the level of available knowledge concerning the molecular markers involved in the biology of TBSCC that have a prognostic potential. The Pub‐Med and Scopus electronic databases were searched without publication date limits for studies investigating molecular markers in cohorts of patients with primary TBSCC. The search terms used were: “temporal bone cancer”, “temporal bone carcinoma”, “temporal bone malignancy”, “ear cancer”, “ear carcinoma”, and “ear malignancy”. We decided preliminarily not to consider series with less than five cases. Nine retrospective case series of TBSCC were found in which different analytical techniques had been used to study the role of several biomarkers (HPV, vimentin, transforming growth factor β, CD105, RECK, matrix metalloproteinase-9, MASPIN, EBV, p16, TP53 mutation, pSTAT3, relaxin-2). CD105 expression (in tumor vessel endothelial cells) and MASPIN cytoplasmic expression (in carcinoma cells) were, respectively, found directly and inversely related with the neoplasm’s recurrence rate. CD105 expression was also inversely related with disease-free survival in TBSCC. A future goal of such analyses should be to ascertain the radio- and chemo-sensitivity profiles of individual TBSCCs, enabling truly personalized therapies. A further, more ambitious goal will be to find targets for therapeutic agents that might prove crucial in improving the disease-specific survival for patients with advanced TBSCC.
American Journal of Otolaryngology | 2015
Giancarlo Ottaviano; Stella Blandamura; Elena Fasanaro; Niccolò Favaretto; Lovato Andrea; Luciano Giacomelli; Andrea Bartolini; Claudia Staffieri; Rosario Marchese-Ragona; Gino Marioni; Alberto Staffieri
OBJECTIVES The aim of the present prospective, randomized, double-blind, and placebo-controlled investigation (approved by the Ethical Committee of Padova University Hospital [Italy]) was to assess the effect of a nasal gel containing a combination of silver sucrose octasulfate and potassium sucrose octasulfate (Silsos gel® [SG]) in wound healing after endoscopic sinus surgery (ESS) for chronic rhinosinusitis in terms of: nasal symptoms (SNOT22), endoscopic appearance of the sinonasal mucosa (Lund-Kennedy score), nasal air flow (anterior active rhinomanometry), evidence of mucosal inflammatory processes (nasal cytology and histology), and microbiological growth. METHODS Thirty-four patients with chronic rhinosinusitis were randomized on a 1:1 ratio to receive after ESS either SG or placebo (contained only the excipients [carbopol and propylene glycol] in the same concentrations as in SG). RESULTS/CONCLUSIONS Judging from the present prospective investigation on patients who underwent ESS for chronic rhinosinusitis, treatment with SG seems to enable a significantly faster improvement in specific symptoms (assessed on the validated SNOT22 scale) than placebo. Patients treated with SG also had a quicker improvement in the endoscopic appearance of their nasal mucosa after ESS than patients treated with placebo. These endoscopic improvements in the SG group were also confirmed at the long-term follow-up, while the same did not apply to the placebo-treated group.
American Journal of Otolaryngology | 2015
Niccolò Favaretto; Elena Fasanaro; Alberto Staffieri; Rosario Marchese-Ragona; Claudia Staffieri; Luciano Giacomelli; Roberto Stramare; Giancarlo Ottaviano; Gino Marioni
OBJECTIVES Before the widespread use of antibiotics, most deep neck infections (DNIs) stemmed from complicated pharyngeal infections. Nowadays, they seem to be due mainly to dental infections. In 2010, our group reported that DNIs originated from a major salivary gland in 14% of cases. The main endpoint of the present investigation was to review our experience of the diagnosis and treatment of DNIs of salivary gland origin. We also compared the characteristics of DNIs originating from salivary glands with those originating elsewhere. METHODS Between 2000 and 2011, 44 patients were treated for DNIs of salivary origin at our institution. These patients were compared with 191 cases of DNI diagnosed as having other sites of origin. RESULTS/CONCLUSIONS In the present series, DNIs originating from a major salivary gland accounted for 19% of all cases of DNI of known origin. Patients with DNI of salivary gland origin were more likely to be elderly than those whose DNI originated from elsewhere (p=0.000). Our multivariate statistical model showed that comorbidities (p=0.051, statistical trend) and the need for surgical treatment (p=0.028) independently predicted long-term hospitalization for DNIs originating from a major salivary gland.
European Archives of Oto-rhino-laryngology | 2015
Giancarlo Ottaviano; Rocco Cappellesso; Ioannis Mylonakis; Marco Lionello; Niccolò Favaretto; Luciano Giacomelli; Cristiano Spoladore; Rosario Marchese-Ragona; Filippo Marino; Alberto Staffieri; Alessandro Martini; Gino Marioni
European Archives of Oto-rhino-laryngology | 2014
Claudia Staffieri; Elena Fasanaro; Niccolò Favaretto; Fabio Biagio La Torre; Saverio Sanguin; Luciano Giacomelli; Filippo Marino; Giancarlo Ottaviano; Alberto Staffieri; Gino Marioni