Nicholas Caplanis

Platelet-rich plasma application in sinus graft surgery: Part I--Background and processing techniques.

The uses of cytokine growth factors in soft tissue applications has been reported on. The scientific background and various processing techniques to prepare the autologous materials are reviewed here. An ongoing research project to study grafting of the maxillary sinus for bone regeneration and implant site preparation with the growth factor Platelet Rich Plasma is outlined.

Bone Formation in the Maxillary Sinus by Using Platelet-rich Plasma: An Experimental Study in Sheep

Recently, platelet-rich plasma (PRP) has been proven to be an effective regeneration adjunct when combined with autogenous bone in the reconstruction of mandibular defects. However, little is known about the effect of PRP when combined with a bone allograft in the maxillary sinus. The purpose of this study was to quantitatively evaluate the ability of PRP to enhance bone regeneration in the maxillary sinus of sheep when combined with demineralized freeze-dried bone allograft (DFDBA) and cortical cancellous freeze-dried bone allograft (CCFDBA). Ten sheep were selected for bilateral sinus augmentation DFDBA + CCFDBA + PRP (test) and DFDBA + CCFDBA (control). Five were sacrificed at 3 months and the other 5 at 6 months. Hematology tests were performed for platelet count, and histology slides were obtained for histomorphometric analysis taking 2 measures of interest: total area (square millimeters) and percentage of bone fill. Student t tests showed no significant difference between test and control groups for total area (P > .25) and percentage of bone fill (P > .80) at either 3 or 6 months. The control group showed no statistical difference for total area (P < .095) and percentage of bone fill (P <.60) between 3- and 6-month healing times. The test group, however, showed a significant increase in total area (P <.025) but not in percentage of bone fill (P <.40) for the 2 healing periods. When the treatments were compared for interactions within the animal model, no clear tendency was evident for the test group to perform in relation to the control group regarding total area (r = .766, P < .01). A moderate tendency existed between the percentages of bone filled (r = .824, P < .005). Platelet-rich plasma showed higher platelet count than did the whole blood (2 to 5 times). However, no correlation was found between the log ratio and the bone measures. Within the limitations of this study, PRP failed to enhance or accelerate bone regeneration in the maxillary sinus of sheep when combined with bone allograft.

Immediate Loading of a Single Hydroxyapatite-Coated Threaded Root Form Implant: A Clinical Report

The successful results of endosseous root form implants in the treatment of partially and completely edentulous patients has been made possible by the application of standardized surgical and prosthetic protocols. Different techniques have been published in the literature with the purpose of reducing implant prosthetic rehabilitation times. This clinical case report describes a new surgical concept and a technique to fabricate screw-retained provisional crowns for immediate loading of free-standing single tooth implants. Further clinical and histologic studies are necessary in order to promote routine clinical application of this technique.

Effect of teeth with periradicular lesions on adjacent dental implants

OBJECTIVES It is generally accepted that dental implants should not be placed in infected sites. However, the effect of periradicular infections of natural teeth on adjacent osseointegrated implants is less understood. The purpose of this study was to evaluate effects of periradicular lesions on osseointegration of existing implants. Study design Forty titanium solid root-form implants were placed close to premolars in dogs. After healing following implant placement, the adjacent premolars were treated in 1 of 4 ways: group A, no treatment of the adjacent premolar; group B, induction of a periradicular lesion followed by nonsurgical root canal therapy of the premolar; group C, induction of a periradicular lesion followed by nonsurgical root canal therapy of the premolar and surgical detoxification of the implant surface; and group D, induction of periradicular lesion and no treatment of the tooth. After 7(1/2) months, block sections were prepared and the percentage of osseointegration was analyzed histomorphometrically. RESULTS The average integration for implants in groups A-B was 54%, 74%, 56%, and 68%, respectively. One-way analysis of variance demonstrated no difference between the 4 groups ( P =.518). CONCLUSIONS The results of this study indicate that teeth with periradicular lesions do not adversely affect adjacent titanium solid root-form implants.

Simultaneous vertical guided bone regeneration and guided tissue regeneration in the posterior maxilla using recombinant human platelet-derived growth factor: a case report.

This clinical case report describes and demonstrates successful use of recombinant human platelet-derived growth factor (rhPDGF-BB) in conjunction with autogenous bone, anorganic bone mineral, and barrier membranes to reconstruct severe alveolar bone defects. A combined sinus augmentation and vertical alveolar ridge augmentation was successfully performed. In addition, a significant amount of periodontal bone gain was achieved in close apposition to a previously denuded root surface, which is significant from a periodontal standpoint, given the possibility of vertical periodontal regeneration.

Impact Factors in Scientific Journals: Keeping a Balance for the JOI Readers

Editor-in-Chief: James L. Rutkowski, DMD, PhD* Senior Editor: Sheldon Winkler, DDS Editor Emeritus: Robert J. Buhite, DDS Senior Associate Editors: Sebastiano Andreana, DDS, MS; H. Dexter Barber, DDS; Nicholas Caplanis, DMD, MS; Dennis Flanagan, DDS; John Kern, PhD; Jaime Lozada, DDS; Craig M. Misch, DDS, MDS; Harold F. Morris, DDS, MS; Nicholas Radio, PhD; James Ference, DMD; David M. Dohan Ehrenfest, DDS, PhD* Literature Review Editor: Omar Bayati, MDS, BDS Editorial Board: Barry Bartee, DDS, MD; Kim Gowey, DDS; Richard Guaccio, DDS; Brian Jackson, DDS; Ahmad Kutkut, DDS, MS; Pankaj Narkhede, DDS, MDS, BDS; John Nase, DDS Guest: Lidia M. Dohan Ehrenfest, EPhil, EM