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Dive into the research topics where Nicholas Greeves is active.

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Featured researches published by Nicholas Greeves.


Tetrahedron Letters | 2002

Three component synthesis of homoallylic amines. Efficient catalysis by lanthanum triflate/benzoic acid

Helen C. Aspinall; James S Bissett; Nicholas Greeves; Daniel Levin

Abstract Lanthanum triflate–benzoic acid catalyses the in situ formation and allylation of various imines from aldehydes and an aromatic amine.


Tetrahedron Letters | 1999

Catalytic, asymmetric cyanohydrin synthesis mediated by lanthanide(III) chloride pybox complexes

Helen C. Aspinall; Nicholas Greeves; Peter M. Smith

Abstract Complexes formed between lanthanide trichlorides and 2,6-bis( substituted -2-oxazolin-2-yl)pyridine (pybox) ligands are effective catalysts for the enantioselective addition of trimethylsilylcyanide (TMSCN) to a range of aldehydes.


Tetrahedron Letters | 1998

Ytterbium triflate catalysed allylation of aldehydes: An unusual benzoic acid induced acceleration

Helen C. Aspinall; Nicholas Greeves; Edward G. McIver

Abstract Addition of one equivalent of benzoic acid greatly enhances the efficiency of our ytterbium triflate catalyzed allylation of aldehydes with allyltributyltin in acetonitrile. Crucial modifications to reaction conditions result in a dramatically increased rate at remarkably low catalyst loading.


Tetrahedron Letters | 1994

Ytterbium trifluoromethanesulfonate [Yb(OTf)3] as a novel catalyst for the allylation of aldehydes

Helen C. Aspinall; Andrew F. Browning; Nicholas Greeves; Paul Ravenscroft

Abstract Ytterbium triflate has been found to be an excellent Lewis acid catalyst for the reaction of aldehydes with allyltributylstannane.


Tetrahedron Letters | 2002

Lanthanum triflate-catalysed allylation of aldehydes: crucial activation by benzoic acid

Helen C. Aspinall; James S Bissett; Nicholas Greeves; Daniel Levin

Abstract Lanthanum triflate in combination with benzoic acid catalyses the allylation of aldehydes at low catalyst loading, without the need to activate the catalyst in advance.


Tetrahedron Letters | 1992

Ultrasound assisted preparation of organocerium reagents

Nicholas Greeves; Lisa Lyford

Abstract Sonication of anhydrous CeCl 3 in tetrahydrofuran facilitates rapid preparation of organocerium reagents.


Tetrahedron Letters | 1997

An improved Williamson etherification of hindered alcohols promoted by 15-crown-5 and sodium hydride

Helen C. Aspinall; Nicholas Greeves; Wai-Man Lee; Edward G. McIver; Peter M. Smith

Abstract 15-crown-5 greatly facilitates Williamson ether synthesis when sodium hydride base is used in THF solvent. This mild yet versatile procedure has been employed in the synthesis of new homochiral polyether ligands and bis-allylic ethers which are inaccessible by conventional methods.


Journal of Organometallic Chemistry | 2002

Defining effective chiral binding sites at lanthanides—highly enantioselective reagents and catalysts from binaphtholate and pybox ligands

Helen C. Aspinall; Nicholas Greeves

This paper reviews our work with enantioselective lanthanide reagents and catalysts for organic synthesis. Heterometallic reagents M3[Ln(binol)3 ]( M=Li; Ln=lanthanide; H2binol= binaphthol) mediate the addition of RLi to aldehydes with ee’s of up to 84%. Structural studies have been carried out where M = Li or Na, Ln= Eu, Y or Yb and with enantiomerically pure or racemic binol. There are important differences in coordination chemistry dependent on the ionic radius of M and Ln. [LnCl3(pybox)2] are effective catalysts for the silylcyanation of aldehydes, giving ee’s of up to 89% under convenient reaction conditions. Structural studies have been undertaken on [Ln(OTf)3(Pr i pybox)2] for Ln= La, Eu or Yb.


Tetrahedron Letters | 1984

Synthesis of single isomers (E or Z) of unsaturated alcohols by the Horner-Wittig reaction

Antony D. Buss; Nicholas Greeves; Daniel Levin; Paul Wallace; Stuart Warren

Abstract Single isomers ( E or Z ) of homoallylic and higher alcohols can be synthesised from ω-hydroxyalkyldiphenylphosphine oxides and aldehydes, or from alkyldiphenylphosphine oxides and lactones


Tetrahedron Letters | 1996

ENANTIOSELECTIVE ADDITION OF ORGANOCERIUM REAGENTS TO ALDEHYDES : EFFECTS OF TADDOL LIGAND STRUCTURE

Nicholas Greeves; J.Elizabeth Pease; Martin Charles Bowden; Stephen Martin Brown

Abstract A range of TADDOL organocerium reagents have been prepared and the effect of TADDOL structure on their enantioselective addition to aldehydes has been studied.

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Wai-Man Lee

University of Liverpool

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