Nicholas Phillip Mulholland
Syngenta
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Publication
Featured researches published by Nicholas Phillip Mulholland.
Angewandte Chemie | 2016
Katherine M. Williams; Agnieszka J. Szwalbe; Nicholas Phillip Mulholland; Jason Leigh Vincent; Andy M. Bailey; Christine L. Willis; Thomas J. Simpson; Russell J. Cox
Abstract Fungal maleidrides are an important family of bioactive secondary metabolites that consist of 7, 8, or 9‐membered carbocycles with one or two fused maleic anhydride moieties. The biosynthesis of byssochlamic acid (a nonadride) and agnestadride A (a heptadride) was investigated through gene disruption and heterologous expression experiments. The results reveal that the precursors for cyclization are formed by an iterative highly reducing fungal polyketide synthase supported by a hydrolase, together with two citrate‐processing enzymes. The enigmatic ring formation is catalyzed by two proteins with homology to ketosteroid isomerases, and assisted by two proteins with homology to phosphatidylethanolamine‐binding proteins.
Archive | 2011
Nicholas Phillip Mulholland; Edouard Godineau; Jérôme Yves Cassayre; Peter Renold; Qacemi Myriem El; Guillaume Revol
Chemical Communications | 2015
Agnieszka J. Szwalbe; Katherine M. Williams; Daniel E. O'Flynn; Andy M. Bailey; Nicholas Phillip Mulholland; Jason Leigh Vincent; Christine L. Willis; Russell J. Cox; Thomas J. Simpson
Archive | 2011
Qacemi Myriem El; Helmars Smits; Jérôme Yves Cassayre; Nicholas Phillip Mulholland; Peter Renold; Edouard Godineau; Thomas Pitterna
Chemical Communications | 2017
Katherine M. Williams; Agnieszka J. Szwalbe; Claire L. Dickson; Tim R. Desson; Nicholas Phillip Mulholland; Jason Leigh Vincent; John Martin Clough; Andy M. Bailey; Craig P. Butts; Christine L. Willis; Thomas J. Simpson; Russell J. Cox
Angewandte Chemie | 2016
Katherine M. Williams; Agnieszka J. Szwalbe; Nicholas Phillip Mulholland; Jason Leigh Vincent; Andy M. Bailey; Christine L. Willis; Thomas J. Simpson; Russell J. Cox
Chemical Science | 2018
Kate de Mattos-Shipley; Claudio Greco; David M. Heard; Gemma Hough; Nicholas Phillip Mulholland; Jason Leigh Vincent; Jason Micklefield; Thomas J. Simpson; Christine L. Willis; Russell J. Cox; Andy M. Bailey
Archive | 2016
Myriem El Qacemi; Helmars Smits; Jérôme Yves Cassayre; Nicholas Phillip Mulholland; Peter Renold; Edouard Godineau; Thomas Pitterna
Archive | 2015
Alaric James Avery; Alain De Mesmaeker; Nicholas Phillip Mulholland; Nigel James Willetts; Paul Anthony Worthington
Archive | 2013
Nigel James Willetts; Nicholas Phillip Mulholland; Paul Anthony Worthington; Alaric James Avery
