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Dive into the research topics where Nicholas W. DiTullio is active.

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Featured researches published by Nicholas W. DiTullio.


Journal of Medicinal Chemistry | 1977

Mercapto heterocyclic carboxylic acids, analogues of 3-mercaptopicolinic acid.

Benjamin Blank; Nicholas W. DiTullio; Franklin F. Owings; Linda Deviney; Clara K. Miao; Harry L. Saunders

3-Mercaptopicolinic acid (3-MPA), a potent hypoglycemic agent in fasted rats, provided the impetus for substituting this compound with a 5-mercapto group (1), a 6-carboxyl group (2), and a 5-mercapto and 6-carboxyl group (3) and for replacing the pyridine ring with other heterocycles: quinoline (4), thiazole (5), pyrazine (6), isoquinoline (7), and indole (8). The methyl sulfoxide (9) and sulfone (10) of 3-MPA were also prepared. The new compounds 1-10, with the exception of 8, did not lower blood glucose levels in 48-h fasted rats. 8 was toxic at doses which were hypoglycemic.


Journal of Medicinal Chemistry | 1974

Mercaptopyridinecarboxylic acids. Synthesis and hypoglycemic activity

Benjamin Blank; Nicholas W. DiTullio; Clara K. Miao; Franklin F. Owings; Gleason Jg; Ross St; Berkoff Ce; Harry L. Saunders


Journal of Medicinal Chemistry | 1978

Synthesis and hypoglycemic activity of some substituted 2-arylthiazolo[3,2-a]pyridinium salts.

Benjamin Blank; Nicholas W. DiTullio; Arnold J. Krog; Harry J. Saunders


Journal of Pharmaceutical Sciences | 1967

N-aralkyl-N-methylaminoethyl carbanilates as hypocholesteremic agents

William J. Rost; Elaine M. Sutton; Benjamin Blank; Francis R. Pfeiffer; William L. Holmes; Nicholas W. DiTullio; Edwin B. Ingram


Journal of Medicinal Chemistry | 1979

Synthesis and hypoglycemic activity of pyridyl alcohols.

Benjamin Blank; Nicholas W. DiTullio; Arnold J. Krog; Harry L. Saunders


Journal of Medicinal Chemistry | 1975

Synthesis and hypoglycemic activity of phenacyltriphenylphosphoranes and phosphonium salts.

Benjamin Blank; Nicholas W. DiTullio; Linda Deviney; John T. Roberts; Harry L. Saunders


Journal of Medicinal Chemistry | 1977

Synthesis and hypoglycemic activity of 4-substituted 3-mercaptopicolinic acids

Benjamin Blank; Nicholas W. DiTullio; Linda Deviney; John T. Roberts; Magnani A; Billig M; Harry L. Saunders


Journal of Medicinal Chemistry | 1977

Synthesis and hypoglycemic activity of S-acyl derivatives of 3-mercaptopicolinic acid.

Benjamin Blank; Nicholas W. DiTullio; Linda Deviney; John T. Roberts; Harry L. Saunders


Archive | 1974

Lowering the concentration of plasma triglycerides

Nicholas W. DiTullio; Charles Patrick Lowman; Alfred Roland Maass; Harry L. Saunders


Archive | 1976

HYPOLIPIDEMIC COMPOSITIONS AND METHOD OF PRODUCING HYPOLIPIDEMIC ACTIVITY

Ditullio Nicholas William; Nicholas W. DiTullio; Lowman Charles Patrick; Charles Patrick Lowman; Maass Alfred Roland; Alfred Roland Maass; Saunders Harry Link; Harry L. Saunders

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Benjamin Blank

University of Missouri–Kansas City

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Edwin B. Ingram

University of Missouri–Kansas City

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Elaine M. Sutton

University of Missouri–Kansas City

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Francis R. Pfeiffer

University of Missouri–Kansas City

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William J. Rost

University of Missouri–Kansas City

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William L. Holmes

University of Missouri–Kansas City

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