Nicholas W. DiTullio
University of Missouri–Kansas City
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Publication
Featured researches published by Nicholas W. DiTullio.
Journal of Medicinal Chemistry | 1977
Benjamin Blank; Nicholas W. DiTullio; Franklin F. Owings; Linda Deviney; Clara K. Miao; Harry L. Saunders
3-Mercaptopicolinic acid (3-MPA), a potent hypoglycemic agent in fasted rats, provided the impetus for substituting this compound with a 5-mercapto group (1), a 6-carboxyl group (2), and a 5-mercapto and 6-carboxyl group (3) and for replacing the pyridine ring with other heterocycles: quinoline (4), thiazole (5), pyrazine (6), isoquinoline (7), and indole (8). The methyl sulfoxide (9) and sulfone (10) of 3-MPA were also prepared. The new compounds 1-10, with the exception of 8, did not lower blood glucose levels in 48-h fasted rats. 8 was toxic at doses which were hypoglycemic.
Journal of Medicinal Chemistry | 1974
Benjamin Blank; Nicholas W. DiTullio; Clara K. Miao; Franklin F. Owings; Gleason Jg; Ross St; Berkoff Ce; Harry L. Saunders
Journal of Medicinal Chemistry | 1978
Benjamin Blank; Nicholas W. DiTullio; Arnold J. Krog; Harry J. Saunders
Journal of Pharmaceutical Sciences | 1967
William J. Rost; Elaine M. Sutton; Benjamin Blank; Francis R. Pfeiffer; William L. Holmes; Nicholas W. DiTullio; Edwin B. Ingram
Journal of Medicinal Chemistry | 1979
Benjamin Blank; Nicholas W. DiTullio; Arnold J. Krog; Harry L. Saunders
Journal of Medicinal Chemistry | 1975
Benjamin Blank; Nicholas W. DiTullio; Linda Deviney; John T. Roberts; Harry L. Saunders
Journal of Medicinal Chemistry | 1977
Benjamin Blank; Nicholas W. DiTullio; Linda Deviney; John T. Roberts; Magnani A; Billig M; Harry L. Saunders
Journal of Medicinal Chemistry | 1977
Benjamin Blank; Nicholas W. DiTullio; Linda Deviney; John T. Roberts; Harry L. Saunders
Archive | 1974
Nicholas W. DiTullio; Charles Patrick Lowman; Alfred Roland Maass; Harry L. Saunders
Archive | 1976
Ditullio Nicholas William; Nicholas W. DiTullio; Lowman Charles Patrick; Charles Patrick Lowman; Maass Alfred Roland; Alfred Roland Maass; Saunders Harry Link; Harry L. Saunders