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Dive into the research topics where Nico Michaelis is active.

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Featured researches published by Nico Michaelis.


Biomacromolecules | 2009

Biofunctional surfaces based on dendronized cellulose.

Matthias Pohl; Nico Michaelis; Frank Meister; Thomas Heinze

Biofunctionalized surfaces based on dendronized cellulose were prepared either by embedding 6-deoxy-6-(1,2,3-triazolo)-4-polyamidoamine (PAMAM) cellulose (degree of substitution, DS 0.25), obtained by homogeneous conversion of 6-deoxy-6-azido cellulose with propargyl-PAMAM dendron via the copper-catalyzed Huisgen reaction, in a cellulose acetate (DS 2.50) matrix or by the heterogeneous functionalization of deoxy-azido cellulose film with the dendron. The amount of amino groups provided by the solid supports was determined and the covalent attachment of enzyme was proven with glucose oxidase as model enzyme after activation with glutardialdehyde. The quality of glucose oxidase immobilization was defined by determining of the specific enzyme activity, coupling efficiency, storage stability, and reproducibility. Although the heterogeneous functionalization of the deoxy-azido film yields a product that binds more enzyme compared to the blend of dendronized cellulose derivative with cellulose acetate, the coupling efficiency is comparatively small. Nevertheless, the different approaches for the preparation of biofunctionalized surfaces based on dendronized cellulose provide an excellent reproducibility and good storage stability.


Angewandte Chemie | 2011

Protein-like oligomerization of carbohydrates.

Thomas Heinze; Melanie Nikolajski; Stephan Daus; Tabot M. D. Besong; Nico Michaelis; Peter Berlin; Gordon A. Morris; Arthur J. Rowe; Stephen E. Harding

Sugar can, too: Many proteins form noncovalent and thermodynamically reversible oligomers, which can dictate a proteins functionality. For the first time, the presence of multiple oligomeric forms is shown in a whole class of polymeric carbohydrates, the 6-deoxy-6-aminocelluloses, using analytical ultracentrifugation as a probe.


Macromolecular Symposia | 2009

Unconventional Cellulose Products Through Nucleophilic Displacement Reactions

Katrin Petzold-Welcke; Nico Michaelis; Thomas Heinze


Cellulose | 2011

Protonation behavior of 6-deoxy-6-(2-aminoethyl)amino cellulose: a potentiometric titration study

Lidija Fras Zemljič; Duško Čakara; Nico Michaelis; Thomas Heinze; Karin Stana Kleinschek


Archive | 2013

Biopolymer-based flexible-tube type food casing with internal impregnation

Matthias Pohl; Nico Michaelis


Angewandte Chemie | 2011

Proteinähnliche Oligomerisierung von Kohlenhydraten

Thomas Heinze; Melanie Nikolajski; Stephan Daus; Tabot M. D. Besong; Nico Michaelis; Peter Berlin; Gordon A. Morris; Arthur J. Rowe; Stephen E. Harding


ChemInform | 2009

Polysaccharide Derivatives for the Modification of Surfaces by Self-Assembly

Thomas Heinze; Stephanie Hornig; Nico Michaelis; Katrin Schwikal


Archive | 2013

Tubular foodstuff casing based on biopolymers with internal impregnation, as well as method for its manufacture

Matthias Pohl; Nico Michaelis


Archive | 2013

Schlauchförmige Nahrungsmittelhülle auf Basis von Biopolymeren mit Innenimprägnierung

Matthias Pohl; Nico Michaelis


Archive | 2012

The tubular food casing based on biopolymers with internal impregnation

Matthias Pohl; Nico Michaelis

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Arthur J. Rowe

University of Nottingham

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Frank Meister

Technische Universität Ilmenau

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