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Nicolae Manolescu

University of Agricultural Sciences, Dharwad

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Featured researches published by Nicolae Manolescu.

BioMed Research International | 2015

Immunohistochemical Expression of Ornithine Decarboxylase, Diamine Oxidase, Putrescine, and Spermine in Normal Canine Enterocolic Mucosa, in Chronic Colitis, and in Colorectal Cancer

Giacomo Rossi; Matteo Cerquetella; G. Pengo; Subeide Mari; Emilia Balint; Gabrio Bassotti; Nicolae Manolescu

We compared the immunohistochemical expression of putrescine (PUT), spermine (SPM), ornithine decarboxylase (ODC), and diamine oxidase (DAO) in bioptic samples of canine colonic mucosa with chronic inflammation (i.e., granulomatous colitis and lymphoplasmacytic colitis) or neoplasia. Single and total polyamines levels were significantly higher in neoplastic tissue than in normal samples. Samples with different degrees of inflammation showed a general decrease expression of ODC if compared to controls; SPM was practically not expressed in control samples and very low in samples with chronic-granulomatous inflammation. In carcinomatous samples, the ODC activity was higher with respect to controls and samples with inflammation. This is the first description of polyamines expression in dog colonic mucosa in normal and in different pathological conditions, suggesting that the balance between polyamine degradation and biosynthesis is evidently disengaged during neoplasia.

Journal of Biotechnology | 2017

One Health and advanced biotechnology

Nicolae Manolescu; Emilia Balint; Sabin Cinca; Calin Cristian Chirila

1 “Prof. Dr. Alex.Trestioreanu” Oncological Institute, Bucharest, Romania 2 Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine, Bucharest, Romania 3 One Health – New Medical Concept Association, Bucharest, Romania Corresponding author: Nicolae Manolescu “Prof. Dr. Alex.Trestioreanu” Oncological Institute, Bucharest, Romania. E-mail:[email protected] Abstract

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Veterinary Medicine | 2007

MORPHOCYTOLOGICAL SIMILITUDE IN THE COMPARATIVE STUDY OF MALIGNANT HEMOPATHIES IN DOGS AND HUMANS

Emilia Balint; Nicolae Manolescu

The necessity and the importance on tackling this subject is due to the presence of this cancer forms (leukemias and malignant lymphomas) in humans and in animals, but with a greater incidence in companion animals (dogs, cats) and mostly in dogs. Following the epidemiologic, anatomy-pathology and evolution studies, mainly stressing the hematological aspects and the problems relied on the cellular basis of the malignant proliferation, were observed that they have very many resemblances with those for humans

Romanian Biotechnological Letters | 2010

Characterization of Pasteurella sp. strains by macrorestriction profiles of PFGE bands from oral swab samples.

Simona Ivana; Gheorghe Câmpeanu; Nicolae Manolescu; Ionita Lucian; Emilia Balint; Carmen Ionita; Ipate Iudith; Alexandru Nicolae Popescu

Archive | 2005

Deuterium Depleted Water (Ddw) Using As Adjuvant In Cancer Therapy For Cytostatics Toxicity Reducing

Nicolae Manolescu; Serban Constantin Valeca; Rodica Anghel; Ion Balanescu; Rodin Traicu; Dumitru Marculescu; Ioan Stefanescu; Marieta Panait; Emilia Balint; Ioan Encut; Manuella Militaru; Aneta Pop; Sabin Cinca; Virgiliu Comisel; Viorel Fugaru; Corneliu Mateescu; Iuliana Gruia; Victoria Moraru; Monica Nistoroiu; Daniela Begu; Iolanda Dumitrescu; Maria Ghita

Journal of Biotechnology | 2018