Nicole Knöpfel

Timolol for the treatment of pyogenic granuloma (PG) in children

THERAPEUTIC CHALLENGE Pyogenic granuloma (PG) is a rapidly growing benign vascular tumor that commonly affects children younger than 5 years of age and mainly occurs on the head and upper extremities. Clinical presentation consists of a small, friable, red papule or nodule and because of its tendency to bleed, removal of this benign vascular tumor is often sought. To avoid procedure-associated anesthesia and scarring in children, topical timolol has been proposed as a potential treatment for this condition.

Dermoscopic Visualization of Vellus Hair Involvement in Tinea Corporis: A Criterion for Systemic Antifungal Therapy?

Dermoscopy has been shown to be a valuable tool in the diagnosis and monitoring of several infectious diseases. We report a case of tinea corporis in an infant in whom dermoscopy helped us to determine vellus hair involvement, causing treatment to be switched from topical to systemic antifungal therapy.

Erythema multiforme after orf virus infection

The case of a 6‐year‐old boy with multiple, target‐shaped lesions and a crusted nodule on his right index finger is presented. Based on clinical findings and the patients recent contact with sheep and goats, a diagnosis of orf disease associated with erythema multiforme was suspected. Microscopy studies confirmed the presence of parapoxvirus in the primary lesion. Orf‐induced erythema multiforme is a rare complication of orf in children, possibly related to the presence of orf virus DNA in erythema multiforme lesions.

Methotrexate for severe nummular eczema in children: Efficacy and tolerability in a retrospective study of 28 patients

Nummular eczema in children is a chronic condition characterized by pruritic coin‐shaped eczematous lesions that affect any part of the body and often become exudative. Mid‐ to high‐potency topical corticosteroids are considered the mainstay treatment, but there are limited data on the use of systemic therapy for nummular eczema in children. The objective of the current study was to evaluate the efficacy and safety of methotrexate in children with severe nummular eczema.

Ultrasound findings in idiopathic facial aseptic granuloma: Case series and literature review

Idiopathic facial aseptic granuloma is an inflammatory nodule commonly located on the cheeks and eyelids in young children. Despite its prolonged course, it tends toward spontaneous resolution, so invasive diagnostic procedures should be avoided. Cutaneous ultrasound is a noninvasive modality that has been found to improve the diagnostic accuracy of nodular skin lesions. We report five children with idiopathic facial aseptic granuloma in whom high‐resolution ultrasound examination provided distinctive findings.

Identical COL71A1 heterozygous mutations resulting in different dystrophic epidermolysis bullosa phenotypes

Dystrophic epidermolysis bullosa is a rare blistering condition caused by mutations in the COL7A1 gene. Different clinical variants have been described, with dominant and recessive inheritance, but no consistent findings have been elucidated to establish a genotype–phenotype correlation. We present three unrelated patients with two identical pathogenic compound heterozygous mutations in the COL7A1 gene that developed different clinical forms of dystrophic epidermolysis bullosa—epidermolysis bullosa pruriginosa and mild recessive non‐Hallopeau–Siemens—raising the possibility of other genetic or environmental modifying factors responsible for the phenotype of the disease.

Pruritic reticulated eruption

A 16-year-old girl presented with intensely pruritic skin lesions of 1-month’s duration that had first appeared in the summer and had subsequently spread to form a symmetrical eruption on the dorsallumbar region and the lateral aspect of her breasts. On physical examination, the eruption consisted of small, erythematous, clustered papulovesicles along with some blisters and numerous crusted papules in a reticular arrangement (Figures 1 and 2). At the time of consultation, the patient was healthy and had a medical history relevant for 20 kg weight loss after 1 year of dieting and increased exercise. Urine and blood analysis (including blood count and renal and hepatic profile) found no abnormalities. Autoimmune study for antinuclear antibodies and antitransglutaminase antibodies was negative. Two punch biopsies from the lumbar region were obtained.

Reversed actinic damage in two children with xeroderma pigmentosum treated with topical imiquimod

E. Koukkou, A. Katsambas, C. Antoniou Department of Dermatology, Andreas Syggros Hospital, University of Athens, 5, I.Dragoumi street, 16121, Athens, Greece, Department of Endocrinology, “Elena Venizelou” Maternity Hospital, 2, Elenas Venizelou square, 11521, Athens, Greece, University of Athens, 18, Tetrapoleos street, 11527, Athens, Greece *Correspondence: C. Dessinioti. E-mail: cliodes@hotmail.com

Cutaneous Leishmania tropica in children: report of three imported cases successfully treated with liposomal amphotericin B

Cutaneous leishmaniasis (CL) is the most common form of leishmaniasis, being endemic in more than 90 countries around the world. The increasing number of international travelers to endemic areas has favored the expanding number of imported cases, making CL a mayor health issue.1,2 Herein, we report three immunocompetent children with multifocal CL caused by Leishmania tropica who received systemic therapy with liposomal amphotericin B (L-AmB). This article is protected by copyright. All rights reserved.

A Girl With Marfanoid Habitus and Distinctive Orolabial Lesions.

An adolescent girl with no relevant family history was referred to the dermatology pediatric unit for evaluation of multiple asymptomatic lesions on her tongue that had gradually developed since the first years of life. The patient had a marfanoid habitus, disproportion of limbs, and an enlarged face. Both lips were enlarged and felt nodular (Figure, A). Multiple pink-whitish and translucent nodules were observed on the lateral and anterior surface of the tongue (Figure, B). The rest of her physical examination did not reveal other cutaneous abnormalities, except for mild acne. Biopsy results from tongue tissue are shown in the Figure, C and D. Clinical appearance of patient’s lips A Multiple lingual nodes B