Nicole Kresge

Physical Proof of the Formation of Free Radicals: the Work of Isao Yamazaki

Identification, by Electron Paramagnetic Resonance Spectroscopy, of Free Radicals Generated from Substrates by Peroxidase (Yamazaki, I., Mason, H. S., and Piette, L. (1960) J. Biol. Chem. 235, 2444–2449) The Reduction of Cytochrome c by Enzyme-generated Ascorbic Free Radical (Yamazaki, I. (1962) J. Biol. Chem. 237, 224–229)

Editing Mischarged Amino Acids: the Work of Paul R. Schimmel

RNA Determinants for Translational Editing: Mischarging a Minihelix Substrate by a tRNA Synthetase (Nordin, B. E., and Schimmel, P. (1999) J. Biol. Chem. 274, 6835–6838) Structure-specific tRNA Determinants for Editing a Mischarged Amino Acid (Beebe, K., Merriman, E., and Schimmel, P. (2003) J. Biol. Chem. 278, 45056–45061)

Transition State Analogues of Purine Nucleoside Phosphorylase: the Work of Vernon L. Schramm

Transition State Analogue Inhibitors of Purine Nucleoside Phosphorylase from Plasmodium falciparum (Kicska, G. A., Tyler, P. C., Evans, G. B., Furneaux, R. H., Kim, K., and Schramm, V. L. (2002) J. Biol. Chem. 277, 3219–3225) Purine-less Death in Plasmodium falciparum Induced by Immucillin-H, a Transition State Analogue of Purine Nucleoside Phosphorylase (Kicska, G. A., Tyler, P. C., Evans, G. B., Furneaux, R. H., Schramm, V. L., and Kim, K. (2002) J. Biol. Chem. 277, 3226–3231) Achieving the Ultimate Physiological Goal in Transition State Analogue Inhibitors for Purine Nucleoside Phosphorylase (Lewandowicz, A., Tyler, P. C., Evans, G. B., Furneaux, R. H., and Schramm, V. L. (2003) J. Biol. Chem. 278, 31465–31468)

The Biochemical Disposal of Cholesterol: the Work of David Russell

Cloning, Structure, and Expression of the Mitochondrial Cytochrome P-450 Sterol 26-Hydroxylase, a Bile Acid Biosynthetic Enzyme (Andersson, S., Davis, D. L., Dahlbäck, H., Jörnvall, H., and Russell, D. W. (1989) J. Biol. Chem. 264, 8222–8229) Cloning and Regulation of Cholesterol 7α-Hydroxylase, the Rate-limiting Enzyme in Bile Acid Biosynthesis (Jelinek, D. F., Andersson, S., Slaughter, C. A., and Russell, D. W. (1990) J. Biol. Chem. 265, 8190–8197)