Nicole S. White
Neurocrine Biosciences
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Publication
Featured researches published by Nicole S. White.
Bioorganic & Medicinal Chemistry Letters | 2010
J. Robert Merritt; Ray Anthony James; Vidyadhar M. Paradkar; Chongwu Zhang; Ruiyan Liu; Jinqi Liu; Biji Jacob; Camelia Chiriac; Michael J. Ohlmeyer; Elizabeth Quadros; Pamela Wines; Jennifer Postelnek; Catherine M. Hicks; Weiqing Chen; Earl F. Kimble; Linda O’Brien; Nicole S. White; Hema Desai; Kenneth C. Appell; Maria L. Webb
A novel series of pyrrolidine heterocycles was prepared and found to show potent inhibitory activity of CCR1 binding and CCL3 mediated chemotaxis of a CCR1-expressing cell line. A potent, optimized triazole lead from this series was found to have acceptable pharmacokinetics and microsomal stability in rat and is suitable for further optimization and development.
Bioorganic & Medicinal Chemistry Letters | 2010
Brian F. Mcguinness; Andrew G. Cole; Guizhen Dong; Marc-Raleigh Brescia; Yuefei Shao; Ian R. Henderson; Laura L. Rokosz; Tara M. Stauffer; Neelima Mannava; Earl F. Kimble; Catherine M. Hicks; Nicole S. White; Pamela Wines; Elizabeth Quadros
A novel series of adenosine A(2A) receptor antagonists was identified by high-throughput screening of an encoded combinatorial compound collection. The initial hits were optimized for A(2A) binding affinity, A(1) selectivity, and in vitro microsomal stability generating orally available 2-aminoimidazo[4,5-b]pyridine-based A(2A) antagonist leads.
Archive | 2003
Joseph Pontillo; Dragan Marinkovic; Marion Lanier; Joe Ahn Tran; Melissa Arellano; Jessica Parker; Jodie Nelson; Chen Chen; Caroline W. Chen; Wanglong Jiang; Nicole S. White; Fabio C. Tucci
Bioorganic & Medicinal Chemistry Letters | 2005
Fabio C. Tucci; Nicole S. White; Stacy Markison; Margaret Joppa; Joe A. Tran; Beth A. Fleck; Ajay Madan; Brian Dyck; Jessica Parker; Joseph Pontillo; L. Melissa Arellano; Dragan Marinkovic; Wanlong Jiang; Caroline W. Chen; Kathleen Gogas; Val S. Goodfellow; John Saunders; Alan C. Foster; Chen Chen
Bioorganic & Medicinal Chemistry Letters | 2004
Joseph Pontillo; Joseph A. Tran; Melissa Arellano; Beth A. Fleck; Rajesh Huntley; Dragan Marinkovic; Marion Lanier; Jodie Nelson; Jessica Parker; John Saunders; Fabio C. Tucci; Wanlong Jiang; Caroline W. Chen; Nicole S. White; Alan C. Foster; Chen Chen
Bioorganic & Medicinal Chemistry Letters | 2006
Wanlong Jiang; Fabio C. Tucci; Caroline W. Chen; Melissa Arellano; Joe A. Tran; Nicole S. White; Dragan Marinkovic; Joseph Pontillo; Beth A. Fleck; Jenny Wen; John Saunders; Ajay Madan; Alan C. Foster; Chen Chen
Bioorganic & Medicinal Chemistry Letters | 2005
Joe A. Tran; Joseph Pontillo; Melissa Arellano; Nicole S. White; Beth A. Fleck; Dragan Marinkovic; Fabio C. Tucci; Marion Lanier; Jodie Nelson; John Saunders; Alan C. Foster; Chen Chen
Bioorganic & Medicinal Chemistry Letters | 2006
Caroline W. Chen; Joe A. Tran; Wanlong Jiang; Fabio C. Tucci; Melissa Arellano; Jenny Wen; Beth A. Fleck; Dragan Marinkovic; Nicole S. White; Joseph Pontillo; John Saunders; Ajay Madan; Alan C. Foster; Chen Chen
Bioorganic & Medicinal Chemistry | 2007
Joe A. Tran; Fabio C. Tucci; Wanlong Jiang; Dragan Marinkovic; Caroline W. Chen; Melissa Arellano; Stacy Markison; Beth A. Fleck; Jenny Wen; Nicole S. White; Joseph Pontillo; John Saunders; Daniel L. Marks; Sam R.J. Hoare; Ajay Madan; Alan C. Foster; Chen Chen
Bioorganic & Medicinal Chemistry Letters | 2005
Joseph Pontillo; Joe A. Tran; Nicole S. White; Melissa Arellano; Beth A. Fleck; Dragan Marinkovic; Fabio C. Tucci; John Saunders; Alan C. Foster; Chen Chen
