Nidhi Mishra

An efficient one-pot synthesis of N,N′-disubstituted ureas and carbamates from N-acylbenzotriazoles

A facile and high-yielding one-pot synthesis of carbamates and N,N′-disubstituted symmetrical ureas from N-acylbenzotriazoles has been devised. It is believed that, the intermediate acyl-azide undergo Curtius rearrangement and in different solvents gives different products i.e. carbamates in alcohols and N,N′-disubstituted symmetrical urea in THF.

Lewis-Acid-Mediated Benzotriazole Ring Cleavage (BtRC) Strategy for the Synthesis of 2-Aryl Benzoxazoles from N-Acylbenzotriazoles†

A Lewis-acid-mediated ring cleavage of acylbenzotriazoles (RCOBt) followed by cyclization to corresponding benzoxazoles was achieved in good to excellent yields. The reaction was found consistent with the milligram to gram scale.

Synthesis of novel macrocyclic crown ethers from D-glucose

GRAPHICAL ABSTRACT ABSTARCT A simple and efficient synthetic protocol for an easy access of carbohydrate-linked crown ethers from cheap and readily available D-glucose in good yields has been devised. The base-mediated cyclization of sugar-linked bis-iodo podands in CH3CN with amines, including ethylamine and furfurylamine afforded the novel chiral monoaza-15-crown-5-type macrocyclic crown ethers anellated to 3-O-benzyl-1,2-O-isopropylidene-α-D-glucofuranose and 3-O-benzyl-1,2-O-isopropylidene-α-D-allofuranose. The glucose-based crown ethers have been characterized by spectroscopy techniques including IR, 1H NMR, and 13C NMR.

Carbohydrate-Based Antidiabetic Agents From Nature

Diabetes mellitus is a chronic disease caused by inherited and/or acquired deficiency in production of insulin by the pancreas or by the ineffectiveness of the insulin produced. In this chapter, we describe on the management of type 2 diabetes with an aid of carbohydrate-containing molecules. The carbohydrate-based glucosidase inhibitors and sodium glucose cotransporter 2 inhibitors are the major active classes of compounds for the management of diabetes.Diabetes mellitus is a chronic disease caused by inherited and/or acquired deficiency in production of insulin by the pancreas or by the ineffectiveness of the insulin produced. In this chapter, we describe on the management of type 2 diabetes with an aid of carbohydrate-containing molecules. The carbohydrate-based glucosidase inhibitors and sodium glucose cotransporter 2 inhibitors are the major active classes of compounds for the management of diabetes.