Niels C. Klendshoj

Potent Typing Sera Produced by Treatment of Donors with Isolated Blood Group Specific Substances.

Conclusions The intravenous treatment of donors with purified A and B specific substances isolated from animal sources leads to a considerable increase in isoantibody titer. The substances used were highly purified and did not contain any demonstrable hog or horse protein. The administration of even small amounts is effective and results in the production of sera which are characterized by high titer, speed and specificity. The procedure described easily permits the production of large quantities of very potent typing serum.

Occurrence of Blood Group Specific Substances in Gastric Juice of Patients with Pernicious Anemia

Conclusion The gastric juice of patients suffering from pernicious anemia contained blood group specific substances at least in the same large amounts as normal gastric juice in spite of the fact that there was no free hydrochloric acid or pepsin present in the specimens. Eleven of the 12 patients were proved to belong to the so-called secretor group, while one was a non-secretor.