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Dive into the research topics where Nienke R. Biermasz is active.

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Featured researches published by Nienke R. Biermasz.


European Journal of Endocrinology | 2015

MECHANISMS IN ENDOCRINOLOGY: Cushing's syndrome causes irreversible effects on the human brain: a systematic review of structural and functional magnetic resonance imaging studies

Cornelie D Andela; Femke M van Haalen; Oskar Ragnarsson; Eleni Papakokkinou; Gudmundur Johannsson; Alicia Santos; Susan M. Webb; Nienke R. Biermasz; Nic J A van der Wee; Alberto M Pereira

BACKGROUNDnCushings syndrome (CS) is characterized by excessive exposure to cortisol, and is associated with both metabolic and behavioral abnormalities. Symptoms improve substantially after biochemical cure, but may persist during long-term remission. The causes for persistent morbidity are probably multi-factorial, including a profound effect of cortisol excess on the brain, a major target area for glucocorticoids.nnnOBJECTIVEnTo review publications evaluating brain characteristics in patients with CS using magnetic resonance imaging (MRI).nnnMETHODSnSystematic review of literature published in PubMed, Embase, Web of Knowledge, and Cochrane databases.nnnRESULTSnNineteen studies using MRI in patients with CS were selected, including studies in patients with active disease, patients in long-term remission, and longitudinal studies, covering a total of 339 unique patients. Patients with active disease showed smaller hippocampal volumes, enlarged ventricles, and cerebral atrophy as well as alterations in neurochemical concentrations and functional activity. After abrogation of cortisol excess, the reversibility of structural and neurochemical alterations was incomplete after long-term remission. MRI findings were related to clinical characteristics (i.e., cortisol levels, duration of exposure to hypercortisolism, current age, age at diagnosis, and triglyceride levels) and behavioral outcome (i.e., cognitive and emotional functioning, mood, and quality of life).nnnCONCLUSIONnPatients with active CS demonstrate brain abnormalities, which only partly recover after biochemical cure, because these still occur even after long-term remission. CS might be considered as a human model of nature that provides a keyhole perspective of the neurotoxic effects of exogenous glucocorticoids on the brain.


Clinical Medicine Insights: Therapeutics | 2009

Lanreotide Autogel® in the Treatment of Acromegaly:

Ferdinand Roelfsema; Nienke R. Biermasz; Alberto M. Pereira; Johannes A. Romijn

BackgroundIn acromegaly expert surgery is curative in only about 60% of patients. Postoperative radiation therapy is associated with a high incidence of hypopituitarism and its effect on GH production is slow, so that adjuvant medical treatment becomes of importance in the management of many patients.ObjectiveTo delineate the role of lanreotide Autogel® in the treatment of acromegaly.MethodsSearch of Medline, Embase and Web of Science databases for clinical lanreotide studies in acromegaly.ResultsThe weighted mean of serum GH normalization by Lanreotide Autogel®, based on 10 published clinical studies, was 58% in 370 patients. These patients were mostly switched from other somatostatin analogs. Serum IGF-I concentration normalized in 48% of these patients. Three small studies, with a total of 60 patients, compared the efficacy of octreotide LAR and that of lanreotide Autogel®. The highest dose of lanreotide appeared to be equivalent with 20 mg of octreotide LAR. Observed side effects were comparable with ...


Archive | 2015

Cushing's syndrome causes irreversible effects on the human brain: a systematic review of structural and functional magnetic resonance imaging studies

Cornelie D. Andela; Femke M van Haalen; Oskar Ragnarsson; Eleni Papakokkinou; Gudmundur Johannsson; Alicia Santos; Susan M Webb; Nienke R. Biermasz; Nic J A van der Wee; Alberto M. Pereira


Archive | 2014

Psychological morbidity and impaired quality of life in patients with

Jitske Tiemensma; Cornelie D. Andela; Ad A. Kaptein; Johannes A. Romijn; Nienke R. Biermasz; Alberto M. Pereira


Society for Endocrinology BES 2017 | 2017

Male IGSF1 deficient humans and mice exhibit somatotroph neurosecretory hyperfunction

Sjoerd D. Joustra; Ferdinand Roelfsema; Erik Endert; Trotsenburg ASPaul van; Eric Fliers; Harald Schneider; Robert P. Kosilek; Herman M. Kroon; John G Logan; Marc-Olivier Turgeon; Xiang Zhou; Chirine Toufaily; Olympia Koulouri; Mark Gurnell; JHDuncan Bassett; Graham R. Williams; Wilma Oostdijk; J.M. Wit; Alberto M. Pereira; Nienke R. Biermasz; Dan J Bernard; Nadia Schoenmakers


Archive | 2016

Mutations in TBL1X as a Novel Cause of Familial Central Hypothyroidism

Charlotte A Heinen; Monique Losekoot; Yu Sun; Peter J. Watson; Louise Fairall; Sjoerd D. Joustra; Nitash Zwaveling-Soonawala; Wilma Oostdijk; den Akker Erica van; Gijs W.E. Santen; Rijn Rick van; Wouter Dreschler; Olga V. Surovtseva; Nienke R. Biermasz; Raoul Hennekam; Jan Maarten Wit; John Schwabe; Anita Boelen; Eric Fliers; Trotsenburg Paul van


18th European Congress of Endocrinology | 2016

The partner perspective of the impact of pituitary disease: results from a focus group study

Cornelie D. Andela; Jitske Tiemensma; Adrian A. Kaptein; Margreet Scharloo; Alberto M. Pereira; Noëlle G. A. Kamminga; Nienke R. Biermasz


Archive | 2015

Total score or subscales in scoring the acromegaly quality of life

John M. Felt; Sarah Depaoli; Alberto M. Pereira; Nienke R. Biermasz; Jitske Tiemensma


17th European Congress of Endocrinology | 2015

Pituitary hormone secretion profiles in IGSF1 deficiency syndrome

Sjoerd D. Joustra; Ferdinand Roelfsema; Erik Endert; Bart E.P.B. Ballieux; Trotsenburg Paul van; Eric Fliers; Noortje Corssmit; Daniel J. Bernard; Wilma Oostdijk; J.M. Wit; Alberto M. Pereira; Nienke R. Biermasz


17th European Congress of Endocrinology | 2015

Mild cognitive deficits in patients on long-term, stable hydrocortisone replacement for primary adrenal insufficiency: a case-control study

Cornelie D. Andela; Jitske Tiemensma; Nienke R. Biermasz; Johannes A. Romijn; Alberto M. Pereira

Collaboration


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Alberto M. Pereira

Leiden University Medical Center

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Johannes A. Romijn

Leiden University Medical Center

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Ferdinand Roelfsema

Leiden University Medical Center

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Cornelie D. Andela

Leiden University Medical Center

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M. J. E. Wassenaar

Leiden University Medical Center

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Eric Fliers

University of Amsterdam

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Johanna H. Meijer

Leiden University Medical Center

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Nieke E. Kokshoorn

Leiden University Medical Center

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Sjoerd D. Joustra

Leiden University Medical Center

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