Nikichi Okumura

CORRELATION BETWEEN [U‐14C]GLUCOSE METABOLISM AND FUNCTION IN PERFUSED CAT BRAIN

Abstract— In brain perfusion experiments conducted with blood containing [U‐14C]glucose the relative specific activity (RSA) of blood glucose carbon incorporated in brain intermediate metabolites was measured. It was demonstrated that the so‐called metabolic pattern of Geiger is not constant, but it bears a close relation to the function of the brain. The results of the study may be summarized briefly as follows.

Effect of glucose on the function and metabolism of the perfused cat brain.

We studied the brain function, cerebral blood flow, oxygen and glucose consumption and amino acid liberation in the brain perfused with glucose‐containing blood and with glucose‐free blood in order to find out the effect of glucose on the function and metabolism of the brain. The perfusion of cat brain was performed principally according to the method of Ceiger and Magnes. The results were as follows:

NITROGEN METABOLISM OF THE BRAIN

A. In order to trace the nitrogen metabolism of the brain, ammonia and glutamine of the rat brain was measured by Conways microdiffusion method, and aminoacid by the paperchromatography. The following data are the return.

EFFECTS OF INTRACAROTID ADMINISTRATION OF β‐PHENYL‐γ‐AMINOBUTYRIC ACID ON THE PERFUSED CAT BRAIN

An investigation was carried out on the effects of intracarotid administration of β‐phenyl‐γ‐aminobutyric acid (β‐phenyl‐GABA) on the functions of a perfused cat brain. After injecting one ml, each of containing 1, 5, 10, 20, 25, or 35mg/ml of β‐phenyl‐GABA into the tubes perfusing the carotid arteries with standard artificial blood, the acute effects of the drug on EEG, cerebral blood flow, and oxygen consumption were observed.

TWO CASES OF ATYPICAL SPINAL PROGRESSIVE MUSCULAR ATROPHY (Lumbosacral Leg‐Thigh Type) A Clinicopathological Study with the Survey Of the Relevant Literature

The case histories and anatomic alterations of two patients with the lumbosacral leg‐thigh type of spinal progressive muscular atrophy are presented. The course of the diseese was very rapid, and the patients died of bulbar palsy in 7 months (first case) and 18 months (second case), respectively.