Nikita Saraswat

ROLE OF VARIOUS RISK FACTORS ASSOCIATED WITH CARDIOVASCULAR DISEASE S

Coronary Artery Disease (CAD) is the l eading cause of cardiovascular mortality world wide. Increasing rate of CAD mortality and projected rise in CAD mortality for 2020 in the developing world necessitates immediate prevention and control measures. Cardiovascular disease (CVD) is generally du e to reduced blood flow to the heart, brain or body caused by atheroma or thrombosis. It is increasingly common after the age of 60, but r are below the age of 30. Plaques (plates) of fatty atheroma build up in different arteries during adult life. These ca n eventually cause narrowing of the arteries, or trigger a local thrombosis (blood clot) which completely blocks the blood flow. Despite scientific evidence that evidence based drug therapy reduce mortality in patients with established CAD, these therapies continue to be underutilized in patients receiving conventional care. It is essential to identify and manage risk factors for coronary artery diseases and to implement unique and creative approaches to stimulate better adherence to practice guidelines, to improve the quality of care given to patients with CAD. Reduction of SBP, DBP, heart rate, and body fat%, total cholesterol, triglycerides and LDL after regular yogic practices is b eneficial for cardiac and hypertensive patients. Emphasis focusing on conv entional risk factors, lifestyle modifications, smoking cessation, reduction of central obesity through dietary modification and exercise, can be proved to be the key interventions for preventing CAD.

Sub Chronic and Sub-acute Toxicity Studies of Carbofuranon in Wistar Rat: Application to Neurobehavioral Evaluation

Carbofuran is a carbamate pesticide used in fields for promoting crop yield as it cuts down the expectancy of pests. It has been contaminating water in the nearby water sources which ultimately drained into water supply of towns and villages. It is a pollutant and is hazardous if consumed directly. We have conducted sub-acute and sub chronic toxicity studies on wistar rat for studying neurobehavioral effects using carbofuran as the key toxicant. The sub-acute studies were carried out daily dosing and experimenting toxicity studies on 7, 14, 21, 28 and 42 days of study and the sub chronic studies were carried out on giving repeated doses for 90 days and studying the toxic effects. The dose was administered in subsequent groups as 1 mg/kg b.wt, 2.5 mg/kg b.wt, 5 mg/kg b.wt dissolved in olive oil respectively. A control group of animal receiving saline was also established to compare the results and evaluate a clear outcome of the effects and toxicities. The neurobehavioral tests were performed using grip strength test, rota rod test, pain threshold, water consumption evaluation and weight evaluation were monitored during the course of experiment. So as to understand the behavior patterns exhibited by the Wistar rats during the course of experiment in comparison to the control group and the treated groups. The extent of damage was being evaluated by studying various doses of the pesticide and three groups were divided which were administered three different doses of Carbofuran drug at different concentrations.

A COMPARATIVE STUDY OF DRUG INTERACTION AND SIDE-EFFECT OF DRUG FOR TREATMENT OF DIABETES MELLITUS: A REVIEW

The objective of this review paper is to examine diabetes and via the modifying drugs treatment how to improve the patient condition and related risks. The review mentions the different types of comparative drugs which are useful for diagnosis or prevention of diabetes. Treatment modification can play a major role in the decreasing the diabetic patients. In India, a concerning 1-5% by population affected by diabetes or related difficulty. So there is required to use medications to cure the disease. If a patient suffers from diabetes used anti-diabetic drugs. These drugs are recommended for lowering the blood glucose levels. Metformin, Acarbose, thiazolidinedione etc. Most of the drugs are administered via orally so that called oral hypoglycemic or oral antihyperglycemic agents. Present days for treatment of diabetes available, different classes of anti-diabetic drugs and their choice depending on the patient diabetic type or the condition, age as well as other factors. Type 1 diabetes mainly caused by deficiency of insulin secretion the body. Researcher around the world focused on oral hypoglycemic agents and presents various types of comparative study to control the diabetes mellitus. The present review summarizes the comparative study of anti-diabetic drugs for the treatment of diabetes. This review article has shown a comparative study of drugs which are metformin more popular drug treatment of diabetes and they have the less side effect or higher efficacy, mention in the recently

A DEEP INSIGHT ON THE CAUSATIVE AGENTS SYMPTOMS AND CURE FOR SKIN CANCER: A REVIEW

The main objective of this review is to evaluate the current knowledge about the interrelation of skin and nutrient, particularly the influences of nutrients on cutaneous immune responses, the photo protective effects of nutrients and the therapeutic actions of nutrients in skin disorders. The review encompasses some medicinal plants used for the treatment of cancer disease. The plant sources of India likely provide effective anticancer agents. In this article, we have covered the information which is gathered from the plants used recently identified in the cancer treatment. The focused nutrients are carotenoids, vitamins, and polyunsaturated fatty acids.

A REVIEW ON IMPLICATIONS OF BIOLOGICAL RHYTHMS ON LONG-HAUL TRAVELLERS IN DIFFERENT TIME ZONES AND SEDENTARY LIFESTYLE: WORSENING OF DIABETES MELLITUS

Incidences of Diabetes mellitus (DM) gets worsen on frequent long-haul travel in different time zones and sedentary lifestyle. An extensive review of the published articles related to diabetes, the effect of lifestyle modification (exercise and diet) and travelling of diabetic people across different time zones were done and these were accessed from Pubmed-Medline, Web of Science, Cochrane Library, EMBASE, Lancet and Diabetes Care. The study done by different scientists were compared and interpreted for the worsening of cases of DM. For long-haul travel in different time zones, it was observed that, due to metabolic disturbances, serious consequences of DM were observed in flight, but that can be prevented if pre-advice are taken by the patients and strictly followed. The cumulative incidences of diabetes of 10 cases were compared and mean cumulative incidences of control group (following sedentary lifestyle) was 42.77% and of intervention group (following healthy diet and moderate physical activity) was 22.11% confirming that implementation of the healthy diet and exercise as regular physical activity caused the lowering of cumulative incidences of diabetes. According to the research conducted on frequent flyers and sedentary lifestyle, the hypothesis quoted by various scientists is that DM is a metabolic disorder which easily gets affected by the frequent changes in the metabolism leading to its high incidences. Thus, the concept of chronobiology comes into light that requires more research to correlate the disturbed biological rhythm (Circadian cycle) to the incidences and severity of DM condition (worsening or increased incidences of DM).

SUB CHRONIC AND SUB ACUTE TOXICITY STUDIES OF CARBOFURAN IN WISTAR RAT: APPLICATION TO NEUROBEHAVIOURAL EVALUATION

Carbofuran is a carbamate pesticide used in fields for promoting crop yield as it cuts down the expectancy of pests. It has been contaminating water in the nearby water sources which ultimately drained into water supply of towns and villages. It is a pollutant and is hazardous if consumed directly. We have conducted sub-acute and sub chronic toxicity studies on wistar rat for studying neurobehavioral effects using carbofuran as the key toxicant. The sub-acute studies were carried out daily dosing and experimenting toxicity studies on 7, 14, 21, 28 & 42 days of study and the sub chronic studies were carried out on giving repeated doses for 90 days and studying the toxic effects. The dose was administered in subsequent groups as 1 mg/kg b.wt, 2.5 mg/kg b.wt, 5 mg/kg b.wt dissolved in olive oil respectively. A control group of animal receiving saline was also established to compare the results and evaluate a clear outcome of the effects and toxicities. The neurobevioural tests were performed using grip strength test, rota rod test, pain threshold, water consumption evaluation and weight evaluation were monitored during the course of experiment. So as to understand the behavior patterns exhibited by the Wistar rats during the course of experiment in comparison to the control group and the treated groups. The extent of damage was being evaluated by studying various doses of the pesticide and three groups were divided which were administered three different doses of Carbofuran drug at different concentrations.

ANTI FERTILITY AND ANTI IMPLANTATION EFFECT OF GREEN TEA AQUEOUS EXTRACT ON FEMALE WISTAR RATS

Green Tea is obtained from the leaves of Camellia Sinensis plant. The green Tea comprises of caffeine as a major constituent. A lot has been listed out on the health benefits of drinking Green Tea. The plant belongs to family Theaceae. The aqueous extract (200mg/kg) was orally given to female wistar rats for fifteen days in treated group and saline solution to control group. We maintained five groups each of control and treated so as to get a clear picture and cumulative result of our research. The male rats were kept in each cage in ratio of 2:1 (Male: Female) from day 2-4 and then withdrawn. When the implantation and fertility studies were carried out a decrease in both the activities (Implantation and Fertility) was reported in case of treated group. The parameters of weight was also studied which reflected a increase in case of control group as compared to treated group. When the results were calculated and observed a decrease in implantation and fertility was shown by treated female rats which were on aqueous green tea dosing. The previous studies have been conducted on male wistar rats which proved a decrease in size of gonads thus helping us to aim at the female wistar rats in our research. The control groups showed a total of 16 implants as compared to the treated groups which collectively showed only 9 implants. This made our observation clear that both the fertility and implantation is affected under regular dosing of Green Tea aqueous extract.