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Niklas Heine

Boehringer Ingelheim

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Publication

Featured researches published by Niklas Heine.

Bioorganic & Medicinal Chemistry | 2018

Discovery of tetrahydroindazoles as a novel class of potent and in vivo efficacious gamma secretase modulators

Kai Gerlach; Scott Hobson; Christian Eickmeier; Ulrike Groß; Clemens Braun; Peter Sieger; Michel Garneau; Stefan Hoerer; Niklas Heine

The identification and optimization of a novel series of centrally efficacious gamma secretase modulators (GSMs) offering an alternative to the privileged aryl imidazole motif is described. Chiral bicyclic tetrahydroindazolyl amine substituted triazolopyridines were identified as structurally distinct novel series of GSMs. Representative compound BI-1408 ((R)-42) was demonstrated to be centrally efficacious in rats at a 30 mg/kg oral dose.

Archive | 2006

COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

Klaus Fuchs; Christian Eickmeier; Niklas Heine; Stefan Peters; Cornelia Dorner-Ciossek; Sandra Handschuh; Herbert Nar; Klaus Klinder

Archive | 2012

Fused dihydropyrans as gpr119 modulators for the treatment of diabetes, obesity and related diseases

Frank Himmelsbach; Matthias Eckhardt; Niklas Heine; Elke Langkopf; Bernd Nosse

Archive | 2009

1-heterocyclyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one derivatives and their use as pde9a modulators

Riccardo Giovannini; Cornelia Dorner-Ciossek; Christian Eickmeier; Dennis Fiegen; Thomas Fox; Klaus Fuchs; Niklas Heine; Holger Rosenbrock; Gerhard Schaenzle

Archive | 2008

1, 5-DIHYDRO-PYRAZOLO (3, 4-D) PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MODULATORS FOR THE TEATMENT OF CNS DISORDERS

Christian Eickmeier; Cornelia Dorner-Ciossek; Dennis Fiegen; Thomas Fox; Klaus Fuchs; Riccardo Giovannini; Niklas Heine; Martin Hendrix; Holger Rosenbrock; Gerhard Schaenzle

Archive | 2009

Substituted amino-quinazolinones, medicaments comprising said compound, their use and their method of manufacture

Klaus Fuchs; Niklas Heine; Christian Eickmeier; Sandra Handschuh; Cornelia Dorner-Ciossek; Stefan Hoerer

Archive | 2010

New compounds for the treatment of cns disorders

Niklas Heine; Cornelia Dorner-Ciossek; Christian Eickmeier; Dennis Fiegen; Thomas Fox; Klaus Fuchs; Riccardo Giovannini; Holger Rosenbrock; Gerhard Schaenzle; Lars Baerfacker

Archive | 2012

New compounds, pharmaceutical compositions and uses thereof

Gerald Juergen Roth; Martin Fleck; Niklas Heine; Joerg Kley; Thorsten Lehmann-Lintz; Heike Neubauer; Bernd Nosse

Archive | 2009

Pyrazolopyrimidines and their use for the treatment of cns disorders

Klaus Fuchs; Cornelia Dorner-Ciossek; Christian Eickmeier; Dennis Fiegen; Thomas Fox; Riccardo Giovannini; Niklas Heine; Martin Hendrix; Holger Rosenbrock; Gerhard Schaenzle

Archive | 2012

6-cycloalkyl-pyrazolopyrimidinones for the treatment of cns disorders

Niklas Heine; Christian Eickmeier; Marco Ferrara; Riccardo Giovannini; Holger Rosenbrock; Gerhard Schaenzle

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Christian Eickmeier

Boehringer Ingelheim

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Klaus Fuchs

Boehringer Ingelheim

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Cornelia Dorner-Ciossek

Boehringer Ingelheim

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Riccardo Giovannini

Boehringer Ingelheim

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Gerhard Schaenzle

Boehringer Ingelheim

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Holger Rosenbrock

Boehringer Ingelheim

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Dennis Fiegen

Boehringer Ingelheim

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Thomas Fox

Boehringer Ingelheim

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Sandra Handschuh

Boehringer Ingelheim

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Klaus Klinder

Boehringer Ingelheim

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