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Dive into the research topics where Niko Wasenius is active.

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Featured researches published by Niko Wasenius.


Annals of Medicine | 2013

Nordic walking decreased circulating chemerin and leptin concentrations in middle-aged men with impaired glucose regulation

Mika Venojärvi; Niko Wasenius; Sirpa Manderoos; Olli J. Heinonen; Miika Hernelahti; Harri Lindholm; Jukka Surakka; Jaana Lindström; Sirkka Aunola; Mustafa Atalay; Johan G. Eriksson

Abstract Background. Dysfunction of adipose tissue is one of the major factors leading to insulin resistance. Altered adipokine concentration is an early sign of adipose tissue dysfunction. The aim of this study was to assess the impact of exercise intervention on adipokine profile, glycemic control, and risk factors of the metabolic syndrome (MeS) in men with impaired glucose regulation (IGR). Methods. Overweight and obese men with IGR (n =144) aged 40–65 years were studied at baseline and at 12 weeks in a randomized controlled multicenter intervention study. BMI varied from 25.1 to 34.9. The subjects were randomized into one of three groups: 1) a control group (C; n =47), 2) a Nordic walking group (NW; n =48), or 3) a resistance training group (RT; n =49). Results. Leptin concentrations decreased in the NW group compared to both other groups. Both types of exercise intervention significantly decreased serum chemerin concentrations compared to the C group. In the NW group also body fat percentage, fatty liver index (FLI), and total and LDL cholesterol concentrations decreased compared to the RT group. Conclusions. Nordic walking intervention seems to decrease chemerin and leptin levels, and subjects in this intervention group achieved the most beneficial effects on components of MeS.


PLOS ONE | 2015

Physical Activity, Body Composition and Metabolic Syndrome in Young Adults

Minna K. Salonen; Niko Wasenius; Eero Kajantie; Aulikki Lano; Jari Lahti; Kati Heinonen; Katri Räikkönen; Johan G. Eriksson

Objective Low physical activity (PA) is a major risk factor for cardiovascular and metabolic disorders in all age groups. We measured intensity and volume of PA and examined the associations between PA and the metabolic syndrome (MS), its components and body composition among young Finnish adults. Research Design and Methods The study comprises 991 men and women born 1985-86, who participated in a clinical study during the years 2009-11 which included assessments of metabolism, body composition and PA. Objectively measured (SenseWear Armband) five-day PA data was available from 737 participants and was expressed in metabolic equivalents of task (MET). Results The prevalence of MS ranged between 8-10%. Higher total mean volume (MET-hours) or intensity (MET) were negatively associated with the risk of MS and separate components of MS, while the time spent at sedentary level of PA was positively associated with MS. Conclusions MS was prevalent in approximately every tenth of the young adults at the age of 24 years. Higher total mean intensity and volume rates as well as longer duration spent at moderate and vigorous PA level had a beneficial impact on the risk of MS. Longer time spent at the sedentary level of PA increased the risk of MS.


Scandinavian Journal of Medicine & Science in Sports | 2014

Unfavorable influence of structured exercise program on total leisure‐time physical activity

Niko Wasenius; Mika Venojärvi; Sirpa Manderoos; Jukka Surakka; Harri Lindholm; Olli J. Heinonen; Johan G. Eriksson; Esko Mälkiä; Sirkka Aunola

In randomized controlled trials (RCTs), with customized structured physical exercise activity (SPEA) interventions, the dose of leisure‐time physical activity (LTPA) should exceed the LTPA dose of the nonexercising control (C) group. This increase is required to substantiate health improvements achievable by exercise. We aimed to compare the dose of SPEA, LTPA, and total LTPA (SPEA + LTPA) between a randomized Nordic walking (NW) group, a power‐type resistance training (RT) group, and a C group during a 12‐week exercise intervention in obese middle‐aged men (n = 144) with impaired glucose regulation. The dose of physical activity was measured with diaries using metabolic equivalents. No significant difference (P > 0.107) between the groups was found in volume of total LTPA. The volume of LTPA was, however, significantly higher (P < 0.050) in the C group than in the NW group, but not compared with the RT group. These results indicate that structured exercise does not automatically increase the total LTPA level, possibly, as a result of compensation of LTPA with structured exercise or spontaneous activation of the C group. Thus, the dose of total LTPA and the possible changes in spontaneous LTPA should be taken into account when implementing a RCT design with exercise intervention.


WOS | 2014

Unfavorable influence of structured exercise program on total leisure- time physical activity

Niko Wasenius; Mika Venojärvi; Sirpa Manderoos; Jukka Surakka; Harri Lindholm; Olli J. Heinonen; Johan G. Eriksson; Esko Mälkiä; Sirkka Aunola

In randomized controlled trials (RCTs), with customized structured physical exercise activity (SPEA) interventions, the dose of leisure‐time physical activity (LTPA) should exceed the LTPA dose of the nonexercising control (C) group. This increase is required to substantiate health improvements achievable by exercise. We aimed to compare the dose of SPEA, LTPA, and total LTPA (SPEA + LTPA) between a randomized Nordic walking (NW) group, a power‐type resistance training (RT) group, and a C group during a 12‐week exercise intervention in obese middle‐aged men (n = 144) with impaired glucose regulation. The dose of physical activity was measured with diaries using metabolic equivalents. No significant difference (P > 0.107) between the groups was found in volume of total LTPA. The volume of LTPA was, however, significantly higher (P < 0.050) in the C group than in the NW group, but not compared with the RT group. These results indicate that structured exercise does not automatically increase the total LTPA level, possibly, as a result of compensation of LTPA with structured exercise or spontaneous activation of the C group. Thus, the dose of total LTPA and the possible changes in spontaneous LTPA should be taken into account when implementing a RCT design with exercise intervention.


Journal of Hypertension | 2015

Former male elite athletes and risk of hypertension in later life

Merja K. Laine; Urho M. Kujala; Johan G. Eriksson; Niko Wasenius; Jaakko Kaprio; Heli M. Bäckmand; Markku Peltonen; Olli J. Heinonen; Antti Jula; Seppo Sarna

Objective: The aim of this study was to assess whether a former career as an elite athlete protects from hypertension in later life. We hypothesized that vigorous physical activity during young adulthood protects against hypertension later in life. Methods: The study population (n = 3440) consists of 2037 former male elite athletes and 1403 matched controls. Of those, 599 (392 former athletes, 207 controls) participated in a clinical study in 2008. The athletes were divided into three groups: endurance, mixed and power sports. Assessment of hypertension was based on athletes’ entitlement to reimbursable antihypertensive medication from the Finnish Social Insurance Institution; among the clinical study participants, this was also based on self-reported current use of antihypertensive drugs or measured hypertension. The current volume of leisure-time physical activity (LTPA) was determined by questionnaires. Results: Among the participants, the former athletes had lower age-adjusted prevalence of hypertension than the controls [odds ratio (OR) 0.69, 95% confidence interval (CI) 0.49–0.98] and the endurance athletes had the lowest OR (OR 0.43, 95% CI 0.23–0.80). OR for the prevalence of hypertension decreased (OR 0.90, 95% CI 0.84–0.96 per 10 metabolic equivalent hours/week) when there was an increase in the volume of LTPA. The former athletes without blood pressure-lowering medication had significantly lower SBP than the controls [139.2 mmHg (SD 18.7) vs. 144.2 mmHg (SD 19.5)] (P = 0.027). Conclusion: A former career as an elite athlete seems to be associated with a lower prevalence of hypertension in later life. The volume of current LTPA was inversely related to prevalence of hypertension.


Scandinavian Journal of Medicine & Science in Sports | 2017

Mobility and muscle strength in male former elite endurance and power athletes aged 66−91 years

Sirpa Manderoos; Niko Wasenius; Merja K. Laine; Urho M. Kujala; Esko Mälkiä; Jaakko Kaprio; Seppo Sarna; Heli M. Bäckmand; Jyrki Kettunen; Olli J. Heinonen; Antti Jula; Sirkka Aunola; Johan G. Eriksson

The aim of this cross‐sectional study was to compare mobility and muscle strength in male former elite endurance and power athletes aged 66−91 years (n = 150; 50 men in both former elite athlete groups and in their control group). Agility, dynamic balance, walking speed, chair stand, self‐rated balance confidence (ABC‐scale), jumping height, and handgrip strength were assessed. Former elite power athletes had better agility performance time than the controls (age‐ and body mass index, BMI‐adjusted mean difference −3.6 s; 95% CI −6.3, −0.8). Adjustment for current leisure time physical activity (LTPA) and prevalence of diseases made this difference non‐significant (P = 0.214). The subjects in the power sports group jumped higher than the men in the control group (age‐ and BMI‐adjusted mean differences for vertical squat jump, VSJ 4.4 cm; 95% CI 2.0, 6.8; for countermovement jump, CMJ 4.0 cm; 95% CI 1.7, 6.4). Taking current LTPA and chronic diseases for adjusting process did not improve explorative power of the model. No significant differences between the groups were found in the performances evaluating dynamic balance, walking speed, chair stand, ABC‐scale, or handgrip strength. In conclusion, power athletes among the aged former elite sportsmen had greater explosive force production in their lower extremities than the men in the control group.


PLOS ONE | 2017

Maternal gestational weight gain and objectively measured physical activity among offspring

Niko Wasenius; Kimberly P. Grattan; Alysha Harvey; Nick Barrowman; Gary S. Goldfield; Kristi B. Adamo

Objective Animal studies have suggested that maternal weight-related factors during pregnancy can program offspring physical activity in a sex-dependent manner. However, there is limited evidence in humans. The purpose of this study was to investigate the association between maternal gestational weight gain (GWG) and offspring total physical activity (TPA) level and to determine whether these associations are moderated by sex of offspring or maternal pre-pregnancy weight status. Method We studied 56 boys (mean age = 3.7 years, standard deviation (SD) 0.5) and 57 girls (mean age = 3.5±0.5 years) enrolled in licensed childcare centers. TPA was objectively measured using Actical® accelerometers. Information on pre-pregnancy body mass index (BMI), GWG, and other maternal factors were collected with a maternal health questionnaire. Associations between GWG, as a continuous variable or categorically (inadequate, adequate, and excessive), and offspring TPA were analysed using linear mixed models to take into account the intraclass correlation between the clusters (childcare centers). Models were adjusted for gestational age, accelerometer weartime, socioeconomic status, and pre-pregnancy BMI status. Results We found a significant sex interaction (P-value = 0.009). In boys, greater GWG was associated with decreased offspring TPA (β = -3.2 counts⋅1000−1/d, 95% confidence intervals (CI) = -6.4–0.02, P-value = 0.049). In girls born to mothers categorized as overweight or obese, the association between the GWG and TPA followed an inverted U-shape curve (β for GWG squared = -0.1 counts⋅1000−1/d, 95% CI = (-0.2 –-0.04), P-value = 0.005). In contrast, a U-shaped curve was found in girls born to mothers classified as lean (pre-pregnancy BMI<25 kg/m2) (β for GWG squared = 0.7 counts⋅1000−1/d, 95% CI = 0.2–1.2, P-value = 0.011). In boys, TPA in offspring was higher among women with inadequate GWG compared to adequate GWG (P-value = 0.0137), whereas no significant differences were found in girls (P-value = 0.107). Conclusion Maternal GWG can be an important biological marker of offspring TPA. These findings support the sex-dependent early developmental programming influence of GWG on TPA.


Age and Ageing | 2016

Intellectual ability in young adulthood as an antecedent of physical functioning in older age

Taina Poranen-Clark; Mikaela B. von Bonsdorff; Timo Törmäkangas; Jari Lahti; Niko Wasenius; Katri Räikkönen; Clive Osmond; Minna K. Salonen; Taina Rantanen; Eero Kajantie; Johan G. Eriksson

OBJECTIVES low cognitive ability is associated with subsequent functional disability. Whether this association extends across adult life has been little studied. The aim of this study was to examine the association between intellectual ability in young adulthood and physical functioning during a 10-year follow-up in older age. METHODS three hundred and sixty persons of the Helsinki Birth Cohort Study (HBCS) male members, born between 1934 and 1944 and residing in Finland in 1971, took part in The Finnish Defence Forces Basic Intellectual Ability Test during the first 2 weeks of their military service training between 1952 and 1972. Their physical functioning was assessed twice using the Short Form 36 (SF-36) questionnaire at average ages of 61 and 71 years. A longitudinal path model linking Intellectual Ability Test score to the physical functioning assessments was used to explore the effect of intellectual ability in young adulthood on physical functioning in older age. RESULTS after adjustments for age at measurement, childhood socioeconomic status and adult BMI (kg/m(2)), better intellectual ability total and arithmetic and verbal reasoning subtest scores in young adulthood predicted better physical functioning at age 61 years (P values <0.021). Intellectual ability total and arithmetic and verbal reasoning subtest scores in young adulthood had indirect effects on physical functioning at age 71 years (P values <0.022) through better physical functioning at age 61 years. Adjustment for main chronic diseases did not change the results materially. CONCLUSION better early-life intellectual ability helps in maintaining better physical functioning in older age.


PLOS ONE | 2018

Correction: Maternal gestational weight gain and objectively measured physical activity among offspring

Niko Wasenius; Kimberly P. Grattan; Alysha Harvey; Nick Barrowman; Gary S. Goldfield; Kristi B. Adamo

[This corrects the article DOI: 10.1371/journal.pone.0180249.].


European Journal of Sport Science | 2018

Plasma irisin is increased following 12 weeks of Nordic walking and associates with glucose homoeostasis in overweight/obese men with impaired glucose regulation

Ayhan Korkmaz; Mika Venojärvi; Niko Wasenius; Sirpa Manderoos; Keith C. DeRuisseau; Eva-Karin Gidlund; Olli J. Heinonen; Harri Lindholm; Sirkka Aunola; Johan G. Eriksson; Mustafa Atalay

Abstract Irisin is a myokine that is thought to be secreted in response to exercise that may help to prevent obesity and maintain normal glucose metabolism. In this study we investigated the associations between irisin and glucose homeostasis in middle-aged, overweight and obese men (n =  144) with impaired glucose regulation, and the impact of exercise training on these relationships. The participants underwent 12 weeks of resistance or aerobic (Nordic walking) exercise training three times per week, 60 minutes per session. Venous blood (n = 105) and skeletal muscle samples (n = 45) were obtained at baseline and post-intervention. Compared to controls, Nordic walking, but not resistance training, increased irisin levels in plasma (9.6 ± 4.2%, P = 0.014; 8.7 ±  4.9%, P = 0.087; respectively) compared to controls. When considering all subjects, baseline irisin correlated positively with atherogenic index of plasma (r = 0.244, P = 0.013) and 2-hour insulin levels (r = 0.214, P = 0.028), and negatively with age (r = −0.262, P = 0.007), adiponectin (r = −0.240, P = 0.014) and McAuley index (r = −0.259, P = 0.008). Training-induced FNDC5 mRNA changes were negatively correlated with HbA1c (r = −0.527, P = 0.030) in the resistance training group and with chemerin in the Nordic walking group (r = −0.615, P = 0.033). In conclusion, 12-weeks of Nordic walking was more effective than resistance training in elevating plasma irisin, in middle-aged men with impaired glucose tolerance. Thus, the change in irisin in response to exercise training varied by the type of exercise but showed limited association with improvements in glucose homeostasis.

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Sirkka Aunola

National Institute for Health and Welfare

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Sirpa Manderoos

National Institute for Health and Welfare

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Mika Venojärvi

University of Eastern Finland

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Esko Mälkiä

University of Jyväskylä

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Minna K. Salonen

National Institute for Health and Welfare

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Jukka Surakka

Arcada University of Applied Sciences

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Eero Kajantie

National Institute for Health and Welfare

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