Nils-Ove Månsson

Self-rated health as a predictor of disability pension and death--a prospective study of middle-aged men

Objective: Self-rated health (SRH) is increasingly attracting attention as a predictor of morbidity and mortality while its relation to impaired function has been given less momentum. The aim of this study was to assess the relation between SRH and the risk of being awarded a disability pension and premature death. Methods : Five birth-year cohorts of middle-aged men were invited to a screening programme and were followed for approximately 11 years. Of the 718 (12%) men with a disability pension granted during follow-up, 46% had perceived their health as perfect on inclusion. The corresponding figure for the remaining 5,082 men was 77%. Results: The crude relative risk (RR) of disability pension for men with SRH less than perfect was 3.7 (3.2-4.2). After adjustment for premorbidity/medication, the RR declined to 3.3 (2.8-3.8). The crude RR of death associated with SRH less than perfect was 1.6 (1.3-2.0), unchanged after adjustment. Conclusion: The results showed that SRH is a strong and independent predictor of disability and, to a lesser degree, of mortality.

The relation between self-rated health, socioeconomic status, body mass index and disability pension among middle-aged men

The aim of this study was to assess the relations between self-rated health (SRH), socioeconomic status (SES), body mass index (BMI) and disability pension. Five birth-year cohorts of middle-aged male residents in Malmö, Sweden, were invited and 5313 with complete data constituted the cohort in this study. Each subject was followed for approximately 11 years. Of all subjects, 73% perceived their health as perfect and among obese men and blue collar workers, the corresponding figures were 67 and 68% respectively. The adjusted odds ratios for SRH less than perfect was 1.3 (CI: 1.1–1.7) for obese subjects and 1.7 (CI: 1.5–1.9) for blue collar workers. The interaction between low SES and obesity was estimated to 11% which was not statistically significant. The adjusted relative risks (RR) of disability pension was 3.3 for subjects with SRH less than perfect, 2.2 for blue collar workers and 2.0 for obese subjects, all statistically significant and only marginally less than the crude RR. Thus, SRH among middle-aged men was associated with obesity as well as low SES, but no evidence of synergism between obesity and low SES in relation to SRH was found. Furthermore, poor SRH in particular, but also low SES and obesity, independently predicted disability pension.

Dizziness among patients with whiplash-associated disorder: a randomized controlled trial.

OBJECTIVE To investigate whether vestibular rehabilitation for patients with whiplash-associated disorder and dizziness had any effect on balance measures and self-perceived handicap. DESIGN Randomized, controlled trial. SUBJECTS Twenty-nine patients, 20 women and 9 men, age range 22-76 years. METHODS The patients were randomized to an intervention group or a control group. The intervention comprised vestibular rehabilitation. All patients were assessed at baseline, after 6 weeks and after 3 months with 4 different balance measures and the Dizziness Handicap Inventory. RESULTS After 6 weeks, the intervention group showed statistically significant improvements compared with the control group in the following measures: standing on one leg eyes open (p=0.02), blindfolded tandem stance (p=0.045), Dizziness Handicap Inventory total score (p=0.047), Dizziness Handicap Inventory functional score (p=0.005) and in Dizziness Handicap Inventory physical score (p=0.033). After 3 months, the intervention group showed statistically significant improvements compared with the control group in the following measures: standing on one leg eyes open (p=0.000), tandem stance (p=0.033) and Dizziness Handicap Inventory physical score (p=0.04). CONCLUSION Vestibular rehabilitation for patients with whiplash-associated disorder can decrease self-perceived handicap and increase postural control.

Self-rated health in relation to age and gender: influence on mortality risk in the Malmö Preventive Project.

Aims: A study was undertaken to examine whether poor self-rated health (SRH) can independently predict all-cause mortality during 22-year follow-up in middle-aged men and women. Subjects and methods: Data are derived from a population-based study in Malmö, Sweden. This included baseline laboratory testing and a self-administered questionnaire. The question on global SRH was answered by 15,590 men (mean age 46.4 years) and 10,089 women (49.4 years). Social background characteristics (occupation, marital status) were based on data from national censuses. Mortality was retrieved from national registers. Results: At screening 4,261 (27.3%) men and 3,085 (30.6%) women reported poor SRH. Among subjects rating their SRH as low, 1,022 (24.0%) men and 228 (7.4%) women died during follow-up. Corresponding figures for subjects rating their SRH as high were 1801 (15.9%) men and 376 (5.4%) women. An analysis of survival in subjects reporting poor SRH revealed an age-adjusted hazard risk ratio (HR, 95%CI) for men HR 1.5 (1.4—1.7), and for women HR 1.4 (1.2—1.6). The corresponding HR after adjusting for possible social confounders was for men HR 1.3 (1.1—1.4), and women HR 1.1 (0.9—1.4). When additional adjustment was made for biological risk factors the association for men was still significant, HR 1.2 (1.1—1.3). Conclusion: Poor SRH predicts increased long-term mortality in healthy, middle-aged subjects. For men the association is independent of both social background and selected biological variables. The adjustment for biological variables can be questioned as they might represent mediating mechanisms in a possible causal chain of events.

Benign Paroxysmal Positional Vertigo among Elderly Patients in Primary Health Care

Background:Dizziness influences well-being in old age, and benign paroxysmal positional vertigo (BPPV) is a common cause. The condition is diagnosed using the Hallpike maneuver and treated by the particle-repositioning maneuver or habituation exercises. Objective:To identify patients with BPPV among a variety of diagnoses represented by the ICD-10 diagnosis R42 in people 65 aged years and older who visited primary health care because of vertigo and dizziness. Methods:Searches were performed in the computerized medical records of 6 different health care centers over the period of 1 year for the ICD-10 diagnosis R42 and the age group 65 years and older. Letters were sent to the patients identified with an invitation for assessment and physical examination by a physiotherapist. Thirty-eight patients responded to the letter and were included in the study. All patients were assessed by physical examination including the Hallpike maneuver. Results: The study group included 13 men and 25 women, 65–94 (median 83) years of age. After physical examination, 15 patients were found to have BPPV (confidence interval 24–55%). Conclusion:In this study, 2 of 5 of the patients with ICD-10 diagnosis R42 (dizziness and giddiness) had BPPV. BPPV is probably an underestimated cause of dizziness/vertigo among elderly patients in primary health care.

Alcohol consumption and disability pension among middle-aged men

PURPOSE To analyze the relation between alcohol consumption and the risk of disability pension among middle-aged men. METHODS In the mid-seventies, complete birth-year cohorts of middle-aged male residents in Malmö, Sweden, were invited to participate in a general health survey. The 3751 men with complete data who constituted the cohort in this study were followed for 11 years. Alcohol consumption was estimated from the scores obtained from a test designed to identify subjects with alcohol related problems. RESULTS Of the 498 men granted disability pension during follow-up, 48 stated to be teetotalers. The cumulative incidence of disability pension among teetotalers was 19%, whereas, it was 12% and 16%, respectively, among men with low and high alcohol consumption. The adjusted relative risk (RR) for acquiring a disability pension (using the group with low alcohol consumption as reference) was 1.8 among abstainers and 1.3 among men with high alcohol consumption. CONCLUSIONS Alcohol overconsumption, as well as teetotalism, showed a positive relation to disability pension, and a moderate alcohol intake was found to be beneficial with respect to the risk of future disability pension.

Risk factors for respiratory tract infections in children aged 2-5 years

Objective - To study risk factors for respiratory tract infections (RTIs) in children aged 2-5 years. Design - A questionnaire was used to chart the number of visits to doctors and the number of antibiotics courses because of RTIs during a 1-year period. The risk factors studied were age, sex, birth weight, breastfeeding, atopy, siblings, smoking and childcare. Setting - The catchment area of Oxie health centre in southern Sweden. Subjects - 190 pre-school children. Main outcome measures - Number of visits to doctors and number of antibiotics courses. Results - The risk of having to consult a doctor, as well as the risk of receiving treatment with antibiotics, because of RTIs was greater among children at daycare centres than among children who were mostly at home (adjusted OR 2.78 (95% CI 1.34?5.78) and 2.73 (1.38?5.43), respectively). Conclusion - Attending a daycare centre is the most important risk factor for RTIs in children aged 2?5 years.OBJECTIVE To study risk factors for respiratory tract infections (RTIs) in children aged 2-5 years. DESIGN A questionnaire was used to chart the number of visits to doctors and the number of antibiotics courses because of RTIs during a 1-year period. The risk factors studied were age, sex, birth weight, breastfeeding, atopy, siblings, smoking and childcare. SETTING The catchment area of Oxie health centre in southern Sweden. SUBJECTS 190 pre-school children. MAIN OUTCOME MEASURES Number of visits to doctors and number of antibiotics courses. RESULTS The risk of having to consult a doctor, as well as the risk of receiving treatment with antibiotics, because of RTIs was greater among children at daycare centres than among children who were mostly at home (adjusted OR 2.78 (95% CI 1.34-5.78) and 2.73 (1.38-5.43), respectively). CONCLUSION Attending a daycare centre is the most important risk factor for RTIs in children aged 2-5 years.

Mortality in elderly men with low psychosocial coping resources using anxiolytic-hypnotic drugs

Objective: Insufficient coping with stress may lead to increased susceptibility for disease and death. Use of anxiolytic-hypnotic drugs has been suggested as a coping strategy, and some opinions have proposed their use as preventive medication. The aim of this study was to estimate if use of anxiolytic-hypnotic drugs counters the increased mortality observed in individuals lacking other coping strategies such as emotional support and social participation. Methods: A population based cohort study with 10-year (1982/83 - 1993) survival analysis was performed in 491 men born in 1914, living in the Swedish city of Malmö. Results: Compared with men with a high level of psychosocial coping resources who did not use anxiolytic-hypnotic drugs, men with a low level of psychosocial coping resources had a higher risk of death irrespective whether they used anxiolytic-hypnotic drugs, RR=1.7 (95% CI 1.1 - 2.6) or not (RR=1.8 (95%: 1.3 - 2.5). Conclusion: Anxiolytic-hypnotic drugs do not seem to counter increased mortality in elderly men with low psychosocial coping resources.

Can sulphonylurea addition to lifestyle changes help to delay diabetes development in subjects with impaired fasting glucose? The Nepi ANtidiabetes StudY (NANSY)

The Nepi ANtidiabetes StudY (NANSY) is a 5‐year randomized, double‐blind, placebo‐controlled trial in Swedish primary care, examining whether the development of type 2 diabetes (T2D) and retinopathy (separately reported) would be delayed in 40‐ to 70‐year‐old subjects with impaired fasting glucose (IFG) who, in addition to lifestyle changes, were treated with either placebo or low‐dosage sulphonylurea (SU) (1‐mg glimepiride; Amaryl®). Of 274 subjects (163 men, 111 women), 138 were allocated to placebo (46.0% men, 56.8% women) and 136 to glimepiride (54.0% men, 43.2% women). The primary endpoint was conversion to diabetes. Average follow‐up time was 3.71 years; 96 subjects converted to diabetes, 55 allocated to placebo and 41 to glimepiride (absolute difference 9.8%; p = 0.072). In conclusion, the study failed to support the notion that low‐dose SU added to lifestyle changes in IFG subjects would help to delay the conversion to diabetes.

Neighborhood social participation, use of anxiolytic-hypnotic drugs, and women's propensity for disability pension: a multilevel analysis

Aims: The increasing number of people on disability pension in Sweden is of concern for Swedish policy-makers, and there is a need for a better understanding of the mechanisms behind disability pension. We investigated (i) whether women living in the same neighborhood have a similar propensity for disability pension that relates to neighborhood social participation, and (ii) whether there is an association between anxiolytic-hypnotic drug (AHD) use and disability pension in women that is modified by the neighborhood context. Methods: We used multilevel logistic regression with 12,156 women aged 45 to 64 (first level) residing in 95 neighborhoods (second level) in the city of Malmö (250,000 inhabitants), Sweden, who participated in the Malmö Diet and Cancer Study (1991—96). Results: Both AHD use (OR=2.09, 95% CI 1.65, 2.65) and neighborhood rate of low social participation (OR=11.85, 95% CI 5.09, 27.58) were associated with higher propensity for disability pension. The interval odds ratio indicated that the influence of neighborhood social participation was large compared with the unexplained variance between the neighborhoods. The association between AHD use and disability pension was not modified by the neighborhood context. The median odds ratio was 1.44 after adjusting for individual characteristics and 1.27 after the additional adjusting for neighborhood social participation. Conclusions: Women living in the same neighborhood appear to have a similar propensity for disability pension, beyond individual characteristics, and this contextual effect seems largely explained by neighborhood social participation. In addition, AHD use might increase the propensity for disability pension in women.