Nina Berova

Comprehensive Chiroptical Spectroscopy: Applications in Stereochemical Analysis of Synthetic Compounds, Natural Products, and Biomolecules

This book provides an introduction to the important methods of chiroptical spectroscopy in general, and circular dichroism (CD) in particular, which are increasingly important in all areas of chemistry, biochemistry, and structural biology. The book can be used as a text for undergraduate and graduate students and as a reference for researchers in academia and industry. Experimental methods and instrumentation are described with topics ranging from the most widely used methods (electronic and vibrational CD) to frontier areas such as nonlinear spectroscopy and photoelectron CD, as well as the theory of chiroptical methods and techniques for simulating chiroptical properties. Applications of chiroptical spectroscopy to problems in organic stereochemistry, inorganic stereochemistry, and biochemistry and structural biology are also discussed, and each chapter is written by one or more leading authorities with extensive experience in the field.

Circular dichroic studies of 2-amino-2-deoxy-galactopyranosides - conformations of the 2-(N-acetyl-p-bromobenzamido) group

Abstract The CD spectra of methyl 2-amino-2-deoxy-D-galactopyranoside mono- N -acylates (acetyl or p -bromobenzoyl) resemble those of the corresponding O -acylates and can be accounted for by the additivity rule. However, the CD of pyranosides containing the N -acetyl- p -bromobenzamido imide group (NAcBz) are far more complex than those of mono- N -acylates and their O -counterparts, and furthermore, the solvent- and temperature-dependent changes differ for the α- and β-anomers. These differences can be accounted for by the different conformations of the 2-NAcBz group.