Nishma Patel
University College London
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Publication
Featured researches published by Nishma Patel.
British Journal of Psychiatry | 2014
Gill Livingston; Lynsey Kelly; Elanor Lewis-Holmes; Gianluca Baio; Stephen Morris; Nishma Patel; Rumana Z. Omar; Cornelius Katona; Claudia Cooper
BACKGROUND Agitation in dementia is common, persistent and distressing and can lead to care breakdown. Medication is often ineffective and harmful. AIMS To systematically review randomised controlled trial evidence regarding non-pharmacological interventions. Method We reviewed 33 studies fitting predetermined criteria, assessed their validity and calculated standardised effect sizes (SES). RESULTS Person-centred care, communication skills training and adapted dementia care mapping decreased symptomatic and severe agitation in care homes immediately (SES range 0.3-1.8) and for up to 6 months afterwards (SES range 0.2-2.2). Activities and music therapy by protocol (SES range 0.5-0.6) decreased overall agitation and sensory intervention decreased clinically significant agitation immediately. Aromatherapy and light therapy did not demonstrate efficacy. CONCLUSIONS There are evidence-based strategies for care homes. Future interventions should focus on consistent and long-term implementation through staff training. Further research is needed for people living in their own homes.
BMJ | 2012
Elizabeth Schroeder; Stavros Petrou; Nishma Patel; Jennifer Hollowell; D. Puddicombe; Maggie Redshaw; Peter Brocklehurst
Objectives To estimate the cost effectiveness of alternative planned places of birth. Design Economic evaluation with individual level data from the Birthplace national prospective cohort study. Setting 142 of 147 trusts providing home birth services, 53 of 56 freestanding midwifery units, 43 of 51 alongside midwifery units, and a random sample of 36 of 180 obstetric units, stratified by unit size and geographical region, in England, over varying periods of time within the study period 1 April 2008 to 30 April 2010. Participants 64 538 women at low risk of complications before the onset of labour. Interventions Planned birth in four alternative settings: at home, in freestanding midwifery units, in alongside midwifery units, and in obstetric units. Main outcome measures Incremental cost per adverse perinatal outcome avoided, adverse maternal morbidity avoided, and additional normal birth. The non-parametric bootstrap method was used to generate net monetary benefits and construct cost effectiveness acceptability curves at alternative thresholds for cost effectiveness. Results The total unadjusted mean costs were £1066, £1435, £1461, and £1631 for births planned at home, in freestanding midwifery units, in alongside midwifery units, and in obstetric units, respectively (equivalent to about €1274,
Archives of Disease in Childhood-fetal and Neonatal Edition | 2013
Neil Marlow; Tim P. Morris; Peter Brocklehurst; Robert Carr; Frances Cowan; Nishma Patel; Stavros Petrou; Margaret Redshaw; Neena Modi; Caroline J Doré
1701; €1715,
Value in Health | 2010
Dean A. Regier; Stavros Petrou; Jane Henderson; Oya Eddama; Nishma Patel; Brenda Strohm; Peter Brocklehurst; A. David Edwards; Denis Azzopardi
2290; €1747,
BMJ Open | 2015
Stephen Morris; Nishma Patel; Gianluca Baio; Lynsey Kelly; Elanor Lewis-Holmes; Rumana Z. Omar; Cornelius Katona; Claudia Cooper; Gill Livingston
2332; and €1950,
International Journal of Stroke | 2016
Stephen Morris; Nishma Patel; Joanna Dobson; Roland L Featherstone; Toby Richards; Ramon Luengo-Fernandez; Peter M. Rothwell; Martin M. Brown
2603). Overall, and for multiparous women, planned birth at home generated the greatest mean net benefit with a 100% probability of being the optimal setting across all thresholds of cost effectiveness when perinatal outcomes were considered. There was, however, an increased incidence of adverse perinatal outcome associated with planned birth at home in nulliparous low risk women, resulting in the probability of it being the most cost effective option at a cost effectiveness threshold of £20 000 declining to 0.63. With regards to maternal outcomes in nulliparous and multiparous women, planned birth at home generated the greatest mean net benefit with a 100% probability of being the optimal setting across all thresholds of cost effectiveness. Conclusions For multiparous women at low risk of complications, planned birth at home was the most cost effective option. For nulliparous low risk women, planned birth at home is still likely to be the most cost effective option but is associated with an increase in adverse perinatal outcomes.
British Journal of General Practice | 2014
Martin Marshall; James Mountford; Kirsten Gamet; Gulsen Gungor; Conor Burke; Robyn Hudson; Steve Morris; Nishma Patel; Phil Koczan; Rob Meaker; Cyril Chantler; Christopher Michael Roberts
Objective The authors performed a randomised trial in very preterm small-for-gestational age (SGA) babies to determine if prophylaxis with granulocyte-macrophage colony-stimulating factor (GM-CSF) improves outcomes (the PROGRAMS trial). Despite increased neutrophil counts following GM-CSF, the authors reported no significant difference in neonatal sepsis-free survival. Patients and methods 280 babies born <31 weeks of gestation and SGA were entered into the trial. Outcome was determined at 2 years to determine neurodevelopmental and general health outcomes, including economic costs. Results The authors found no significant differences in health outcomes or health and social care costs between the trial groups. In the GM-CSF arm, 87 of 134 (65%) babies survived to 2 years without severe disability compared with 87 of 131 (66%) controls (RR: 1·0, 95% CI 0·8 to 1·2). Marginally, more children receiving GM-CSF were reported to have cough (RR 1·7, 95% CI 1·1 to 2·6) and had signs of chronic respiratory disease (Harrisons sulcus; RR 2·0, 95% CI 1·0 to 3·9) though this was not reflected in bronchodilator use or need for hospitalisation for respiratory disease. Overall, the rate of neurologic abnormality (7%–9%) was similar but mean overall developmental scores were lower than expected for gestational age. Conclusions The administration of GM-CSF to very preterm SGA babies is not associated with improved or more adverse outcomes at 2 years of age. The apparent excess of developmental impairment in the entire PROGRAMS cohort, without corresponding increase in neurological abnormality, may represent diffuse brain injury attributable to intrauterine growth restriction.
BMJ Open | 2018
Nishma Patel; Rebecca J. Beeken; Baptiste Leurent; Rumana Z. Omar; Irwin Nazareth; Stephen Morris
OBJECTIVE To estimate the cost-effectiveness (CE) of total body hypothermia plus intensive care versus intensive care alone to treat neonatal encephalopathy. METHODS Decision analytic modeling was used to synthesize mortality and morbidity data from three randomized controlled trials, the Total Body Hypothermia for Neonatal Encephalopathy Trial (TOBY), National Institute of Child Health and Human Development (NICHD), and CoolCap trials. Cost data inputs were informed by TOBY, the sole source of prospectively collected resource utilization data for encephalopathic infants. CE was expressed in terms of incremental cost per disability-free life year (DFLY) gained. Probabilistic sensitivity analysis was performed to generate CE acceptability curves (CEACs). RESULTS Cooling led to a cost increase of £3787 (95% confidence interval [CI]: -2516, 12,360) (€5115; 95% CI: -3398-16,694; US
The Lancet | 2016
Nishma Patel; Bridget R Ferns; Eleni Nastouli; Zisis Kozlakidis; Paul Kellam; Stephen Morris
5344; 95% CI: -3598, 26,356; using 2006 Organisation for Economic Co-operation and Development (OECD) purchasing power parities) and a DFLY gain of 0.19 (95%CI: 0.07-0.31) over the first 18 months after birth. The incremental cost per DFLY gained was £19,931 (€26,920; US
Health Technology Assessment | 2014
Gill Livingston; Lynsey Kelly; Elanor Lewis-Holmes; Gianluca Baio; Stephen E. Morris; Nishma Patel; Rumana Z. Omar; Cornelius Katona; Claudia Cooper
28,124). The baseline CEAC showed that if decision-makers are willing to pay £30,000 for an additional DFLY, there is a 69% probability that cooling is cost-effective. The probability of CE exceeded 99% at this threshold when the throughput of infants was increased to reflect the national incidence of neonatal encephalopathy or when the time horizon of the economic evaluation was extended to 18 years after birth. CONCLUSIONS The probability that cooling is a cost-effective treatment for neonatal encephalopathy is finely balanced over the first 18 months after birth but increases substantially when national incidence data or an extended time horizon are considered.