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Dive into the research topics where Nisse V. Clark is active.

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Featured researches published by Nisse V. Clark.


Jsls-journal of The Society of Laparoendoscopic Surgeons | 2017

Impact of a Fellowship-Trained Minimally Invasive Gynecologic Surgeon on Patient Outcomes

Nisse V. Clark; Harneet Gujral; Kelly N. Wright

Background and Objectives: As the performance of minimally invasive hysterectomy has increased in the United States, the need to apply outcomes measures has also increased. This study was conducted to determine the impact of a fellowship-trained minimally invasive gynecologic surgery (MIGS) specialist on patient outcomes after laparoscopic hysterectomy (LH) in a gynecology department. Methods: This is a retrospective review of 218 patients who underwent a laparoscopic hysterectomy for benign indications at a suburban academic-affiliated tertiary care hospital with a broad patient base from 2010 to 2014. Results: A total of 218 women underwent conventional laparoscopic hysterectomy by 10 members of a gynecology department: 96 women (44%) by a MIGS specialist and 122 women (56%) by a group of general gynecologists. Operative time was less (119 vs 148 min; P < .001), and patients were more likely to be discharged on the same day (90.6% vs 66.4%; P < .001) for the MIGS specialist compared to other surgeons. More patients of the MIGS specialist had undergone prior laparotomies (42.7% vs 17.2%; P = < .001) and had a greater uterine weight (392 vs 224 g; P < .001). Although the difference was not statistically significant, conversion to laparotomy (0 vs 2 cases; P = .505) and postoperative infection (6 vs 16 cases; P = .095) were lower for the MIGS specialist. Total billing charges were also lower for the MIGS specialist (


Journal of Minimally Invasive Gynecology | 2017

Opioid Prescription and Patient Use After Gynecologic Procedures: A Survey of Patients and Providers

Kendall C. Griffith; Nisse V. Clark; Andrea Zuckerman; Tanaz R. Ferzandi; Kelly N. Wright

9,920 vs


Journal of Minimally Invasive Gynecology | 2017

Tissue Extraction Techniques During Laparoscopic Uterine Surgery

Nisse V. Clark; Sarah L. Cohen

11,406; P < .001). Conclusion: A fellowship-trained MIGS specialist performed laparoscopic hysterectomy in less time on more difficult surgical patients, with a shorter length of stay and lower costs, and no difference in complications compared to other providers in a gynecology department.


Journal of Minimally Invasive Gynecology | 2017

Case Report: Three-Dimensional Printed Model for Deep Infiltrating Endometriosis

Mobolaji O. Ajao; Nisse V. Clark; Tatiana Kelil; Sarah L. Cohen; J.I. Einarsson

STUDY OBJECTIVE To describe opioid distribution and patient use after gynecologic procedures. DESIGN Survey study (Canadian Task Force classification III). SETTING An urban academic tertiary care hospital. SUBJECTS Ninety-six gynecologists in the Boston area, and 147 patients who underwent a benign hysterectomy between January 2015 and April 2016. INTERVENTIONS Survey study of physicians and patients composed of 2 parts: (1) a physician survey on opioid prescribing practices after gynecologic procedures and (2) a patient survey on opioid consumption after hysterectomy. Physicians were contacted via e-mail to participate in an online survey. Eligible patients were contacted via telephone and asked to participate in a telephone survey. MEASUREMENTS AND MAIN RESULTS Fifty-one physicians responded to an online survey and prescribed a mean of 27.1 tablets (range, 5-30) of oxycodone (5 mg) or hydromorphone (2 mg) after abdominal hysterectomy (AH), a mean of 22.6 tablets (range, 5-30) after laparoscopic hysterectomy (LH), and a mean of 16.8 tablets (range 5-30) after vaginal hysterectomy (VH). Physicians prescribed more opioids for AH compared with LH, with a mean difference of 4.5 tablets (standard deviation, 4.7; p < .01), and AH compared with VH, with a mean difference of 6.8 tablets (standard deviation, 5.8; p < .01), which were both statistically significant. In addition, 40.0% of physicians prescribe opioids after a hysteroscopy and 19.2% after a dilation and curettage. Fifty-six patients participated in the telephone survey: 64.6% of patients used less than half of the opioids prescribed and 16.1% used none. For AH, patients reported being prescribed a mean of 25.7 tablets and using a mean of 8.7 tablets (range, 0-60; 33.9% used). For LH or VH, patients reported being prescribed a mean of 24.2 tablets and using a mean of 10.0 tablets (range, 0-30; 41.4% used). Opioid consumption was not significantly different for AH compared with LH or VH (p = .613 for AH to LH, p = .279 for AH to VH). CONCLUSIONS With respect to the physician survey, we conclude there is a wide range of opioid prescription practices and patient opioid consumption after gynecologic surgery. The patient survey revealed that physicians prescribe fewer opioid tablets after a minimally invasive approach to hysterectomy versus open hysterectomy. However, most patients use less than half of prescribed opioids, and a fraction did not use any opioids at all.


Journal of Minimally Invasive Gynecology | 2018

Prospective Evaluation of Manual Morcellation Techniques: Minilaparotomy versus Vaginal Approach

Sarah L. Cohen; Nisse V. Clark; Mobolaji O. Ajao; Douglas N. Brown; Antonio R. Gargiulo; Xiangmei Gu; J.I. Einarsson

Morcellation allows minimally invasive approaches to surgery even in the presence of large uteri or myomas. Recent restrictions in the use of power morcellation, as well as concerns regarding the potential for morcellation to disseminate malignant tissue, have initiated investigation and innovation to find safer methods. This review examines current techniques for tissue extraction during uterine surgery, with a focus on contained power morcellation and contained manual morcellation via mini-laparotomy or colpotomy. Videos are included to demonstrate these methods.


Journal of Minimally Invasive Gynecology | 2018

Incisional Outcomes of Umbilical Versus Suprapubic Minilaparotomy for Tissue Extraction: a Retrospective Cohort Study

Kendall C. Griffith; Nisse V. Clark; A.A. Mushinski; Xiangmei Gu; Mobolaji O. Ajao; D.N. Brown; J.I. Einarsson; Sarah L. Cohen

The combination of a thorough physical examination and imaging with either magnetic resonance imaging (MRI) or pelvic ultrasound are important in the preoperative planning for deep infiltrating endometriosis (DIE). A 2-dimensional (2D) rendering of the pathology by imaging does not always accurately represent intraoperative findings. The detailed topographical relationship and extent of surrounding tissue invasion can be better appreciated by 3-dimensional (3D) modeling. A 49-year-old patient with history of endometriosis and persistent pain underwent preoperative MRI that showed features consistent with DIE endometriosis. Surgery was performed, and the findings were documented. A 3D printed model of the DIE was generated from the MRI and retrospectively compared with intraoperative findings. The 3D model demonstrated both the laterality and spatial relationship of the endometriotic nodule to the posterior uterine wall and rectum. Three-dimensional printing of DIE may be a beneficial adjunct to 2D imaging and can identify further structural relationships to support surgical planning.


Journal of Minimally Invasive Gynecology | 2017

Review of Sterilization Techniques and Clinical Updates

Nisse V. Clark; Scott P. Endicott; Elisa M. Jorgensen; Hye-Chun Hur; Ernest G. Lockrow; Mary Kern; Candice Jones-Cox; Susan G. Dunlow; J.I. Einarsson; Sarah L. Cohen

STUDY OBJECTIVE To compare the number of days required to return to daily activities after laparoscopic hysterectomy with 2 tissue extraction methods: manual morcellation via colpotomy or minilaparotomy. Secondary outcomes were additional measures of patient recovery, perioperative outcomes, containment bag integrity, and tissue spillage. DESIGN Multicenter prospective cohort study and follow-up survey (Canadian Task Force classification II-2). SETTING Two tertiary care academic centers in northeastern United States. PATIENTS Seventy women undergoing laparoscopic hysterectomy with anticipated need for manual morcellation. INTERVENTIONS Tissue extraction by either contained minilaparotomy or contained vaginal extraction method, along with patient-completed recovery diary. MEASUREMENTS AND MAIN RESULTS Recovery diaries were returned by 85.3% of participants. There were no significant differences found in terms of average pain at 1, 2, or 3 weeks after surgery or in time to return to normal activities. Patients in both groups used narcotic pain medication for an average of 3 days. After adjusting for patient body mass index, history of prior surgery, uterine weight, and surgeon, there were no differences found for blood loss, operative time, length of stay, or incidence of any intra- or postoperative complication between groups. All patients had benign findings on final pathology. More cases in the vaginal contained extraction group were noted to have bag leakage on postprocedure testing (13 [40.6%] vs 3 [8.3%] tears in vaginal and minilaparotomy groups, respectively; p = .003). CONCLUSION Regarding route of tissue extraction, contained minilaparotomy and contained vaginal extraction methods are associated with similar patient outcomes and recovery characteristics.


Journal of Minimally Invasive Gynecology | 2017

Independent Roll-Down Ring for Contained Tissue Extraction

Nisse V. Clark; J.I. Einarsson

STUDY OBJECTIVE To compare outcomes following umbilical minilaparotomy and suprapubic minilaparotomy for tissue extraction. DESIGN CLASSIFICATION Retrospective cohort study (Canadian Task Force classification II-2). SETTING Two large academic medical centers. PATIENTS Women who underwent a minilaparotomy for tissue extraction following a laparoscopic hysterectomy or myomectomy between 2014 and 2016. INTERVENTIONS Umbilical or suprapubic minilaparotomy for tissue extraction. MEASUREMENTS AND MAIN RESULTS A total of 374 women underwent laparoscopic hysterectomy or myomectomy with minilaparotomy, including 289 (77.3%) with an umbilical minilaparotomy and 85 (22.7%) with a suprapubic minilaparotomy. The 2 groups were similar in terms of age, body mass index, parity, surgical history, procedure type, surgical approach, and surgical indication. The size of the minilaparotomy incision and the specimen weight were significantly smaller in the umbilical minilaparotomy group (mean, 3.3 ± 0.8 cm vs 4.2 ± 0.6 cm [p < .001] and 472.6 ± 357.1 g vs 683.0 ± 475.7 g [p < .001], respectively). Two women in the suprapubic minilaparotomy group sustained a bladder injury during creation of the incision. There were no other complications related to the minilaparotomy in either group. Postoperative outcomes related to the minilaparotomy incision were compiled using the medical record and a follow-up survey. Of the 374 women in this cohort, 163 responded to a detailed survey about their minilaparotomy incision (response rate, 43.5%). With regard to the minilaparotomy, 52.7% of women reported incisional symptoms; 25.9% had increased pain at the incision, 8.3% had an incisional infection, and 2.7% reported an incisional hernia. There was no significant between-group difference in incisional outcomes; however nearly 3 times as many women in the umbilical minilaparotomy group reported concerns about incisional hernia (3.1% vs 1.2%; p = .833). These findings were maintained in a multivariable logistic regression analysis. No patient or procedure characteristics were significantly associated with the development of hernia. CONCLUSION There were no significant difference in incisional symptoms, pain, or infection following umbilical minilaparotomy vs a suprapubic minilaparotomy for tissue extraction. Although not statistically significant, the rate of incisional hernia was higher at the umbilical site compared with the suprapubic site.


CRSLS: MIS Case Reports from SLS | 2017

Parasitic Leiomyomas Following Laparoscopic Myomectomy

Nisse V. Clark; Mateo G. Leon; Colleen M. Feltmate; Sarah L. Cohen

Sterilization is the most common form of contraception used worldwide and is highly effective in preventing unintended pregnancy. Each of the available sterilization methods has unique advantages and disadvantages that influence the choice of approach for each individual patient. Salpingectomy for sterilization has become more popular in recent years, with mounting evidence suggesting a protective effect against ovarian cancers originating in the fallopian tube. At the same time, Essure hysteroscopic sterilization has come under scrutiny because of increasing reports of possible adverse effects associated with its use. Here we review clinical updates in sterilization techniques, with a focus on salpingectomy and Essure hysteroscopic sterilization.


Acta Obstetricia et Gynecologica Scandinavica | 2017

The menstrual cycle and blood loss during laparoscopic myomectomy

Nisse V. Clark; Karen C. Wang; Jessica Opoku-Anane; C.I. Hill-Lydecker; Allison F. Vitonis; J.I. Einarsson; Sarah L. Cohen

An independent roll-down ring can be used to improve exposure during contained tissue extraction. We have used this technique in approximately 50 cases to date with good success. In this article we briefly describe our technique.

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J.I. Einarsson

Brigham and Women's Hospital

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Sarah L. Cohen

Brigham and Women's Hospital

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Mobolaji O. Ajao

Brigham and Women's Hospital

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A.A. Mushinski

Brigham and Women's Hospital

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Xiangmei Gu

Brigham and Women's Hospital

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Harneet Gujral

Brigham and Women's Hospital

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