Nizar Moayeri

Extraneural versus Intraneural Stimulation Thresholds during Ultrasound-guided Supraclavicular Block

Background:A stimulation current of no more than 0.5mA is regarded as safe in avoiding nerve injury and delivering adequate stimulus to provoke a motor response. However, there is no consistent level of stimulating threshold that reliably indicates intraneural placement of the needle. The authors determined the minimally required stimulation threshold to elicit a motor response outside and inside the most superficial part of the brachial plexus during high-resolution, ultrasound-guided, supraclavicular block. Methods:After institutional review board approval, ultrasound-guided, supraclavicular block was performed on 55 patients. Patients with neurologic dysfunction were excluded. Criteria for extraneural and intraneural stimulation were defined and assessed by independent experts. To determine success rate and any residual neurologic deficit, qualitative sensory and motor examinations were performed before and after block placement. At 6 month follow-up, the patients were examined for any neurologic deficit. Results:Thirty-nine patients met all set stimulation criteria. Median ± SD (interquartile range) minimum stimulation threshold outside was 0.60 ± 0.37 mA (0.40, 1.0) and inside 0.30 ± 0.19 mA (0.20, 0.40). The difference of 0.30 mA was statistically significant (P < 0.0001). Stimulation currents of 0.2 mA or less were not observed outside the trunk in any patient. Significantly higher thresholds were observed in diabetic patients. Success rate was 100% after 20 min. Thirty-four patients had normal sensory and motor examination at 6 months. Five patients were lost to follow-up. Conclusion:Within the limitations of this study and the use of ultrasound, a stimulation current of 0.2 mA or less is reliable to detect intraneural placement of the needle. Furthermore, stimulation currents of more than 0.2 and no more than 0.5 mA could not rule out intraneural position.

Quantitative Architecture of the Brachial Plexus and Surrounding Compartments, and Their Possible Significance for Plexus Blocks

Background:Nerve injury after regional anesthesia of the brachial plexus (BP) is a relatively rare and feared complication that is partly attributed to intraneural injection. However, recent studies have shown that intraneural injection does not invariably cause neural injury, which may be related to the architecture within the epineurium. A quantitative study of the neural components and the compartment outside BP was made. Methods:From four frozen shoulders, high-resolution images of sagittal cross-sections with an interval of 0.078 mm were obtained using a cryomicrotome to maintain a relatively undisturbed anatomy. From this data set, cross-sections perpendicular to the axis of the BP were reconstructed in the interscalene, supraclavicular, midinfraclavicular, and subcoracoid regions. Surface areas of both intraepineurial and connective tissue compartments outside the BP were delineated and measured. Results:The nonneural tissue (stroma and connective tissue) inside and outside the BP increased from proximal to distal, being significant between interscalene/supraclavicular and midinfraclavicular/subcoracoid regions (P < 0.001 for tissue inside BP, P < 0.02 for tissue outside BP). The median amount of neural tissue remained approximately the same in the four measured regions (41.1 ± 6.3 mm2; range, 30–60 mm2). The ratio of neural to nonneural tissue inside the epineurium increased from 1:1 in the interscalene/supraclavicular to 1:2 in the midinfraclavicular/subcoracoid regions. Conclusion:Marked differences in neural architecture and size of surrounding adipose tissue compartments are demonstrated between proximal and distal parts of the brachial plexus. These differences may explain why some injections within the epineurium do not result in neural injury and affect onset times of BP blocks.

Differences in Quantitative Architecture of Sciatic Nerve May Explain Differences in Potential Vulnerability to Nerve Injury, Onset Time, and Minimum Effective Anesthetic Volume

Background:In sciatic nerve (SN) blocks, differences are seen in risk of nerve damage, minimum effective anesthetic volume, and onset time. This might be related to differences in the ratio neural:nonneural tissue within the nerve. For the brachial plexus, a higher proximal ratio may explain the higher risk for neural injury in proximal nerve blocks. A similar trend in risk is reported for SN; however, equivalent quantitative data are lacking. The authors aimed to determine the ratio neural:nonneural tissue within SN in situ in the upper leg. Methods:From five consecutive cadavers, the region between the sacrum and distal femur condyle was harvested and frozen. Using a cryomicrotome, consecutive transversal sections (interval, 78 &mgr;m) were obtained and photographed. Reconstructions of SN were made strictly perpendicular to its long axis in the midgluteal, subgluteal, midfemoral, and popliteal regions. The epineurial area and all neural fascicles were delineated and measured. The nonneural tissue compartment inside and outside SN was also delineated and measured. Results:The amount of neural tissue inside the epineurium decreased significantly toward distal (midfemoral/popliteal region) (P < 0.001). The relative percentage of neural tissue decreased from midgluteal (67 ± 7%), to subgluteal (57 ± 9%), to midfemoral (46 ± 10%), to popliteal (46 ± 11%). Outside the SN, the adipose compartment increased significantly toward distal (P < 0.007). Conclusion:In SN, the ratio neural:nonneural tissue changes significantly from 2:1 (midgluteal and subgluteal) to 1:1 (midfemoral and popliteal). This suggests a higher vulnerability for neurologic sequelae in proximal SN, and may explain differences observed in minimum effective anesthetic volume and onset time between proximal and distal SN blocks.

Correlation between ultrasound imaging, cross-sectional anatomy, and histology of the brachial plexus: a review.

The anatomy of the brachial plexus is complex. To facilitate the understanding of the ultrasound appearance of the brachial plexus, we present a review of important anatomic considerations. A detailed correlation of reconstructed, cross-sectional gross anatomy and histology with ultrasound sonoanatomy is provided.

Different Approaches to Ultrasound-guided Thoracic Paravertebral Block An Illustrated Review

Given the fast development and increasing clinical relevance of ultrasound guidance for thoracic paravertebral blockade, this review article strives (1) to provide comprehensive information on thoracic paravertebral space anatomy, tailored to the needs of a regional anesthesia practitioner, (2) to interpret ultrasound images of the thoracic paravertebral space using cross-sectional anatomical images that are matched in location and plane, and (3) to briefly describe and discuss different ultrasound-guided approaches to thoracic paravertebral blockade. To illustrate the pertinent anatomy, high-resolution photographs of anatomical cross-sections are used. By using voxel anatomy, it is possible to visualize the needle pathway of different approaches in the same human specimen. This offers a unique presentation of this complex anatomical region and is inherently more realistic than anatomical drawings.

Early ultrasonographic detection of low-volume intraneural injection

BACKGROUND Intraneural injection of local anaesthetic agents carries a risk of neurological complications. Early detection of intraneural needle-tip position is very important in the initial phase of injection. Ultrasound (US) characteristics for real-time detection of intraneural injections have been described, but only for relatively large volumes (5-40 ml). This study assesses the reliability of various US criteria to detect early low volume (0.5 ml) intraneural injections. Intraneural deposition of an injected dye was confirmed by cryomicrotomy. METHODS In nine unembalmed human cadavers, 0.5 ml methylene blue was injected intraneurally into the supraclavicular brachial plexus and subgluteal sciatic nerve on both sides. The sites of injection were subsequently removed en bloc. Consecutive cryomicrotomy cross-sections with a 50 µm interval were obtained to assess intraneural presence of the injectate. Two independent experts separately reviewed US video clips of the injections and scored each US criterion. RESULTS Of the 36 injections, cryomicrotome cross-sections showed intraneural staining in 33 and extraneural staining in three. The best US criterion was expansion of the nerve cross-sectional surface area together with a change in echogenicity. It was observed in 35 injections, including two false positives. There was one true negative. Test precision was 94% [95% confidence interval (CI), 87-100%]. The mean increase in surface area was 8.7% (95% CI, 5.6-11.9). CONCLUSIONS Reliable detection of early low-volume intraneural injection using US is possible using expansion of the cross-sectional surface area of the nerve together with a change in echogenicity as markers.

Intraneural or Extraneural Diagnostic Accuracy of Ultrasound Assessment for Localizing Low-Volume Injection

Background and Objectives When one is performing ultrasound-guided peripheral nerve blocks, it is common to inject a small amount of fluid to confirm correct placement of the needle tip. If an intraneural needle tip position is detected, the needle can then be repositioned to prevent injection of a large amount of local anesthetic into the nerve. However, it is unknown if anesthesiologists can accurately discriminate intraneural and extraneural injection of small volumes. Therefore, this study was conducted to determine the diagnostic accuracy of ultrasound assessment using a criterion standard and to compare experts and novices in ultrasound-guided regional anesthesia. Methods A total of 32 ultrasound-guided infragluteal sciatic nerve blocks were performed on 21 cadaver legs. The injections were targeted to be intraneural (n = 18) or extraneural (n = 14), and 0.5 mL of methylene blue 1% was injected. Cryosections of the nerve and surrounding tissue were assessed by a blinded investigator as “extraneural” or “intraneural.” Ultrasound video clips of the injections were reviewed by 10 blinded observers (5 experts, 5 novices) independently who scored each injection as either “intraneural,” “extraneural,” or “undetermined.” Results The mean sensitivity of experts and novices was measured to be 0.84 (0.80–0.88) and 0.65 (0.60–0.71), respectively (P = 0.006), whereas mean specificity was 0.97 (0.94–0.98) and 0.98 (0.96–0.99) (P = 0.53). Conclusions Discrimination of intraneural or extraneural needle tip position based on an injection of 0.5mL is possible, but even experts missed 1 of 6 intraneural injections. In novices, the sensitivity of assessment was significantly lower, highlighting the need for focused education.

Soft tissue landmark for ultrasound identification of the sciatic nerve in the infragluteal region: the tendon of the long head of the biceps femoris muscle

Background and objectives: The sciatic nerve block represents one of the more difficult ultrasound‐guided nerve blocks. Easy and reliable internal ultrasound landmarks would be helpful for localization of the sciatic nerve. Earlier, during ultrasound‐guided posterior approaches to the infragluteal sciatic nerve, the authors recognized a hyperechoic structure at the medial border of the long head of biceps femoris muscle (BFL). The present study was performed to determine whether this is a potential internal landmark to identify the infragluteal sciatic nerve.

Vertical Infraclavicular Brachial Plexus Block: Needle Redirection After Elicitation of Elbow Flexion

Background: In vertical infraclavicular brachial plexus block, success depends on distal flexion or extension response. Initially, elbow flexion (lateral cord) is generally observed. However, specific knowledge about how to reach the medial or posterior cord is lacking. We investigated the mid-infraclavicular area in undisturbed anatomy and tested the findings in a clinical setting. Methods: Along a length of 35 mm around the mid-infraclavicular point, cryomicrotomy sections of 5 shoulders from cadavers were used todetermine the topography of the cords in relation to one another and the axillary artery. Based on the findings, the anesthesiologists were instructed on how to elicit a distal motor response after an initial elbow flexion response in single-shot, Doppler-aided, vertical infraclavicular block in a series of 50 consecutive patients. Results: In the mid-infraclavicular area, the lateral cord always lies anterior to either the posterior or the medial cord and cranial to the axillary artery; the posterior cord was always cranial to the medial cord; and both cords were always located dorsal to the artery. In the clinical study, in 98% of the included patients, finger flexion or finger and/or wrist extension was elicited as predicted. The overall success rate was 92%. No vascular or lung puncture occurred. Conclusions: In the clinical study, in 98% of cases, the final stimulation response of posterior or medial cord was found as predicted by the findings of the anatomic study. Once elbow flexion is elicited, a further (ie, deeper) advancement of the needle will result in the proper distal motor response.