Noah R. Calhoun

Necrotizing sialometaplasia in a patient with Buerger's disease and Raynaud's phenomenon

This report describes a case of necrotizing sialometaplasia (NS) in a patient diagnosed as having Buergers disease with secondary Raynauds phenomenon. The danger of misdiagnosing NS as a malignant lesion is emphasized. Possible causal relationships between the patients medical condition and the lesion are discussed.

Papillary cystadenoma of the upper lip: Report of a case☆

Abstract It was thought that the lesion in the foregoing case may have had its origin from ducts of minor salivary glands or possibly from remnant apocrine gland structures.

Oral manifestation of mycosis fungoides

Abstract A case of mycosis fungoides with severe involvement of the oral mucous membranes has been reported.

Monomorphic adenoma of the buccal mucosa

Abstract Monomorphic adenoma is a benign tumor that may originate in either major or minor salivary glands. 2,3 Those that arise in minor glands occur most frequently in the upper lip, have no strong predilection for either sex, and have occured exclusively in whites. The usual clinical appearance is an asymptomatic, freely movable lump or mass; ulceration of the overlying mucosa is rare. The case presented is noteworthy because it occurred in the buccal mucosa of an American black and it became ulcerated prior to the patients seeking professional care.

The effects of zinc on ectopic bone formation.

The effect of dietary zinc deficiency was studies in ectopic bone formation subsequent to Achilles tenotomy and also following the implantation of demineralized bone matrix in the muscle of rats. Three experiments were performed. The first was designed to investigate the relationship between zinc and calcium concentration during the formation of ectopic bone in rats fed a commercial laboratory ration, the second concerned the effects of dietary zinc deficiency on ectopic bone formation, and the third studies the subsequent effects of dietary zinc repletion on ectopic bone formation. The results indicated that, with the commercial ration, zinc increased concomitantly with calcium during ectopic bone formation in rats. Dietary zinc deficiency caused a retardation of ectopic bone formation and a significant reduction of in situ zinc and calcium concentration. Dietary zinc repletion to zinc-deficient animals restored the zinc concentration in ectopic bone to a level comparable to that of zinc-sufficient animals. Thus, these experiments present strong evidence that zinc plays an active role in bone metabolism.

Accumulation of Labeled Zinc, Strontium, and Calcium in Bone Injuries

A significantly increased uptake of 65Zn administered intravenously was detected in healing bones of rats compared with control rats. The parameters used for measuring osteogenesis included: histologic examination, radiographic studies, and Ca 45 uptake in bone. The accumulation of 65Zn appeared to be correlated with bone formation. The data suggest a mobilization of zinc to the site of bone repair.

An effect of zinc deficiency on dental caries.

Abstract Rat pups suckled by dams fed a zinc-deficient diet developed higher levels of dental caries following a caries-test challenge than pups suckled by dams fed a zinc-adequate diet. The zinc deficient treatment was administered during the mineralization stage of tooth development before the molars erupted. The data shows that suboptimal zinc nutriture was associated with an increase in dental caries. Fluoride, a trace element, is recognized as a factor in preventing dental caries and its use has had a significant impact on dental health in this country. However, the possible roles of other trace elements have not been closely examined. Zinc is a trace element important to bone mineralization as well as in general nutrition. The effects on dental caries produced by the addition of zinc to rat diets have been reported (1, 2, 3). In those investigations, however, zinc supplements were added to diets that were adequate in zinc. Moreover, zinc supplements were fed after the teeth had appeared in the oral cavity. Because the critical period of tooth maturation occurs before eruption (4), post-eruptive zinc supplements probably should not markedly influence the development and, specifically, the mineralization of the tooth. Therefore, we investigated the influence of pre-eruptive zinc deficiency on caries development in rats.

Carcinoma of the lung presenting as a mandibular metastasis

Abstract A case of poorly differentiated large cell carcinoma arising in a bronchus was undetected until a metastasis to the left first molar region caused pain and difficulty in eating. Despite prompt referral for biopsy, the patient developed pneumonia and died before therapy could be instituted. The circumstances of the case illustrate the need for a high index of suspicion toward exuberant growths arising from recently traumatized oral tissue. They also support the notion that a significant mechanism for metastasis from the lung to the oral cavity may involve implantation of sputum-borne tumor cells into extraction sites and other traumatized areas containing fresh granulation tissue.

Removal of a bullet from the right infratemporal fossa: Report of a case

C onverse,l in 1945, stated that the treatment of gunshot wounds of the jaw may be divided into three distinct periods : Phase I (period of emergency care), Phase II (period of prercconstruction), and Phase III (period of final reconstruction). Phase I, the most critical for the patient, extends from the time of injury to 1 or 2 days after injury. Signs and symptoms of shock, asphyxia, severe blood loss, pain, and mental depression arc often observed. It is imperative that the patient’s physiologic needs be evaluated thoroughly and that emergency care be administered promptly. The wound is cleansed b;v the removal of small devitalized tags of tissue, loose detached bone fragments, and visible foreign bodies. Immobilization of the remaining fragments of bone by simple means is of great importance for the patient’s comfort. During Phase II, treatment consists of extraction of teeth in the line of fracture, removal of deeply located foreign bodies, securing of a definitive means of immobilizing fractured bones, and control of wound infection with antibiotics and irrigation. Phase III is the final reconstructive period. Heconstructive surgical procedures are simplified by the provision of adequate treatment during the earlier phases. The objectives of Phase III are to correct t.he deformity produced by loss of tissue and to establish adequate function of the jaws. Such reconstruction

The effects of multiple injections of thiopental sodium on the sleeping time and the physiologic disposition of the drug in male rats

Abstract On the basis of the data collected and statistically analyzed, it has been found that: 1. 1. Rats develop a tolerance to thiopental sodium which is maximum within three to five days after daily injections of the drug. 2. 2. Tolerance to thiopental sodium in rats is lost if the drug is discontinued for four days. 3. 3. Changes in body weight do not alter the course of tolerance to thiopental sodium in rats. 4. 4. There are significant differences between the tissue levels of thiopental sodium in tolerant and nontolerant rats sacrificed at various times(Times I and II).