Noboru Kosaka
University of Tokyo
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Featured researches published by Noboru Kosaka.
Cancer | 1999
Oichiro Kobori; Yujiro Kirihara; Noboru Kosaka; Toshihiko Hara
BACKGROUND Accurate preoperative staging is an important but difficult problem in determining therapy for patients with esophageal carcinoma. Positron emission tomography (PET) is used with [methyl-(11)C]choline ((11)C-choline) and 2-[(18)F]fluoro-2-deoxy-D-glucose ((18)F-FDG) to detect a variety of malignancies. The authors used PET with both of these agents to detect lymph node metastases in patients with esophageal carcinoma. METHODS Lymph node metastases in 33 patients with biopsy-proven esophageal carcinoma (16 patients with tumors classified as T1 and 17 patients with tumors classified as T2-4) was examined by PET using (11)C-choline and (18)F-FDG, and the accuracy of the results was correlated with pathology findings after surgery. RESULTS (11)C-choline PET was more effective than (18)F-FDG PET and computed tomography (CT) in detecting very small metastases localized in the mediastinum. It was ineffective, however, in detecting metastases localized in the upper abdomen, because of the normal uptake of (11)C-choline in the liver. (18)F-FDG PET was superior to CT in detecting metastases in the mediastinum and the upper abdomen, whereas (11)C-choline PET was superior to (18)F-FDG PET in detecting metastases in the mediastinum. When (11)C-choline PET and (18)F-FDG PET were used in combination, they were very effective in evaluating the lymph node status in both the mediastinum and the upper abdomen, and detected 85% of the metastatic lymph nodes (n = 46). CONCLUSIONS In this study, the combination of (11)C-choline PET and (18)F-FDG PET was very effective in evaluating the lymph node status of patients with esophageal carcinoma preoperatively.
European Journal of Nuclear Medicine and Molecular Imaging | 1996
Noboru Oriuchi; Tomio Inoue; Ikuko Hyashi; Sonoo Mizuiri; Noboru Kosaka; Nishikawa J; Yasuhito Sasaki; Keigo Endo
Gamma camera-based clearance techniques which use the renal uptake ratio (RUR) of the radiotracer are available to estimate the effective renal plasma flow (ERPF) and glomerular filtration rate. To evaluate the accuracy of these techniques, we measured RUR by an optimized procedure and compared it with standard ER-PF. Iodine-123 orthoiodohippurate (OIH) scintigraphy and simultaneouspara-aminohippurate clearance study for measuring standard ERPF were performed in three hospitals in 24 patients with normal or mildly impaired renal function. 1231-OIH was injected intravenously and 10-s consecutive imaging of the kidneys was started when the abdominal aorta was seen. The attenuation coefficient for 1231 was measured in each hospital using the same water-equivalent absorption materials and used for the attenuation correction. After subtracting background radioactivity, RURs were defined as the count ratios of fractional renal uptakes based on the integral from 1 to 2, 2 to 3, 1.5 to 2.5 and 1 to 3 min after the injection of 1231-OIH in relation to injected doses using the following three procedures in respect of attenuation correction: (1) RUR without attenuation correction, (2) RUR with fractional renal uptake corrected by the measured attenuation coefficient, (3) RUR with the total injected dose corrected by the absorption material. To decide upon the appropriate correction method and time interval, RURs were compared with standard ERPF. Among the three correction methods, procedure 2 showed the highest correlation between RUR and standard ERPF, but the correlation coefficient was low (r=0.75). No significant difference was observed among the RURs of each time interval. Individual kidney function measured from early renal uptake may be inaccurate even when appropriate correction is made for attenuation, background activity or time lag between injection and data acquisition. Gamma camera-based measurement of renal function using123I-OIH is limited with regard to accuracy and reproducibility, though it is convenient and non-invasive.
The Journal of Nuclear Medicine | 2002
Toshihiko Hara; Noboru Kosaka; Hiroichi Kishi
Chest | 2003
Toshihiko Hara; Noboru Kosaka; Tsuneo Suzuki; Koichiro Kudo; Hitoshi Niino
The Journal of Nuclear Medicine | 2000
Toshihiko Hara; Keizo Inagaki; Noboru Kosaka; Toyohiko Morita
The Journal of Nuclear Medicine | 1991
Tohru Ohtake; Noboru Kosaka; Toshiaki Watanabe; Ikuo Yokoyama; Toshiyuki Moritan; M. Masuo; M. Iizuka; K. Kozeni; Toshimitsu Momose; Shinya Oku
Journal of Neurosurgery | 2003
Toshihiko Hara; Tatsuya Kondo; Tetsuo Hara; Noboru Kosaka
Radioisotopes | 2006
Yoshikazu Mochiduki; Kimiichi Uno; Noboru Kosaka; Hiroko Watanabe; Masahiro Hoteida; Kazuya Sakaguchi; Yukio Okazaki; Yukiko Fukushima; Hiroshi Tsuboya; Mariko Ishii; Keiichirou Yamaguchi
Radioisotopes | 2000
Kazuo Kubota; Hiroshi Fukuda; Masatoshi Ito; Tomio Inoue; Keigo Endo; Takeo Isigaki; Hiroshi Nakamoto; Junji Konishi; Yasuo Kuwabara; Masayuki Sasaki; Joji Kawabe; Hironobu Ochi; Yoshiharu Yonekura; Yoshio Ishida; Kazuki Fukuchi; Akihiko Iida; Kotaro Higashi; Itaru Yamamoto; Mitsuru Ide; Seiei Yasuda; Mitsuaki Tatsumi; Tsunehiko Nishimura; Noboru Kosaka; Toshihiko Hara; Kengo Ito; Tatsuro Torizuka; Yasuomi Ouchi; Kanji Torizuka
Radioisotopes | 1985
Toru Matumoto; Takeshi Iinuma; Tatsuo Ishikawa; Yukio Tateno; Noboru Kosaka; Yoshitaka Okada; Kouzo Makita; Nishikawa J; Kikuo Machida; Masahiro Iio; Kazuhiko Seto; Koichi Uno; Guio Uchiyama; Yutaka Mori; Kenji Kawakami; Yaeko Takagi; Atushi Kubo; Yoshihisa Akiyama; Nobuharu Yui; Nakajima T; Hajime Murata; Kusakabe K; Hiyoshimaru Oyamada