Noboru Ōtake

The structure of neocarzinostatin chromophore possessing a novel bicyclo-[7,3,0]dodecadiyne system

Abstract The structure of the chromophore of an antitumor antibiotic neocarzinostatin has been elucidated as a bicycro[7,3,0]dodecadiyne system having naphthalenecarboxylic acid, aminosugar and ethylene carbonate units.

The structure of a new antibiotic, hygrolidin

Abstract The structure of a new antibiotic, hygrolidin has been determined as shown in fig. 3.

Structure of monazomycin, a new ionophohous antibiotic

Abstract The structure of monazomycin was determined by degradative study in combination with biosynthetic means using 13 C-NMR.

The structure of a new isotetracenone antibiotic, capoamycin

Abstract Based on 1 H and 13 C NMR spectral data and chemical degradation, the structure of capoamycin, a new isotetracenone antibiotic has been determined as shown in Fig. 1.

Studies on the ionophorous antibiotics. I. The crystal and molecular structure of salinomycin p-iodophenacyl ester

The crystal structure and absolute configuration of the p-iodophenacyl ester of salinomycin, Cs0H75012I, an antibiotic produced by Streptomyces albus, has been determined by three-dimensional X-ray analysis. The crystals are orthorhombic, space group P212t21 with four molecules in the unit cell of dimensions a= 20.981 (2), b= 22-761 (2), c= 10.493 (1)/~. The structure was solved by the heavy-atom method and refined by the block-diagonal least-squares method with anisotropic thermal factors for the non-hydrogen atoms. The final R is 0.066 for 3288 observed reflexions collected by diffractometry. The absolute configuration was determined by the use of the anomalous dispersion effect of the iodine atom for Cu K0c radiation. This work reveals that salinomycin is a new member of the polyether antibiotics containing a unique tricyclic spiroketal ring system and an unsaturated six-membered ring in the molecule.

The crystal and molecular structure of the silver salt of lysocellin a new polyether antibiotic

The molecular structure of the antibiotic lysocellin has been established from the crystal structure of the silver salt, C34H59O10Ag·½H2O.

The structures of new isotetracenone antibiotics, kerriamycins a, b and c

Based on 1H and 13C NMR spectral analysis, the structures of kerriamycins A, B and C, new isotetracenone antibiotics, have been elucidated as shown in Fig. 1. Kerriamycin A contains a novel sugar, kerriose.

The structure of adenomycin (C19-97 substance)

Abstract The structure of adenomycin, a new antibiotic active against Mycobacterium , has been established as a nucleoside consisting of adenine, D-ribose, (−)- chiro -inositol, L-gulosamine, L-serine and sulfate.

Synthesis of detoxininolactone derivatives and the revised absolute stereochemistry of detoxinine

Abstract A stereospecific synthesis of acetyl- L -valyl-detoxininolactone has been performed and the absolute stereochemistry of detoxinine has been revised to (2 S , 3 R , 1′ S )-2-(2′-carboxy-1′-hydroxyethyl)-3-hydroxypyrrolidine.

Studies on arugomycin, a new anthracycline antibiotic part II. structural elucidation of arugomycin

Abstract The total structure of arugomycin has been determined as shown in Fig. 1 based on spectroscopic data and chemical degradation.