Nobuhide Miyachi

A novel synthetic method of HMG-CoA reductase inhibitor NK-104 via a hydroboration-cross coupling sequence

Abstract The regioselective hydroboration of ethyl ( 3R, 5S )-3,5-isopropylidenedioxy-6-heptynoate, followed by the cross-coupling reaction with an aryl halide, provides ethyl ( 3R, 5S, 6E )-7-aryl-3,5-isopropylidenedioxy-6-heptenoate, a precursor of a highly potent HMG-CoA reductase inhibitor NK-104.

A synthesis of novel nine-membered dienones through a cyclic acetylenic oxy-cope rearrangement: The synthesis of dl-phoracantholide I

Abstract Phoracantholide I, having a ten-membered lactone, was synthesized through a new synthetic method which includes a cyclic acetylenic oxy-Cope rearrangement and ring-expansion by the Baeyer-Villiger oxidation of a nine-membered ketone.

A novel antileukemic sesquiterpene lactone: synthesis of racemic eriolanin

Abstract The synthesis of dl-eriolanin 1, highly oxygenated 1,10-seco-eudesmanolide isolated from the chloroform extracts of Eriophyllum lanatum Forbes (Compositae), is reported.

Perkin communications. The binary reagent PhSeSePH–CuOTf: a useful phenylselenylating agent

The binary reagent PhSeSePh–CuOTf has been found to be useful for the conversion of alkynyltrimethylsilanes into 1-phenylselenoalk-1-ynes as well as for phenylselenolactonization and phenylselenoetherification.