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Biochimica et Biophysica Acta | 1980

High molecular weight renin in stroke-prone spontaneously hypertensive rats

Kazuo Murakami; Fumiaki Suzuki; Nobuko Morita; Hiroyuki Ito; Kozo Okamoto; Shigehisa Hirose; Tadashi Inagami

Abstract The major form of renin in the plasma of the malignant phase of the strokeprone spontaneously hypertensive rat was a high molecular weight renin (M r = 56 000 ± 2000 , major isoelectric point ( p I) = 5.70 ± 0.08 ) instead of normal circulating renin of low molecular weight form. A high molecular weight renin (M r = 52 000 ± 3600 and p I = 5.60 ± 0.07 ) was also detected in kidney extracts of stroke-prone spontaneously hypertensive rats and control Wistar Kyoto strain of rats during all stages of their lives. However, there was no difference in the molecular weight and in the pI value of high molecular weight renin in the kidney extract between Wistar Kyoto rats and stroke-prone spontaneously hypertensive rats. Molecular properties of high molecular weight renin in the kidney extracts were very similar to those of high molecular weight renin in the plasma of the malignant phase of stroke-prone spontaneously hypertensive rats. Besides high molecular weight renin, a low molecular weight renin (M r = 35 600 ± 2900 and major p I value = 5.15 ± 0.05 ) was also observed in kidney extracts of Wistar Kyoto rats and stroke-prone spontaneously hypertensive rats during all stages of their lives, and its molecular properties were similar to those in their plasma. Therefore, a clear molecular shift of renin was observed in the plasma of the malignant phase of stroke-prone spontaneously hypertensive rats, but not in their kidney extracts.


Kidney & Blood Pressure Research | 1986

Renal High-Molecular-Weight Renin: Unusual Formation in the Aged Stroke-Prone Spontaneously Hypertensive Rats

Satoko Itoh; Motoharu Tanaka; Fumihiko Ikemoto; Kenjiro Yamamoto; Nobuko Morita; Kozo Okamoto

A high-molecular-weight renin (HMWR) was detected in the plasma (molecular weight 50,600) and renal cortical homogenate (molecular weight 57,000) of 25-week-old male stroke-prone spontaneously hypertensive rats (SHRSP), in contrast to the renin with a molecular weight of 38,000 in normotensive Wistar Kyoto rats (WKY) and 5-week-old SHRSP. However, renin granules contained only the renin with a molecular weight of 38,000, indicating that the renal HMWR is not a native form but is probably a renin/renin-binding protein complex. Such HMWR was not produced when the renal cortex was homogenized with an equal amount of renal cortex of WKY. Further, the HMWR of the aged SHRSP was converted into the 38,000-dalton renin, when incubated with the extract of renal cortex of WKY. Thus, the existence of a renal cortical substance that converts the renal HMWR into the 38,000-dalton renin was evidenced. This substance was fractionated with DEAE-cellulose and was characterized as a putative SH enzyme. We conclude that a deficiency in the HMWR-converting substance may be attributed to the unusual formation of HMWR in the aged SHRSP.


Experimental Animals | 1987

Maintenance of SHR Substrains and Development of a New Rat Strain

Tsuneyuki Suzuki; Nobuko Morita; Yoshio Ohta; Tomoteru Higashizawa

Comparative studies were performed on four SHR substrains; SHR C, SHR B2, SHRSP and M-SHRSP. When the blood pressure increased to 210 mmHg and above in SHRSP and MSHRSP, the plasma renin concentration, cerebrospinal fluid pressure and brain water content began to increase alongside of these elevations in blood pressure and showed significantly positive correlations. High molecular weight renin was also recognized after the blood pressure elevation above 210 mmHg. Blood pressures for SHR C and SHR B2 were below 210 mmHg.Continued successive selective brother-sister breeding of SHC and M-SHRSP hybrids produced a colony with severe hypertension (blood pressure above 210 mmHg) and marked hyper-cholesterolemia (plasma cholesterol level above 400 mg/dl) .


Japanese Heart Journal | 1977

Dietary Effects on Blood Pressure and Incidence of Stroke in SHRSP

Kozo Okamoto; Tsuneyuki Suzuki; Hiroyuki Ito; Nobuko Morita; Hideo Miyake; Kazuo Yamamoto; Tetsuo Murakami


Acta medica Kinki University | 1985

Establishment and characteristics of rat with precocious and severe hypertension (M-SHRSP)

Kozo Okamoto; Kazuo Yamamoto; Nobuko Morita; Yoshio Ohta


Japanese Heart Journal | 1977

Some Studies on Plasma Renin Activity in SHRSP

Nobuko Morita; Kozo Okamoto


Japanese Heart Journal | 1977

Dietary Effects on Blood Pressure and Incidence of Stroke in SHRSP:(1) Effects of Various Protein Sources

Kozo Okamoto; Tsuneyuki Suzuki; Hiroyuki Ito; Nobuko Morita; Hideo Miyake; Kazuo Yamamoto; Tetsuo Murakami


Japanese Heart Journal | 1976

Further Observations of Stroke-Prone SHR and Dietary Effects upon Incidence of Stroke

Kozo Okamoto; Tsuneyuki Suzuki; Hiroyuki Ito; Yasushi Mitachi; Nobuko Morita; Keiko Yada


Japanese Heart Journal | 1990

The Therapeutic Effect of Several Anti-hypertensive Drugs and Diet on M-SHRSP:Changes in Life Spans, Blood Pressures, Plasma Hormones, Fundus Oculi and Internal Organs. (Second report)

Yoshio Ohta; Hiroki Shiokawa; Takaaki Chikugo; Nobuko Morita; Yoh Hamada; Kozo Okamoto


Japanese Heart Journal | 1988

Hypertension-related hormones in M-SHRSP :The effects of anti-hypertension treatment

Nobuko Morita; Hiroki Shiokawa; Yoshio Ohta; Kozo Okamoto

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