Nobutake Tanaka
Nagoya University
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Publication
Featured researches published by Nobutake Tanaka.
Scientific Reports | 2018
Nobutake Tanaka; Suguru Yamada; Fuminori Sonohara; Masaya Suenaga; Masamichi Hayashi; Hideki Takami; Yukiko Niwa; Norifumi Hattori; Naoki Iwata; Mitsuro Kanda; Chie Tanaka; Daisuke Kobayashi; Goro Nakayama; Masahiko Koike; Michitaka Fujiwara; Tsutomu Fujii; Yasuhiro Kodera
Lysyl oxidase (LOX) family genes, particularly lysyl oxidase-like protein 2 (LOXL2), have been implicated in carcinogenesis, metastasis, and the epithelial-to-mesenchymal transition (EMT) in various cancers. This study aimed to explore the clinical implications of LOXL2 expression in pancreatic cancer (PC) in the context of EMT status. LOX family mRNA expression was measured in PC cell lines, and LOXL2 protein levels were examined in surgical specimens resected from 170 patients with PC. Higher LOXL2 expression was observed in cell lines from mesenchymal type PC than in those from epithelial type PC. A significant correlation between LOXL2 expression and the EMT status defined based on the expression of E-cadherin and vimentin was observed in surgical specimens (P < 0.01). The disease-free survival and overall survival rates among patients with low LOXL2 expression were significantly better than those among patients with high LOXL2 expression (P < 0.001). According to the multivariate analysis, high LOXL2 expression (P = 0.03) was a significant independent prognostic factor for patients with PC. Additionally, LOX inhibition significantly decreased PC cell proliferation, migration, and invasion in vitro. In conclusion, LOXL2 expression is potentially associated with PC progression, and LOXL2 expression represents a biomarker for predicting the prognosis of patients with PC who have undergone complete resection.
Annals of Gastroenterological Surgery | 2018
Fuminori Sonohara; Suguru Yamada; Nobutake Tanaka; Masaya Suenaga; Hideki Takami; Masamichi Hayashi; Yukiko Niwa; Hiroyuki Sugimoto; Norifumi Hattori; Mitsuro Kanda; Chie Tanaka; Daisuke Kobayashi; Goro Nakayama; Masahiko Koike; Michitaka Fujiwara; Yasuhiro Kodera
A reliable classification for predicting postoperative prognosis and perioperative risk of hepatocellular carcinoma (HCC) patients is required to make a precise decision for HCC treatment. In the present study, we assessed the perioperative and prognostic importance of indocyanine green (ICG) testing, tumor‐node‐metastasis (TNM) stage, albumin‐bilirubin (ALBI) grade, and ALBI‐TNM (ALBI‐T) score using consecutive resected HCC cases.
Gastric Cancer | 2015
Keisuke Kurimoto; Kiyoshi Ishigure; Yoshinari Mochizuki; Akiharu Ishiyama; Takanori Matsui; Seiji Ito; Hiroshi Nakayama; Nobutake Tanaka; Daisuke Kobayashi; Junichi Sakamoto; Akimasa Nakao; Yasuhiro Kodera
Journal of Clinical Oncology | 2014
Keisuke Kurimoto; Kiyoshi Ishigure; Yoshiyasu Kato; Yasuyuki Asai; Nobutake Tanaka; Song Ryo; Hidenobu Matsushita; Junichi Tobinaga; Ryuichi Fukuyama; Hiruhumi Kuroda; Tomoo Fujii
Hpb | 2018
Nobutake Tanaka; Suguru Yamada; Hideki Takami; Masaya Suenaga; Masamichi Hayashi; Yukiko Niwa; Yasuhiro Kodera
Hpb | 2018
Tsutomu Fujii; Suguru Yamada; Kenta Murotani; Hideki Takami; Nobutake Tanaka; Isaku Yoshioka; Kazuto Shibuya; T. Okumura; Yasuhiro Kodera
The Japanese Journal of Gastroenterological Surgery | 2017
Nobutake Tanaka; Tsutomu Fujii; Suguru Yamada; Hideki Takami; Masamichi Hayashi; Daishi Morimoto; Mitsuru Tashiro; Hiroyuki Sugimoto; Yasuhiro Kodera
The Japanese Journal of Gastroenterological Surgery | 2017
Daishi Morimoto; Tsutomu Fujii; Suguru Yamada; Kojiro Suzuki; Hideki Takami; Mitsuru Tashiro; Nobutake Tanaka; Masamichi Hayashi; Hiroyuki Sugimoto; Yasuhiro Kodera
The Japanese Journal of Gastroenterological Surgery | 2017
Mitsuru Tashiro; Tsutomu Fujii; Suguru Yamada; Kojiro Suzuki; Daishi Morimoto; Nobutake Tanaka; Hideki Takami; Masamichi Hayashi; Hiroyuki Sugimoto; Yasuhiro Kodera
Pancreatology | 2017
Nobutake Tanaka; Tsutomu Fujii; Suguru Yamada; Daishi Morimoto; Hideki Takami; Masamichi Hayashi; Hiroyuki Sugimoto; Yasuhiro Kodera
