Nobuyoshi Hirose

Commonly affected body sites in 92 Japanese combat sports participants with Trichophyton tonsurans infection

Outbreaks of Trichophyton tonsurans infection constitute one of the serious problems among combat sports practitioners in Japan. To facilitate the diagnosis of individuals at risk, we undertook a study to determine which body sites are most commonly infected. We reviewed medical data, hairbrush culture results and questionnaire information from patients with T. tonsurans infection who were admitted to the dermatology clinic of Juntendo University hospital from 2000 to 2004. The study included 92 patients (87 males), aged 6–38 years (mean age: 18.4 years old). Eighty‐nine patients were judo practitioners and three were wrestlers. Twenty‐eight patients (30.4%) were asymptomatic carriers. In 64 patients, 51 patients (55.4%) with tinea corporis, 27 patients (29.3%) with tinea capitis, and/or one patient (1.1%) with tinea manuum were seen. Tinea corporis was observed on the forehead, auricles, nape of the neck, bilateral shoulders, left side of the upper chest, both elbows, back of the left hand to the wrist and both knees. Tinea capitis was most common in the occipitonuchal region at the hairline and in the temporal and frontal regions, at both auricles. Initial screening of these sites might facilitate the identification of the infection especially in judo practitioners.

Management and follow-up survey of Trichophyton tonsurans infection in a university judo club

The prevalence of Trichophyton tonsurans infection of the scalp in members of a university judo club (combat sport) was investigated over a 3.5‐year period using a questionnaire survey and an assay based on fungal culture by the hairbrush method. In November 2002, 11 (35%) of 31 athletes were found to be positive for T. tonsurans infection by the hairbrush method and provided treatment with oral and topical antifungal agents according to a prescribed protocol. All the infected subjects became culture‐negative following this treatment. We continued to conduct screening examinations every year in the month of April, when new university enrolment occurs. During three‐and‐a‐half years of follow‐up, there have been no outbreaks of the infection among the members of the university judo club. There were some positive culture results among the newly enrolled students, but these cases also became culture‐negative with treatment. No re‐infection has been noted after graduation among the club members who had been educated about and treated for the infection. Our findings indicate that the spread of T. tonsurans infection in sports clubs can be controlled by regular mass screening examination, therapy and measures at regular intervals to prevent the infection.

Screening examination and treatment of Trichophyton tonsurans infection in judo athletes affiliated with the University Judo Federation of Tokyo

In Japan, Trichophyton tonsurans infection has become an increasing problem among combat sports participants. We investigated the prevalence of T. tonsurans infection in athletes affiliated to judo clubs in the 21 First Division universities that were registered with the University Judo Federation of Tokyo in 2008. Study procedures performed by the subjects included (i) completion of a questionnaire concerning lifestyle, risk factors for tinea corporis and medical history; (ii) scrubbing the scalp with a circular hairbrush to obtain samples for fungal culture; (iii) anti‐fungal treatment as recommended by a dermatologist, based on the number of fungal colonies isolated from the hairbrush; and (iv) repeat testing using the hairbrush method 3 months after treatment recommendations were received. Of 902 study subjects, 102 (11.3%) yielded positive hairbrush culture results. Of these, 14 individuals (13.7%) had tinea corporis; the remainder were asymptomatic. Conversion to negative fungal culture was observed in 85 of 96 culture‐positive individuals who performed the second hairbrush culture test following treatment. Control of T. tonsurans infection among judo athletes could be achieved by educating athletes, trainers and coaches in judo clubs concerning detection, prevention, and treatment of T. tonsurans infection.

The transformation of technical-tactical behaviors for hand techniques used in attacking below the belt after the 2010 International Judo Federation rule revision

Background Due to a 2010 rule revision, attack with the arms or hands below the belt is prohibited, with the penalty being hansoku-make for the first offense. This strict rule must have affected competitors’ technical-tactical behaviors with regards to using hands and arms below the belt in contests. The purpose of the present study is transformation of technical-tactical behaviors for hand techniques attacking below the belt in men’s contests before and after the 2010 rule revision. Material & Methods: 436 men’s contests from the 2009 Grand Slam Tokyo and the 2010 Grand Slam Paris were examined. DVDs of the Federation of All Japan Judo were used. Five hand techniques used in below the belt maneuvers as referenced in the Kodokan manual were investigated. The analysts unanimously decided if the techniques performed by competitors could be categorized within one of the five hand techniques studied. Results: Use of kibisu-gaeshi significantly decreased (p<0.05). Use of sukui-nage used in countering an opponent’s crossguard grab significantly increased (p<0.05). Use of kata-guruma not utilizing below the belt hand or arm grabbing significantly increased (p<0.01). German, English, and Japanese contestants significantly decreased in their use of hand techniques below the belt (p<0.01, p <0.05, p<0.05, respectively). Conclusions: Sukui-nage was increasingly used to counter the opponent’s use of the cross-guard grab; the kata-guruma technique underwent a style transformation. On the other hand, kibisu-gaeshi could not be used effectively with the rule revision.

Epistasis, physical capacity-related genes and exceptional longevity: FNDC5 gene interactions with candidate genes FOXOA3 and APOE

BackgroundForkhead box O3A (FOXOA3) and apolipoprotein E (APOE) are arguably the strongest gene candidates to influence human exceptional longevity (EL, i.e., being a centenarian), but inconsistency exists among cohorts. Epistasis, defined as the effect of one locus being dependent on the presence of ‘modifier genes’, may contribute to explain the missing heritability of complex phenotypes such as EL. We assessed the potential association of epistasis among candidate polymorphisms related to physical capacity, as well as antioxidant defense and cardiometabolic traits, and EL in the Japanese population. A total of 1565 individuals were studied, subdivided into 822 middle-aged controls and 743 centenarians.ResultsWe found a FOXOA3 rs2802292 T-allele-dependent association of fibronectin type III domain-containing 5 (FDNC5) rs16835198 with EL: the frequency of carriers of the FOXOA3 rs2802292 T-allele among individuals with the rs16835198 GG genotype was significantly higher in cases than in controls (P < 0.05). On the other hand, among non-carriers of the APOE ‘risk’ ε4-allele, the frequency of the FDNC5 rs16835198 G-allele was higher in cases than in controls (48.4% vs. 43.6%, P < 0.05). Among carriers of the ‘non-risk’ APOE ε2-allele, the frequency of the rs16835198 G-allele was higher in cases than in controls (49% vs. 37.3%, P < 0.05).ConclusionsThe association of FDNC5 rs16835198 with EL seems to depend on the presence of the FOXOA3 rs2802292 T-allele and we report a novel association between FNDC5 rs16835198 stratified by the presence of the APOE ε2/ε4-allele and EL. More research on ‘gene*gene’ and ‘gene*environment’ effects is needed in the field of EL.