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Dive into the research topics where Nobuyuki Hashimoto is active.

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Featured researches published by Nobuyuki Hashimoto.


Mayo Clinic Proceedings | 2004

Left Ventricular Rupture Associated With Takotsubo Cardiomyopathy

Yoshihiro J. Akashi; Tamotsu Tejima; Harumizu Sakurada; Hisao Matsuda; Kengo Suzuki; Kensuke Kawasaki; Katsuhiko Tsuchiya; Nobuyuki Hashimoto; Haruki Musha; Masayoshi Sakakibara; Kiyoshi Nakazawa; Fumihiko Miyake

A 70-year-old woman was admitted to the hospital with chest discomfort after quarreling with her neighbors. Electrocardiography revealed ST-segment elevation in leads I, II, III, aVL, aVF, and V2 through V6. Coronary angiography demonstrated normal arteries, but left ventriculography showed apical akinesis and basal hyperkinesis. Takotsubo cardiomyopathy was diagnosed on the basis of these characteristic findings. The creatine kinase and creatine kinase-MB concentrations were elevated at admission and reached maximum levels 6 hours after admission. The plasma level of brain natriuretic peptide was 10.7 pg/mL (reference range, <18.4 pg/mL) on the first hospital day. ST-segment elevation in leads I, II, III, aVL, aVF, and V2 through V6 persisted at 72 hours after admission. On the third hospital day, sudden rupture of the left ventricle occurred, and despite extensive resuscitation efforts, the patient died. Takotsubo cardiomyopathy presents in a manner similar to that of acute myocardial infarction, but ventricular systolic function usually returns to normal within a few weeks. To our knowledge, this is the first reported case of fatal left ventricular rupture associated with takotsubo cardiomyopathy. We suggest that takotsubo cardiomyopathy may be a newly recognized cause of sudden cardiac death.


European Journal of Heart Failure | 2005

Reversible ventricular dysfunction takotsubo cardiomyopathy

Yoshihiro J. Akashi; Haruki Musha; Keisuke Kida; Kae Itoh; Koji Inoue; Kensuke Kawasaki; Nobuyuki Hashimoto; Fumihiko Miyake

Recently, many cardiologists have recognized the existence of a rapidly reversible form of heart failure of unknown origin characterized by a takotsubo‐shaped, dyskinetic left ventricle on left ventriculography.


International Journal of Nephrology and Renovascular Disease | 2015

Elevation of urinary liver-type fatty acid binding protein after cardiac catheterization related to cardiovascular events

Atsuko Kamijo-Ikemori; Nobuyuki Hashimoto; Takeshi Sugaya; Mikako Hisamichi; Yugo Shibagaki; Fumihiko Miyake; Kenjiro Kimura

Purpose Contrast medium (CM) induces tubular hypoxia via endothelial damage due to direct cytotoxicity or viscosity. Urinary liver-type fatty acid binding protein (L-FABP) increases along with tubular hypoxia and may be a detector of systemic circulation injury. The aim of this study was to evaluate the clinical usefulness of detecting increases in urinary L-FABP levels due to administration of CM, as a prognostic biomarker for cardiovascular disease in patients without occurrence of CM-induced nephropathy undergoing cardiac catheterization procedure (CCP). Methods Retrospective longitudinal analyses of the relationship between urinary L-FABP levels and occurrence of cardiovascular events were performed (n=29). Urinary L-FABP was measured by ELISA before CCP, and at 6, 12, 24, and 48 hours after CCP. Results Urinary L-FABP levels were significantly higher at 12 hours (P<0.05) and 24 hours (P<0.005) after CCP compared with before CCP, only in the patients with occurrence of cardiovascular events (n=17), but not in those without cardiovascular events (n=12). The parameter with the largest area under the curve (0.816) for predicting the occurrence of cardiovascular events was the change in urinary L-FABP at 24 hours after CCP. The difference in urinary L-FABP levels (ΔL-FABP ≥11.0 μg/g creatinine) between before CCP and at 24 hours after CCP was a risk factor for the occurrence of cardiovascular events (hazard ratio, 4.93; 95% confidence interval, 1.27–19.13; P=0.021). Conclusion Measurement of urinary L-FABP before CCP and at 24 hours after CCP in patients with mild to moderate renal dysfunction may be an important indicator for risk stratification of onset of cardiovascular events.


Journal of Echocardiography | 2010

Acute myocardial infarction in a young adult patient with simultaneous total occlusion of double coronary arteries

Motoki Miyauchi; Masaki Izumo; Yoshihiro J. Akashi; Kengo Suzuki; Shonosuke Ryu; Nobuyuki Hashimoto; Fumihiko Miyake; Sachihiko Nobuoka; Eiji Ohtaki

We report an otherwise healthy 16-year-old male patient with simultaneous double vessel acute myocardial infarction. Coronary angiography (CAG) showed simultaneous total occlusion of the left anterior descending artery (LAD) and the left circumflex artery (LCX). Emergent percutaneous coronary intervention (PCI) was performed on the diseased lesions. After PCI, coronary artery aneurysms were found in both the LAD and LCX. The patient was discharged after a 56-day hospitalization. The New York Heart Association (NYHA) Functional Classification at discharge was II. Medical therapy became ineffective over time because of exacerbated ischemic mitral regurgitation; successful mitral annuloplasty was performed. The post-operative course was uneventful.


Internal Medicine | 2006

Gender Difference in the Level of Highdensity Lipoprotein Cholesterol in Elderly Japanese Patients with Coronary Artery Disease

Haruki Musha; Akio Hayashi; Keisuke Kida; Eiji Takahashi; Kae Suzuki; Kensuke Kawasaki; Koji Inoue; Yoshihiro J. Akashi; Katsuhiko Tsuchiya; Masahiro Yamauchi; Tomoyuki Kunishima; Nobuyuki Hashimoto


Japanese Heart Journal | 1999

Dynamic changes of QT dispersion as a predictor of myocardial ischemia on exercise testing in patients with angina pectoris.

Haruki Musha; Takehiko So; Nobuyuki Hashimoto; Eto F; Atsushi Ozawa; Tomoyuki Kunishima; Masahiro Murayama


Japanese Heart Journal | 2002

Relationship between infarction location and size to QT dispersion in patients with chronic myocardial infarction.

Nobuyuki Hashimoto; Haruki Musha; Atsushi Ozawa; Yukiko Imai; Kensuke Kawasaki; Osamu Miyazu; Junzo Nagashima; Takehiko So; Fumihiko Miyake; Masahiro Murayama


Circulation | 2004

Congenital Absence of the Left Circumflex Coronary Artery Associated With Acute Myocardial Infarction

Nobuyuki Hashimoto; Junzo Nagashima; Osamu Miyazu; Yoshihiro J. Akashi; Kensuke Kawasaki; Yukiko Imai; Katsuhiko Tsuchiya; Atsushi Ozawa; Takehiko So; Haruki Musha; Masayosi Sakakibara; Fumihiko Miyake


Journal of Cardiology | 2005

Long-term follow-up of a patient with Kawasaki disease and coronary aneurysm associated with asymptomatic thrombosis: a case report.

Hisao Matsuda; Nobuyuki Hashimoto; Kengo Suzuki; Hidefumi Aoyagi; Yoshihiro J. Akashi; Kensuke Kawasaki; Katsuhiko Tsuchiya; Atsushi Ozawa; Junzo Nagashima; Haruki Musha


Japanese Circulation Journal-english Edition | 2008

PJ-535 The Effectiveness of Urinary Liver-type Fatty Acid-biding Protein in Patients with Renal Artery Stenosis(Kidney/Renal circulation(07)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Hideki Ouchi; Nobuyuki Hashimoto; Eiji Takahashi; Kihei Yoneyama; Taishi Mikami; Yoshihiro J. Akashi; Ken Kongoji; Koji Inoue; Masahiro Yamauchi; Fumihiko Miyake

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Haruki Musha

St. Marianna University School of Medicine

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Fumihiko Miyake

St. Marianna University School of Medicine

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Kensuke Kawasaki

St. Marianna University School of Medicine

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Katsuhiko Tsuchiya

St. Marianna University School of Medicine

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Yoshihiro J. Akashi

St. Marianna University School of Medicine

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Masahiro Yamauchi

St. Marianna University School of Medicine

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Kengo Suzuki

St. Marianna University School of Medicine

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Yukiko Imai

St. Marianna University School of Medicine

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Koji Inoue

St. Marianna University School of Medicine

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