Nobuyuki Shiraishi
Astellas Pharma
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Publication
Featured researches published by Nobuyuki Shiraishi.
Bioorganic & Medicinal Chemistry Letters | 2009
Tadaatsu Hanadate; Masaki Tomishima; Nobuyuki Shiraishi; Daisuke Tanabe; Hiroshi Morikawa; David Barrett; Satoru Matsumoto; Kazumi Ohtomo; Katsuyuki Maki
Sordarin is a unique natural product antifungal agent that is an inhibitor of elongation factor 2. To improve biological activity, we synthesized various compounds by novel modification of the aglycone, sordaricin. As a result, we have discovered the novel sordarin derivative FR290581. This compound exhibited superior activity and a good pharmacokinetic profile, and also displayed good in vivo activity against Candida albicans.
Archive | 2005
Satoshi Hayashibe; Takatoshi Kanayama; Junya Ohmori; Takahiko Tobe; Kyoichi Maeno; Yoshitsugu Shitaka; Jotarou Suzuki; Shigeki Kawabata; Nobuyuki Shiraishi; Shingo Yamasaki; Daisuke Suzuki; Hiroaki Hoshii
Archive | 1999
Hidenori Ohki; Kenji Murano; Takashi Tojo; Nobuyuki Shiraishi; Takahiro Matsuya; Hiroshi Matsuda; Hiroaki Mizuno; David Barrett; Keiji Matsuda; Kohji Kawabata
Archive | 2007
Satoshi Hayashibe; Shingo Yamasaki; Kazushi Watanabe; Nobuyuki Shiraishi; Daisuke Suzuki; Hiroaki Hoshii; Junya Ohmori; Takatoshi Kanayama
Archive | 2008
Satoshi Hayashibe; Shingo Yamasaki; Nobuyuki Shiraishi; Hiroaki Hoshii; Takahiko Tobe
Archive | 2008
Isao Kinoyama; Satoshi Miyamoto; Takehiro Miyazaki; Yohei Koganemaru; Yuichiro Kawamoto; Nobuyuki Shiraishi; Hiroaki Hoshii; Akio Kuroda; Mayako Yamazaki; Minoru Yasuda; Hiroaki Mizuno
Archive | 2017
Ayako Moritomo; Hiroyuki Moritomo; Minoru Sakurai; Nobuyuki Shiraishi; Noriyuki Kawano; Ryuichi Sekioka; Shimpei Kawakami; Takayuki Suzuki; Wataru Hamaguchi
Archive | 2015
Nobuyuki Shiraishi; Hiroaki Hoshii; Wataru Hamaguchi; Eriko Honjo; Tomofumi Takuwa; Yuji Kondo; Takayuki Goto
Archive | 2014
白石 宜之; Nobuyuki Shiraishi; 博昭 星井; Hiroaki Hoshii; Wataru Hamaguchi; 絵理子 本庄; Eriko Honjo; 知文 宅和; Tomofumi Takuwa; 雄二 近藤; Yuji Kondo; 貴行 後藤; Takayuki Goto
Archive | 2009
Seiji Yoshimura; Noriyuki Kawano; Tomoaki Kawano; Daisuke Sasuga; Takanori Koike; Hideyuki Watanabe; Hiroki Fukudome; Nobuyuki Shiraishi; Ryosuke Munakata; Hiroaki Hoshii; Kayoko Mihara
