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Dive into the research topics where Noriko Maeda is active.

Publication


Featured researches published by Noriko Maeda.


Bioorganic & Medicinal Chemistry Letters | 2001

New 5-HT1A receptor agonists possessing 1,4-Benzoxazepine scaffold exhibit highly potent anti-ischemic effects

Katsuhide Kamei; Noriko Maeda; Ryoko Ogino; Makoto Koyama; Mika Nakajima; Toshio Tatsuoka; Tomochika Ohno; Teruyoshi Inoue

A series of new 3-substituted-4-(4-aminobutyl)-1,4-benzoxazepin-5(4H)-one derivatives (1-5) which showed a very high affinity for 5-HT1A receptor with good selectivity over dopamine D2 receptor was synthesized. Among these compounds, 3-chloro-4-[4-[4-(2-pyridinyl)-1,2,3,6-tetrahydropyridin-1-yl]butyl]-1,4-benzoxazepin-5(4H)-one (5: SUN N4057) exhibited remarkable neuroprotective activity in a transient middle cerebral artery occlusion (t-MCAO) model.


Bioorganic & Medicinal Chemistry | 2006

Synthesis, SAR studies, and evaluation of 1,4-benzoxazepine derivatives as selective 5-HT1A receptor agonists with neuroprotective effect: Discovery of Piclozotan.

Katsuhide Kamei; Noriko Maeda; Kayoko Nomura; Makoto Shibata; Ryoko Katsuragi-Ogino; Makoto Koyama; Mika Nakajima; Teruyoshi Inoue; Tomochika Ohno; Toshio Tatsuoka


Bioorganic & Medicinal Chemistry Letters | 2005

New piperidinyl- and 1,2,3,6-tetrahydropyridinyl-pyrimidine derivatives as selective 5-HT1A receptor agonists with highly potent anti-ischemic effects

Katsuhide Kamei; Noriko Maeda; Ryoko Katsuragi-Ogino; Makoto Koyama; Mika Nakajima; Toshio Tatsuoka; Tomochika Ohno; Teruyoshi Inoue


Tetrahedron Letters | 2005

A practical synthetic method for vinyl chlorides and vinyl bromides from ketones via the corresponding vinyl phosphate intermediates

Katsuhide Kamei; Noriko Maeda; Toshio Tatsuoka


Archive | 1996

Benzoxazepine derivatives, salts thereof, and drugs containing the same

Toshio Tatsuoka; Katsuhide Kamei; Noriko Maeda; Teruyoshi Inoue; Mika Nishimura; Ichiro Hirotsu


Archive | 1998

Process of production of 4-substituted-3-halogeno-1,4-benzoxazepine derivative and salts thereof

Katsuhide Kamei; Noriko Maeda; Toshio Tatsuoka


Archive | 1999

Benzoxazepine derivatives and their salts and medicaments containing the same

Toshio Tatsuoka; Katsuhide Kamei; Noriko Maeda; Teruyoshi Inoue; Mika Nakajima; Ichiro Hirotsu


Archive | 1998

Verfahren zur herstellung von 4-substituierten 3-halogeno-1,4-benzoxazepinderivaten und deren salzen Process for the preparation of 4-substituted-3-halogeno-1,4-benzoxazepinderivaten and salts thereof

Katsuhide Kamei; Noriko Maeda; Toshio Tatsuoka


Archive | 1998

A process for the preparation of 4-substituted-3-halogeno-1,4-benzoxazepinderivaten and salts thereof

Katsuhide Kamei; Noriko Maeda; Toshio Tatsuoka


Archive | 1996

Benzoxalepin derivatives, their salts and medicines containing them

Toshio Tatsuoka; Katsuhide Kamei; Noriko Maeda; Teruyoshi Inoue; Mika Nishimura; Ichiro Hirotsu

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Tomochika Ohno

Kyoto Pharmaceutical University

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