Noritaka Kuroda
Takeda Pharmaceutical Company
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Noritaka Kuroda.
Bioorganic & Medicinal Chemistry | 2010
Toshitake Kobayashi; Satoshi Sasaki; Naoki Tomita; Seiji Fukui; Noritaka Kuroda; Masaharu Nakayama; Atsushi Kiba; Yoshihiro Takatsu; Tetsuya Ohtaki; Fumio Itoh; Atsuo Baba
GPR54 is a G protein-coupled receptor (GPCR) which was formerly an orphan receptor. Recent functional study of GPR54 revealed that the receptor has an essential role to modulate sex-hormones including GnRH. Though antagonists of GPR54 are expected to be novel drugs for sex-hormone dependent diseases such as prostate cancer or endometriosis, small molecule GPR54 antagonists have not been reported. We have synthesized a series of 2-acylamino-4,6-diphenylpyridines to identify potent GPR54 antagonists. Detailed structure-activity relationship studies led to compound 9l with an IC(50) value of 3.7nM in a GPR54 binding assay, and apparent antagonistic activity in a cellular functional assay.
Bioorganic & Medicinal Chemistry | 2003
Tomoyasu Ishikawa; Nobuyuki Matsunaga; Hiroyuki Tawada; Noritaka Kuroda; Yutaka Nakayama; Yukio Ishibashi; Mitsumi Tomimoto; Yukihiro Ikeda; Yoshihiko Tagawa; Yuji Iizawa; Kenji Okonogi; Shohei Hashiguchi; Akio Miyake
ACS Combinatorial Science | 2006
Noritaka Kuroda; and Nick Hird; David G. Cork
Archive | 1994
Tatsuhiko Kaneko; Kenichi Kashiwa; Noritaka Kuroda; 謙一 柏; 龍彦 金兒; 典孝 黒田
Archive | 1994
Noritaka Kuroda; Tatsuhiko Kaneko; Kenichi Kashiwa
Chemical & Pharmaceutical Bulletin | 2001
Noritaka Kuroda; Taeko Hattori; Chieko Kitada; Tohru Sugawara
Chemical & Pharmaceutical Bulletin | 2001
Noritaka Kuroda; Taeko Hattori; Yoko Fujioka; David G. Cork; Chieko Kitada; Tohru Sugawara
Archive | 2001
Shohei Hashiguchi; Tomohiro Kaku; Noritaka Kuroda; Masami Kusaka; Yoshi Nara; Akihiro Tasaka; Masuo Yamaoka
Archive | 2001
Shohei Hashiguchi; Toshihiro Kako; Noritaka Kuroda; Masami Kusaka; Tei Nara; Akihiro Tasaka; Masuo Yamaoka; 智弘 加来; 禎 奈良; 万寿夫 山岡; 雅美 日下; 昌平 橋口; 昭弘 田坂; 典孝 黒田
Archive | 2001
Noritaka Kuroda; Yoshi Nara; Shohei Hashiguchi; Akihiro Tasaka; Masami Kusaka; Masuo Yamaoka; Tomohiro Kaku
