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Dive into the research topics where Noriyoshi Yamamoto is active.

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Featured researches published by Noriyoshi Yamamoto.


Bioorganic & Medicinal Chemistry Letters | 2010

Synthesis and pharmacological evaluation of 1,1,3-substituted urea derivatives as potent TNF-α production inhibitors

Hiroshi Enomoto; Ayako Sawa; Hiroshi Suhara; Noriyoshi Yamamoto; Hiroyuki Inoue; Chikako Setoguchi; Fumio Tsuji; Masahiro Okamoto; Yoshimasa Sasabuchi; Masato Horiuchi; Masakazu Ban

A three substituted urea derivative, SA13353 (compound 1a), exhibited potent inhibitory activity against lipopolysaccharide (LPS)-induced TNF-alpha production. We focused on the 1,1-substituted moiety (R(1) and R(2)) of SA13353 and investigated substituent effects of this moiety on LPS-induced TNF-alpha production by oral administration in rats. The synthesis of the urea derivatives was performed rapidly in a one-pot manner using a manual synthesizer. Several compounds containing hydrophobic substituents at this moiety showed more potent inhibitory activities than SA13353.


Archive | 2001

Tnf-.alpha. production inhibitors

Masakazu Ban; Hiroshi Suhara; Masato Horiuchi; Noriyoshi Yamamoto; Hiroshi Enomoto; Hiroyuki Inoue


Archive | 1995

1,3-dialkylurea derivative

Yoichi Kawashima; Kenichi Fujimura; Hiroshi Suhara; Noriyoshi Yamamoto; Hiromi Matsumoto; Nobuaki Miyawaki; Yuko Fujita


Archive | 1995

Novel 1,3-dialkylurea derivatives

Yoichi Kawashima; Kenichi Fujimura; Hiroshi Suhara; Noriyoshi Yamamoto; Hiromi Matsumoto; Nobuaki Miyawaki; Yuko Fujita


Archive | 2012

3-hydroxy-6h-benzo[c]chromen-6-one derivative and method for producing same

Kazuhiro Kudou; Noriyoshi Yamamoto; Masakazu Ban; Atsushi Ohno


Archive | 2014

3-HYDROXY-6H-BENZO [C] CHROMENE-6-ONE DERIVATIVE AND MANUFACTURING METHOD THEREOF

Kazuhiro Kudou; Noriyoshi Yamamoto; Masakazu Ban; Atsushi Ohno


Archive | 2013

Industrial process for preparation of 1,2-dihydroquinoline derivative or a salt thereof, and intermediate for preparation thereof

Noriyoshi Yamamoto; Atsushi Ohno; Kazuhiro Kudou; Masakazu Ban; Takashi Mimura; Takashi Ohtani


Archive | 2006

TNF-α production inhibitors

Masakazu Ban; Hiroshi Suhara; Masato Horiuchi; Noriyoshi Yamamoto; Hiroshi Enomoto; Hiroyuki Inoue


Archive | 2012

3−ヒドロキシ−6H−ベンゾ[c]クロメン−6−オン誘導体およびその製造方法

Kazuhiro Kudou; 一弘 工藤; Noriyoshi Yamamoto; 悟功 山本; Masakazu Ban; 正和 伴; Atsushi Ohno; 敦嗣 大野


Archive | 2006

TNF-a production inhibitors

Masakazu Ban; Hiroshi Suhara; Masato Horiuchi; Noriyoshi Yamamoto; Hiroshi Enomoto; Hiroyuki Inoue

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Hiroshi Suhara

SANTEN PHARMACEUTICAL CO.

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Masakazu Ban

SANTEN PHARMACEUTICAL CO.

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Hiroshi Enomoto

SANTEN PHARMACEUTICAL CO.

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Hiroyuki Inoue

SANTEN PHARMACEUTICAL CO.

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Masato Horiuchi

SANTEN PHARMACEUTICAL CO.

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Atsushi Ohno

SANTEN PHARMACEUTICAL CO.

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Kazuhiro Kudou

SANTEN PHARMACEUTICAL CO.

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